Quality of life in patients with atrial fibrillation: How to assess it and how to improve it

Europace

Volumn 16, Issue 6, 2014, Pages 787-796

  Aliot, Etienne ^a   Botto, Giovanni L ^b   Crijns, Harry J ^c   Kirchhof, Paulus ^d,e  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

^b SANT ANNA HOSPITAL   (Italy)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Atrial fibrillation (AF); Cardiac rhythm disorder; Management strategies; Quality of life (QoL); Rate control; Rhythm control

Indexed keywords

ABLATION THERAPY; ARRHYTHMIA SYMPTOM CHECKLIST FREQUENCY AND SEVERITY SCALE; ATRIAL FIBRILLATION EFFECT ON QUALITY OF LIFE QUESTIONNAIRE; CANADIAN CARDIOVASCULAR SOCIETY SEVERITY IN ATRIAL FIBRILLATION SCALE; CARDIOVERSION; CLINICAL ASSESSMENT; CLINICAL ASSESSMENT TOOL; EURO QUALITY OF LIFE 5 DIMENSIONAL QUESTIONNAIRE; HEART ATRIUM FIBRILLATION; HEART PACING; HEART RATE; HEART RHYTHM; HUMAN; INTERMETHOD COMPARISON; MEDICAL OUTCOME STUDY SHORT FORM HEALTH SURVEY; MINI MENTAL STATE EXAMINATION; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; PACEMAKER; PHARMACEUTICAL CARE; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUALITY OF LIFE; QUALITY OF LIFE IN ATRIAL FIBRILLATION QUESTIONNAIRE; QUALITY OF LIFE OF ATRIAL FIBRILLATION QUESTIONNAIRE; RECURRENT DISEASE; REVIEW; SHORT FORM 12; SHORT FORM 36; SPECIFIC ACTIVITY SCALE; UNIVERSITY OF TORONTO ATRIAL FIBRILLATION SEVERITY SCALE; ATRIAL FIBRILLATION; HEALTH CARE QUALITY; OUTCOME ASSESSMENT; PROCEDURES; PSYCHOLOGY; QUESTIONNAIRE; SEVERITY OF ILLNESS INDEX; STANDARDS; TOTAL QUALITY MANAGEMENT; TREATMENT OUTCOME;

ATRIAL FIBRILLATION; HUMANS; OUTCOME ASSESSMENT (HEALTH CARE); QUALITY ASSURANCE, HEALTH CARE; QUALITY IMPROVEMENT; QUALITY OF LIFE; QUESTIONNAIRES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84901835434     PISSN: 10995129     EISSN: 15322092     Source Type: Journal    
DOI: 10.1093/europace/eut369     Document Type: Review

References (103)

1. Bialy D, Lehmann MH, Schumacher DN, Steinman RT, Meissner MD. Hospitalization for arrhythmias in the United States: importance of atrial fibrillation. J Am Coll Cardiol 1992;19:41A.
2. Santini M, De Ferrari GM, Pandozi C, Alboni P, Capucci A, Disertori M et al. Atrial fibrillation requiring urgent medical care. Approach and outcome in the various departments of admission. Data from the atrial Fibrillation/flutter Italian REgistry (FIRE). Ital Heart J 2004;5:205-13.
3. Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Europace 2010;12: 1360-420.
4. Testa MA, Simonson DC. Assessment of quality-of-life outcomes. N Engl J Med 1996;334:835-40.
5. Bubien RS, Knotts-Dolson SM, Plumb VJ, Kay GN. Effect of radiofrequency catheter ablation on health-related quality of life and activities of daily living in patients with recurrent arrhythmias. Circulation 1996;94:1585-91.
6. Reynolds MR, Ellis E, Zimetbaum P. Quality of life in atrial fibrillation: measurement tools and impact of interventions. J Cardiovasc Electrophysiol 2008;19:762-8.
7. Luderitz B, Jung W. Quality of life in patients with atrial fibrillation. Arch Intern Med 2000;160:1749-57.
8. Badia X, Arribas F, Ormaetxe JM, Peinado R, de LosTerreros MS. Development of a questionnaire to measure health-related quality of life (HRQoL) in patients with atrial fibrillation (AF-QoL). Health Qual Life Outcomes 2007;5:37.
9. Thrall G, Lane D, Carroll D, Lip GY. Quality of life in patients with atrial fibrillation: a systematic review. Am J Med 2006;119:448 e1-19.
