KLRG1 activity is regulated by association with the transferrin receptor

European Journal of Immunology

Volumn 44, Issue 6, 2014, Pages 1851-1856

  Schweier, Oliver ^a   Hofmann, Maike ^a   Pircher, Hanspeter ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Heteromeric protein; Inhibitory receptor; Killer cell lectin like receptor

Indexed keywords

DISULFIDE; INTERLEUKIN 2; KILLER CELL LECTIN LIKE RECEPTOR G1; NATURAL KILLER CELL LECTIN LIKE RECEPTOR; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE SILENCING; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

HETEROMERIC PROTEIN; INHIBITORY RECEPTOR; KILLER CELL LECTIN-LIKE RECEPTOR;

ANIMALS; CELL LINE; CELL PROLIFERATION; GENE EXPRESSION REGULATION; KILLER CELLS, NATURAL; LECTINS, C-TYPE; MICE; RECEPTORS, TRANSFERRIN; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 84901833914     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201344234     Document Type: Article

References (21)

1. Blaser, C., Kaufmann, M. and Pircher, H., Virus-activated CD8 T cells and lymphokine-activated NK cells express the mast cell function-associated antigen, an inhibitory C-type lectin. J. Immunol. 1998. 161: 6451-6454.
2. Hanke, T., Corral, L., Vance, R. E. and Raulet, D. H., 2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells. Eur. J. Immunol. 1998. 28: 4409-4417.
3. Voehringer, D., Koschella, M. and Pircher, H., Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). Blood 2002. 100: 3698-3702.
4. Grundemann, C., Bauer, M., Schweier, O., von Oppen, N., Lassing, U., Saudan, P., Becker, K. F. et al., Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1. J. Immunol. 2006. 176: 1311-1315.
5. Ito, M., Maruyama, T., Saito, N., Koganei, S., Yamamoto, K. and Matsumoto, N., Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. J. Exp. Med. 2006. 203: 289-295.
6. Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L. et al., Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 2007. 27: 281-295.
7. Voehringer, D., Blaser, C., Brawand, P., Raulet, D. H., Hanke, T. and Pircher, H., Viral infections induce abundant numbers of senescent CD8 T cells. J. Immunol. 2001. 167: 4838-4843.
8. Robbins, S. H., Nguyen, K. B., Takahashi, N., Mikayama, T., Biron, C. A. and Brossay, L., Cutting edge: inhibitory functions of the killer cell lectin-like receptor G1 molecule during the activation of mouse NK cells. J. Immunol. 2002. 168: 2585-2589.
9. Grundemann, C., Schwartzkopff, S., Koschella, M., Schweier, O., Peters, C., Voehringer, D. and Pircher, H., The NK receptor KLRG1 is dispensable for virus-induced NK and CD8+ T-cell differentiation and function in vivo. Eur. J. Immunol. 2010. 40: 1303-1314.
10. Corral, L., Takizawa, H., Hanke, T., Jamieson, A. M. and Raulet, D. H., A new monoclonal antibody reactive with several Ly49 NK cell receptors mediates redirected lysis of target cells. Hybridoma 1999. 18: 359-366.
11. Guthmann, M. D., Tal, M. and Pecht, I., A secretion inhibitory signal transduction molecule on mast cells is another C-type lectin. Proc. Natl. Acad. Sci. USA 1995. 92: 9397-9401.
12. Hofmann, M., Schweier, O. and Pircher, H., Different inhibitory capacities of human and mouse KLRG1 are linked to distinct disulfide-mediated oligomerizations. Eur. J. Immunol. 2012. 42: 2484-2490.
13. Rosshart, S., Hofmann, M., Schweier, O., Pfaff, A. K., Yoshimoto, K., Takeuchi, T., Molnar, E. et al., Interaction of KLRG1 with E-cadherin: new functional and structural insights. Eur. J. Immunol. 2008. 38: 3354-3364.
14. Jing, S. Q. and Trowbridge, I. S., Identification of the intermolecular disulfide bonds of the human transferrin receptor and its lipid-attachment site. Embo. J. 1987. 6: 327-331.
15. Alvarez, E., Girones, N. and Davis, R. J., Intermolecular disulfide bonds are not required for the expression of the dimeric state and functional activity of the transferrin receptor. Embo. J. 1989. 8: 2231-2240.
16. Lesley, J. F. and Schulte, R. J., Inhibition of cell growth by monoclonal anti-transferrin receptor antibodies. Mol. Cell. Biol. 1985. 5: 1814-1821.
17. Weissman, A. M., Klausner, R. D., Rao, K. and Harford, J. B., Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor. J. Cell. Biol. 1986. 102: 951-958.
18. Li, Y., Hofmann, M., Wang, Q., Teng, L., Chlewicki, L. K., Pircher, H. and Mariuzza, R. A., Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition. Immunity 2009. 31: 35-46.
19. Larrick, J. W. and Cresswell, P., Transferrin receptors on human B and T lymphoblastoid cell lines. Biochim. Biophys. Acta. 1979. 583: 483-490.
20. Fuchs, H., Lucken, U., Tauber, R., Engel, A. and Gessner, R., Structural model of phospholipid-reconstituted human transferrin receptor derived by electron microscopy. Structure 1998. 6: 1235-1243.
21. Andersen, P. S., Geisler, C., Buus, S., Mariuzza, R. A. and Karjalainen, K., Role of the T cell receptor ligand affinity in T cell activation by bacterial superantigens. J. Biol. Chem. 2001. 276: 33452-33457.