Preclinical toxicity screening of intrathecal oxytocin in rats and dogs

Anesthesiology

Volumn 120, Issue 4, 2014, Pages 951-961

  Yaksh, Tony L ^a   Hobo, Shotaro ^b   Peters, Christopher ^b   Osborn, Kent G ^c   Richter, Philip J ^d   Rossi, Steven S ^c   Grafe, Marjorie R ^e   Eisenach, James C ^b  

^a University of California at San Diego   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYTOCIN; OXYTOCIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR ASSESSMENT; BIOCHEMISTRY; BLOOD PRESSURE; DOG; DRUG BLOOD LEVEL; DRUG SCREENING; HEART RATE; HISTOPATHOLOGY; MALE; MOTOR ACTIVITY; NONHUMAN; PHYSIOLOGIC MONITORING; PRIORITY JOURNAL; PRURITUS; RAT; SCRATCHING; SPINAL CORD; ANIMAL; ANIMAL BEHAVIOR; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; FEMALE; FOLLOW UP; INTRASPINAL DRUG ADMINISTRATION; RANDOMIZATION; SPRAGUE DAWLEY RAT; TOXICITY TESTING;

ANIMALS; BEHAVIOR, ANIMAL; BLOOD PRESSURE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; FEMALE; FOLLOW-UP STUDIES; HEART RATE; INJECTIONS, SPINAL; MALE; OXYTOCICS; OXYTOCIN; PRURITUS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TOXICITY TESTS, ACUTE; TOXICITY TESTS, CHRONIC;

EID: 84901800581     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000148     Document Type: Article

References (39)