10. McCabe PJ. Psychological distress in patients diagnosed with atrial fibrillation: the state of the science. J Cardiovasc Nurs 2009;25:40-51.
11. Savelieva I, Paquette M, Dorian P, Luderitz B, Camm AJ. Quality of life in patients with silent atrial fibrillation. Heart 2001;85:216-7.
12. Defaye P, Dournaux F, Mouton E. Prevalence of supraventricular arrhythmias from the automated analysis of data stored in the DDD pacemakers of 617 patients: the AIDA study. The AIDA Multicenter Study Group. Automatic interpretation for diagnosis assistance. Pacing Clin Electrophysiol 1998;21:250-5.
13. Grönefeld GC, Hohnloser SH. Quality of life in atrial fibrillation: an increasingly important issue. Eur Heart J Suppl 2003;5:H25-33.
14. Wann LS, Curtis AB, January CT, Ellenbogen KA, Lowe JE, Estes NA III et al. 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (updating the 2006 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2011;123:104-23.
15. Kirchhof P, Auricchio A, Bax J, Crijns H, Camm J, Diener HC et al. Outcome parameters for trials in atrial fibrillation: recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork and the European Heart Rhythm Association. Europace 2007;9:1006-23.
16. Brooks R. EuroQol: the current state of play. Health Policy 1996;37:53-72.
17. Goldman L, Hashimoto B, Cook EF, Loscalzo A. Comparative reproducibility and validity of systems for assessing cardiovascular functional class: advantages of a new specific activity scale. Circulation 1981;64:1227-34.
18. Devins GM. Illness intrusiveness and the psychosocial impact of lifestyle disruptions in chronic life-threatening disease. Adv Ren Replace Ther 1994;1:251-63.
19. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992;30:473-83.
20. Ware J Jr, Kosinski M, Keller SD. A 12-item short-formhealth survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996;34:220-33.
21. Schag CC, Heinrich RL, Ganz PA. Karnofsky performance status revisited: reliability, validity, and guidelines. J Clin Oncol 1984;2:187-93.
22. Grieco A, Long CJ. Investigation of the Karnofsky performance status as a measure of quality of life. Health Psychol 1984;3:129-42.
23. Kirchhof P, Fetsch T, Hanrath P, Meinertz T, Steinbeck G, Lehmacher W et al. Targeted pharmacological reversal of electrical remodeling after cardioversion-rationale and design of the Flecainide Short-Long (Flec-SL) trial. Am Heart J 2005; 150:899.
24. Reynolds MR, Lavelle T, Essebag V, Cohen DJ, Zimetbaum P. Influence of age, sex, and atrial fibrillation recurrence on quality of life outcomes in a population of patients with new-onset atrial fibrillation: the Fibrillation Registry Assessing Costs, Therapies, Adverse events and Lifestyle (FRACTAL) study. Am Heart J 2006;152:1097-103.
25. Berkowitsch A, Neumann T, Kurzidim K, Reiner C, Kuniss M, Siemon G et al. Comparison of generic health survey SF-36 and arrhythmia related symptomseverity check list in relation to post-therapy AF recurrence. Europace 2003;5:351-5.
26. Spertus J, Dorian P, Bubien R, Lewis S, Godejohn D, Reynolds MR et al. Development and validation of the Atrial Fibrillation Effect on QualiTy-of-Life (AFEQT) Questionnaire in patients with atrial fibrillation. Circ Arrhythm Electrophysiol 2011; 4:15-25.
27. Rienstra M, Lubitz SA, Mahida S. Symptoms and functional status of patients with atrial fibrillation: state-of-the-art and future research opportunities. Circulation 2012;125:2933-43.
28. Arribas F, Ormaetxe JM, Peinado R, Perulero N, Ramirez P, Badia X. Validation of the AF-QoL, a disease-specific quality of life questionnaire for patients with atrial fibrillation. Europace 2010;12:364-70.
29. Braganca EO, Filho BL, Maria VH, Levy D, de Paola AA. Validating a new quality of life questionnaire for atrial fibrillation patients. Int J Cardiol 2009;143:391-8.
30. Yamashita T, Komatsu T, Kumagai K, Uno K, Niwano S, Fijiki A. Internal consistency and reproducibility of Atrial fibrillation Quality of Life Questionnaire (AFQLQ). Jpn J Electrocardiol 2005;25:488-94.
31. Yamashita T, Kumagai K, Koretsune Y, Mitamura H, Okamura K, Ogawa S. A new method for evaluating quality of life specific to patients with atrial fibrillation: Atrial Fibrillation Quality of Life Questionnaire (AFQLQ). Jpn J Electrocardiol 2003;23:332-43.
32. Dorian P, Paquette M, Newman D, Green M, Connolly SJ, Talajic M et al. Quality of life improves with treatment in the Canadian Trial of atrial fibrillation. Am Heart J 2002;143:984-90.
33. Dorian P, Jung W, Newman D, Paquette M, Wood K, Ayers GM et al. The impairment of health-related quality of life in patients with intermittent atrial fibrillation: implications for the assessment of investigational therapy. J Am Coll Cardiol 2000;36: 1303-9.
34. Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Europace 2010;12:1360-420.
35. Dorian P, Cvitkovic SS, Kerr CR, Crystal E, Gillis AM, Guerra PG et al. A novel, simple scale for assessing the symptom severity of atrial fibrillation at the bedside: the CCS-SAF scale. Can J Cardiol 2006;22:383-6.
36. Dorian P, Guerra PG, Kerr CR, O'Donnell SS, Crystal E, Gillis AM et al. Validation of a new simple scale to measure symptoms in atrial fibrillation: the Canadian Cardiovascular Society Severity in Atrial Fibrillation scale. Circ Arrhythm Electrophysiol 2009; 2:218-24.
37. Goldman L, Hashimoto B, Cook EF, Loscaizo A. Comparative reproducibility and validity of systems for assessing cardiovascular functional class: advantages of a new specific activity scale. Circulation 1981;64:1227-34.
38. Erdogan A, Carlsson J, Neumann T, Berkowitsch A, Neuzner J, Hamm CW et al. Quality-of-life in patients with paroxysmal atrial fibrillation after catheter ablation: results of long-term follow-up. Pacing Clin Electrophysiol 2003;26:678-84.
39. Lonnerholm S, Blomstrom P, Nilsson L, Oxelbark S, Jideus L, Blomstrom-Lundqvist C. Effects of the maze operation on health-related quality of life in patients with atrial fibrillation. Circulation 2000;101:2607-11.
40. Kang Y, Bahler R. Health related quality of life in patients newly diagnosed with atrial fibrillation. Eur J Cardiovasc Nurs 2003;3:71-6.
41. Carlsson J, Miketic S, Windeler J, Cuneo A, Haun S, Micus S et al. Randomized trial of rate-control versus rhythm-control in persistent atrial fibrillation: the Strategies of Treatment of Atrial Fibrillation (STAF) study. J Am Coll Cardiol 2003;41:1690-6.
42. Gronefeld GC, Lilienthal J, Kuck KH, Hohnloser SH. Impact of rate versus rhythm control on quality of life in patients with persistent atrial fibrillation. Results from a prospective randomized study. Eur Heart J 2003;24:1430-6.
43. Hagens VE, Ranchor AV, Van Sonderen E, Bosker HA, Kamp O, Tijssen JG et al. Effect of rate or rhythm control on quality of life in persistent atrial fibrillation. Results from the Rate Control Versus Electrical Cardioversion (RACE) Study. J Am Coll Cardiol 2004;43:241-7.
44. Paquette M, Roy D, Talajic M, Newman D, Couturier A, Yang C et al. Role of gender and personality on quality-of-life impairment in intermittent atrial fibrillation. Am J Cardiol 2000;86:764-8.
45. Howes CJ, Reid MC, Brandt C, Ruo B, Yerkey MW, Prasad B et al. Exercise tolerance and quality of life in elderly patients with chronic atrial fibrillation. J Cardiovasc Pharmacol Ther 2001;6:23-9.
46. van den Berg MP, Hassink RJ, Tuinenburg AE, van Sonderen EF, Lefrandt JD, de Kam PJ et al. Quality of life in patients with paroxysmal atrial fibrillation and its predictors: importance of the autonomic nervous system. Eur Heart J 2001;22:247-53.
47. Kay GN, Ellenbogen KA, Giudici M, Redfield MM, Jenkins LS, Mianulli M et al. The Ablate and Pace Trial: a prospective study of catheter ablation of the A Vconduction system and permanent pacemaker implantation for treatment of atrial fibrillation. APT Investigators. J Interv Card Electrophysiol 1998;2:121-35.