1. Lee HJ, Macbeth AH, Pagani JH, Young WS III: Oxytocin: The great facilitator of life. Prog Neurobiol 2009; 88:127-51.
2. Kang YS, Park JH: Brain uptake and the analgesic effect of oxytocin-Its usefulness as an analgesic agent. Arch Pharm Res 2000; 23:391-5.
3. Eisenach JC, Pan P, Smiley RM, Lavand'homme P, Landau R, Houle TT: Resolution of pain after childbirth. Anesthesiology 2013; 118:143-51.
4. Gutierrez S, Liu B, Hayashida K, Houle TT, Eisenach JC: Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: Role of spinal oxytocin. Anesthesiology 2013; 118:152-9.
5. Saper CB, Loewy AD, Swanson LW, Cowan WM: Direct hypothalamo- Autonomic connections. Brain Res 1976; 117:305-12.
6. Condés-Lara M, Martínez-Lorenzana G, Rojas-Piloni G, Rodríguez-Jiménez J: Branched oxytocinergic innervations from the paraventricular hypothalamic nuclei to superficial layers in the spinal cord. Brain Res 2007; 1160:20-9.
7. Takeda S, Kuwabara Y, Mizuno M: Effects of pregnancy and labor on oxytocin levels in human plasma and cerebrospinal fluid. Endocrinol Jpn 1985; 32:875-80.
8. Condés-Lara M, Maie IA, Dickenson AH: Oxytocin actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal rats. Brain Res 2005; 1045:124-33.
9. Martínez-Lorenzana G, Espinosa-López L, Carranza M, Aramburo C, Paz-Tres C, Rojas-Piloni G, Condés-Lara M: PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats. Pain 2008; 140:265-73.
10. Miranda-Cardenas Y, Rojas-Piloni G, Martínez-Lorenzana G, Rodríguez-Jiménez J, López-Hidalgo M, Freund-Mercier MJ, Condés-Lara M: Oxytocin and electrical stimulation of the paraventricular hypothalamic nucleus produce antinociceptive effects that are reversed by an oxytocin antagonist. Pain 2006; 122:182-9.
11. De LaTorre S, Rojas-Piloni G, Martínez-Lorenzana G, Rodríguez-Jiménez J, Villanueva L, Condés-Lara M: Paraventricular oxytocinergic hypothalamic prevention or interruption of long-term potentiation in dorsal horn nociceptive neurons: Electrophysiological and behavioral evidence. Pain 2009; 144:320-8.
12. Breton JD, Veinante P, Uhl-Bronner S, Vergnano AM, Freund- Mercier MJ, Schlichter R, Poisbeau P: Oxytocin- induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition. Mol Pain 2008; 4:19.
13. Breton JD, Poisbeau P, Darbon P: Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord. Mol Pain 2009; 5:63.
14. Charbit B, Funck-Brentano C, Samain E, Jannier-Guillou V, Albaladejo P, Marty J: QT interval prolongation after oxytocin bolus during surgical induced abortion. Clin Pharmacol Ther 2004; 76:359-64.
15. Rosseland LA, Hauge TH, Grindheim G, Stubhaug A, Langesater E: Changes in blood pressure and cardiac output during cesarean delivery: The effects of oxytocin and carbetocin compared with placebo. Anesthesiology 2013; 119:541-51.
16. Caudle RM, Isaac L: Intrathecal dynorphin(1-13) results in an irreversible loss of the tail-flick reflex in rats. Brain Res 1987; 435:1-6.
17. Gaumann DM, Yaksh TL: Intrathecal somatostatin in rats: Antinociception only in the presence of toxic effects. Anesthesiology 1988; 68:733-42.
18. Yaksh TL, Tozier N, Horais KA, Malkmus S, Rathbun M, Lafranco L, Eisenach J: Toxicology profile of N- methyl-d-aspartate antagonists delivered by intrathecal infusion in the canine model. Anesthesiology 2008; 108:938-49.
19. Manning M, Misicka A, Olma A, Bankowski K, Stoev S, Chini B, Durroux T, Mouillac B, Corbani M, Guillon G: Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics. J Neuroendocrinol 2012; 24:609-28.
20. Yaksh TL, Collins JG: Studies in animals should precede human use of spinally administered drugs. Anesthesiology 1989; 70:4-6.
21. Yaksh TL, Noueihed RY, Durant PA: Studies of the pharmacology and pathology of intrathecally administered 4- Anilinopiperidine analogues and morphine in the rat and cat. Anesthesiology 1986; 64:54-66.
22. Sabbe MB, Grafe MR, Pfeifer BL, Mirzai TH, Yaksh TL: Toxicology of baclofen continuously infused into the spinal intrathecal space of the dog. Neurotoxicology 1993; 14:397-410.
23. Sabbe MB, Grafe MR, Mjanger E, Tiseo PJ, Hill HF, Yaksh TL: Spinal delivery of sufentanil, alfentanil, and morphine in dogs. Physiologic and toxicologic investigations. Anesthesiology 1994; 81:899-920.
24. Yaksh TL, Rathbun M, Jage J, Mirzai T, Grafe M, Hiles RA: Pharmacology and toxicology of chronically infused epidural clonidine.HCl in dogs. Fundam Appl Toxicol 1994; 23:319-35.
25. Xu JJ, Walla BC, Diaz MF, Fuller GN, Gutstein HB: Intermittent lumbar puncture in rats: A novel method for the experimental study of opioid tolerance. Anesth Analg 2006; 103:714-20.
26. Yaksh TL, Grafe MR, Malkmus S, Rathbun ML, Eisenach JC: Studies on the safety of chronically administered intrathecal neostigmine methylsulfate in rats and dogs. Anesthesiology 1995; 82:412-27.
27. Schorscher-Petcu A, Sotocinal S, Ciura S, Dupré A, Ritchie J, Sorge RE, Crawley JN, Hu SB, Nishimori K, Young LJ, Tribollet E, Quirion R, Mogil JS: Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse. J Neurosci 2010; 30:8274-84.
28. Higuchi H, Hirata J, Adachi Y, Kazama T: Influence of lumbosacral cerebrospinal fluid density, velocity, and volume on extent and duration of plain bupivacaine spinal anesthesia. Anesthesiology 2004; 100:106-14.
29. Walker SM, Yaksh TL: Neuraxial analgesia in neonates and infants: A review of clinical and preclinical strategies for the development of safety and efficacy data. Anesth Analg 2012; 115:638-62.
30. Yaksh TL: Spinal delivery and assessment of drug safety, Fundamental Neuropathology for Pathologists and Toxicologists. Edited by Bolon BB. Hoboken, John Wiley and Sons, 2011, pp 451-62.
31. Eisenach JC, Yaksh TL: Safety in numbers: How do we study toxicity of spinal analgesics? Anesthesiology 2002; 97:1047-9.
32. Yu SQ, Lundeberg T, Yu LC: Involvement of oxytocin in spinal antinociception in rats with inflammation. Brain Res 2003; 983:13-22.
33. Chiari A, Yaksh TL, Myers RR, Provencher J, Moore L, Lee CS, Eisenach JC: Preclinical toxicity screening of intrathecal adenosine in rats and dogs. Anesthesiology 1999; 91:824-32.
34. Yaksh TL, Horais KA, Tozier N, Rathbun M, Richter P, Rossi S, Grafe M, Tong C, Meschter C, Cline JM, Eisenach J: Intrathecal ketorolac in dogs and rats. Toxicol Sci 2004; 80:322-34.
35. Liard JF: Vasopressin in cardiovascular control: Role of circulating vasopressin. Clin Sci (Lond) 1984; 67:473-81.
36. Huang W, Sjöquist M, Skott O, Stricker EM, Sved AF: Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats. Am J Physiol Regul Integr Comp Physiol 2001; 280:R760-5.
37. Gossen A, Hahn A, Westphal L, Prinz S, Schultz RT, Gründer G, Spreckelmeyer KN: Oxytocin plasma concentrations after single intranasal oxytocin administration-A study in healthy men. Neuropeptides 2012; 46:211-5.
38. Hood DD, Eisenach JC, Tuttle R: Phase I safety assessment of intrathecal neostigmine methylsulfate in humans. Anesthesiology 1995; 82:331-43.
39. Uzun M, Yapar K, Uzlu E, Citil M, Erdogan HM: QT interval prolongation and decreased heart rates after intravenous bolus oxytocin injection in male and female conscious rabbits. Gen Physiol Biophys 2007; 26:168-72.