48. Marshall HJ, Harris ZI, Griffith MJ, Gammage MD. Atrioventricular nodal ablation and implantation of mode switching dual chamber pacemakers: effective treatment for drug refractory paroxysmal atrial fibrillation. Heart 1998;79:543-7.
49. Levy T, Walker S, Rex S, Paul V. Ablate and pace for drug refractory paroxysmal atrial fibrillation. Is ablation necessary? Int J Cardiol 2000;75:187-95.
50. Takahashi Y, Yoshito I, Takahashi A, Harada T, Mitsuhashi T, Shirota K et al. AVnodal ablation and pacemaker implantation improves hemodynamic function in atrial fibrillation. Pacing Clin Electrophysiol 2003;26:1212-7.
51. Lee SH, Chen SA, Tai CT, Chiang CE, Wen ZC, Cheng JJ et al. Comparisons of quality of life and cardiac performance after complete atrioventricular junction ablation and atrioventricular junction modification in patients with medically refractory atrial fibrillation. J Am Coll Cardiol 1998;31:637-44.
52. Twidale N, McDonald T, Nave K, Seal A. Comparison of the effects of AV nodal ablation versus AVnodal modification in patients with congestive heart failure and uncontrolled atrial fibrillation. Pacing Clin Electrophysiol 1998;21:641-51.
53. Natale A, Zimerman L, Tomassoni G, Newby K, Leonelli F, Fanelli R et al. AV node ablation and pacemaker implantation after withdrawal of effective rate-control medications for chronic atrial fibrillation: effect on quality of life and exercise performance. Pacing Clin Electrophysiol 1999;22:1634-9.
54. Levy T, Walker S, Mason M, Spurrell P, Rex S, Brant S et al. Importance of rate control or rate regulation for improving exercise capacity and quality of life in patients with permanent atrial fibrillation and normal left ventricular function: a randomised controlled study. Heart 2001;85:171-8.
55. Brignole M, Menozzi C, Gasparini M, Bongiorni MG, Botto GL, Ometto R et al. An evaluation of the strategy of maintenance of sinus rhythm by antiarrhythmic drug therapy after ablation and pacing therapy in patients with paroxysmal atrial fibrillation. Eur Heart J 2002;23:892-900.
56. Duff HJ, Raj SR, Exner DV, Sheldon RS, Roach D, Mitchell LB et al. Randomized controlled trial of fixed rate versus rate responsive pacing after radiofrequency atrioventricular junction ablation: quality of life, ventricular refractoriness, and paced QT dispersion. J Cardiovasc Electrophysiol 2003;14:1163-70.
57. Weerasooriya R, Davis M, Powell A, Szili-Torok T, Shah C, Whalley D et al. The Australian Intervention Randomized Control of Rate in Atrial Fibrillation Trial (AIRCRAFT). J Am Coll Cardiol 2003;41:1697-702.
58. Tse HF, Newman D, Ellenbogen KA, Buhr T, Markowitz T, Lau CP. Effects of ventricular rate regularization pacing on quality of life and symptoms in patients with atrial fibrillation (Atrial fibrillation symptoms mediated by pacing to mean rates [AF SYMPTOMS study]). Am J Cardiol 2004;94:938-41.
59. Fiala M, Wichterle D, Bulková V, Sknouril L, Nevralová R, Toman O et al. A prospective evaluation of haemodynamics, functional status, and quality of life after radiofrequency catheter ablation of long-standing persistent atrial fibrillation. Europace 2014;16:15-25.
60. Newman DM, Dorian P, Paquette M, Sulke N, Gold MR, Schwartzman DS et al. Effect of an implantable cardioverter defibrillator with atrial detection and shock therapies on patient-perceived, health-related quality of life. Am Heart J 2003;145:841-6.
61. Berry C, Stewart S, Payne EM, McArthur JD, McMurray JJ. Electrical cardioversion for atrial fibrillation: outcomes in 'real-life' clinical practice. Int J Cardiol 2001;81:29-35.
62. Kale M, Bennett DH. Atrial septal pacing in the prevention of paroxysmal atrial fibrillation refractory to antiarrhythmic drugs. Int J Cardiol 2002;82:167-75.
63. Jessurun ER, van Hemel NM, Defauw JA, Stofmeel MA, Kelder JC, de la Riviere AB et al. Results of maze surgery for lone paroxysmal atrial fibrillation. Circulation 2000; 101:1559-67.
64. Jessurun ER, van Hemel NM, Defauw JJ, Brutel De La Riviere A, Stofmeel MA, Kelder JC et al. A randomized study of combining maze surgery for atrial fibrillation with mitral valve surgery. J Cardiovasc Surg (Torino) 2003;44:9-18.
65. Alli O, Doshi S, Kar S, Reddy V, Sievert H, Mullin C et al. Quality of life assessment in the randomized PROTECT AF (Percutaneous Closure of the Left Atrial Appendage Versus Warfarin Therapy for Prevention of Stroke in Patients With Atrial Fibrillation) trial of patients at risk for strokewith nonvalvular atrial fibrillation. J Am Coll Cardiol 2013;61:1790-8.
66. Tse HF, Lam YM, Lau CP, Cheung BM, Kumana CR. Comparison of digoxin versus low-dose amiodarone for ventricular rate control in patients with chronic atrial fibrillation. Clin Exp Pharmacol Physiol 2001;28:446-50.
67. Pepine CJ. Effects of pharmacologic therapy on health-related quality of life in elderly patients with atrial fibrillation: a systematic review of randomized and nonrandomized trials. Clin Med Insights Cardiol 2013;7:1-20. Epub 22 January 2013.
68. Chen MS, Marrouche NF, Khaykin Y, Gillinov AM, Wazni O, Martin DO et al. Pulmonary vein isolation for the treatment of atrial fibrillation in patients with impaired systolic function. J Am Coll Cardiol 2004;43:1004-9.
69. Purerfellner H, Martinek M, Aichinger J, Nesser HJ, Kempen K, Janssen JP. Quality of life restored to normal in patients with atrial fibrillation after pulmonary vein ostial isolation. Am Heart J 2004;148:318-25.
70. Guedon-Moreau L, Capucci A, Denjoy I, Morgan CC, Perier A, Leplege A et al. Impact of the control of symptomatic paroxysmal atrial fibrillation on health-related quality of life. Europace 2010;12:634-42.
71. Crijns HJ. Rate versus rhythm control in patients with atrial fibrillation: what the trials really say. Drugs 2005;65:1651-67.
72. Aves T, Dorian P. Paroxysmal atrial fibrillation and health-related quality of life: the importance of keeping score. Europace 2010;12:606-7.
73. Jenkins LS, Brodsky M, Schron E, Chung M, Rocco T Jr, Lader E et al. Quality of life in atrial fibrillation: the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Am Heart J 2005;149:112-20.
74. Suman-Horduna I, Roy D, Frasure-Smith N, Talajic M, Lespérance F, Blondeau L et al. Quality of life and functional capacity in patients with atrial fibrillation and congestive heart failure. J Am Coll Cardiol 2013;61:455-60.
75. Savelieva I, Camm AJ. Clinical relevance of silent atrial fibrillation: prevalence, prognosis, quality of life, and management. J Interv Card Electrophysiol 2000;4:369-82.
76. Peinado R, Arribas F, Ormaetxe JM, Badia X. Variation in quality of life with type of atrial fibrillation. Rev Esp Cardiol 2010;63:1402-9.
77. Thrall G, Lip GY, Carroll D, Lane D. Depression, anxiety, and quality of life in patients with atrial fibrillation. Chest 2007;132:1259-64.
78. Singh SN, Tang XC, Singh BN, Dorian P, Reda DJ, Harris CL et al. Quality of life and exercise performance in patients in sinus rhythmversus persistent atrial fibrillation: a Veterans Affairs Cooperative Studies Program Substudy. J Am Coll Cardiol 2006;48: 721-30.
79. Zimetbaum P. Amiodarone for atrial fibrillation. N Engl J Med 2007;356:935-41.
80. Mead GE, Keir S. Association between cognitive impairment and atrial fibrillation: a systematic review. J Stroke Cerebrovasc Dis 2001;10:35-43.
81. Wozakowska-Kaplon B, Opolski G, Kosior D, Jaskulska-Niedziela E, Maroszynska-Dmoch E, Wlosowicz M. Cognitive disorders in elderly patients with permanent atrial fibrillation. Kardiol Pol 2009;67:487-93.
82. Alboni P, Botto GL, Baldi N, Luzi M, Russo V, Gianfranchi L et al. Outpatient treatment of recent-onset atrial fibrillation with the 'pill-in-the-pocket' approach. N Engl J Med 2004;351:2384-91.
83. Furberg CD, Psaty BM, Manolio TA, Gardin JM, Smith VE, Rautaharju PM. Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study). Am J Cardiol 1994;74:236-41.
84. Blackshear JL, Kopecky SL, Litin SC, Safford RE, Hammill SC. Management of atrial fibrillation in adults: prevention of thromboembolism and symptomatic treatment. Mayo Clin Proc 1996;71:150-60.
85. Page RL, Wilkinson WE, Clair WK, McCarthy EA, Pritchett EL. Asymptomatic arrhythmias in patients with symptomatic paroxysmal atrial fibrillation and paroxysmal supraventricular tachycardia. Circulation 1994;89:224-7.
86. Kirchhof P, Bax J, Blomstrom-Lundquist C, Calkins H, Camm AJ, Cappato R et al. Early and comprehensive management of atrial fibrillation: proceedings from the 2nd AFNET/EHRA consensus conference on atrial fibrillation entitled 'research perspectives in atrial fibrillation'. Europace 2009;11:860-85.
87. Schotten U, Verheule S, Kirchhof P, Goette A. Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. Physiol Rev 2010;91:265-325.
88. Kirchhof P. Can we improve outcomes in AF patients by early therapy? BMC Med 2009;7:72.
89. Roy D, Pratt CM, Torp-Pedersen C, Wyse DG, Toft E, Juul-Moller S et al. Vernakalant hydrochloride for rapid conversion of atrial fibrillation: a phase 3, randomized, placebo-controlled trial. Circulation 2008;117:1518-25.
90. Fuster V, Ryden LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 guidelines for the management of patients with atrial fibrillation) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace 2006;8:651-745.
91. Calkins H, Reynolds MR, Spector P, Sondhi M, Xu Y, Martin A et al. Treatment of atrial fibrillation with antiarrhythmic drugs or radiofrequency ablation: two systematic literature reviews and meta-analyses. Circ Arrhythm Electrophysiol 2009;2: 349-61.
92. Cosio FG, Aliot E, Botto GL, Heidbuchel H, Geller CJ, Kirchhof P et al. Delayed rhythmcontrol of atrial fibrillation may be a cause of failure to prevent recurrences: reasons for change to active antiarrhythmic treatment at the time of the first detected episode. Europace 2008;10:21-7.
93. Stewart S, Hart CL, Hole DJ, McMurray JJ. A population-based study of the longterm risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley study. Am J Med 2002;113:359-64.
94. Benjamin EJ, Wolf PA, D'Agostino RB, Silbershatz H, Kannel WB, Levy D. Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation 1998; 98:946-52.
95. Kirchhof P, Auricchio A, Bax J, Crijns H, Camm J, Diener HC et al. Outcome parameters for trials in atrial fibrillation: recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork and the European Heart Rhythm Association. Europace 2007;9:1006-23.
96. Kerr CR, Boone J, Connolly SJ, Dorian P, Green M, Klein G et al. The Canadian Registry of Atrial Fibrillation: a noninterventional follow-up of patients after the first diagnosis of atrial fibrillation. Am J Cardiol 1998;82:82N-5N.
97. Jahangir A, Lee V, Friedman PA, Trusty JM, Hodge DO, Kopecky SL et al. Long-term progression and outcomes with aging in patients with lone atrial fibrillation: a 30-year follow-up study. Circulation 2007;115:3050-6.
98. Nattel S, Burstein B, Dobrev D. Atrial remodeling and atrial fibrillation: mechanisms and implications. Circ Arrhythm Electrophysiol 2008;1:62-73.
99. http://clinicaltrials.gov/ct2/show/NCT00911508 Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation Trial (CABANA) (24 July 2013, date last accessed).
100. http://clinicaltrials.gov/show/NCT01288352 Early Treatment of Atrial Fibrillation for Stroke Prevention Trial (EAST) (date last accessed July 24, 2013).
101. http://clinicaltrials.gov/ct2/show/NCT00911508 Routine Versus Aggressive Upstream Rhythm Control for Prevention of Early Atrial Fibrillation in Heart Failure (RACE 3) (24 July 2013, date last accessed).
102. Fumagalli S, Boncinelli L, Bondi E, Caleri V, Gatto S, Di Bari M et al. Does advanced age affect the immediate and long-term results of direct-current external cardioversion of atrial fibrillation? J Am Geriatr Soc 2002;50:1192-7.
103. Zado E, Callans DJ, Riley M, Hutchinson M, Garcia F, Bala R et al. Long-term clinical efficacy and risk of catheter ablation for atrial fibrillation in the elderly. J Cardiovasc Electrophysiol 2008;19:621-6.