What constitutes a relevant change in high-sensitivity troponin values over serial measurement?

Clinical Chemistry

Volumn 60, Issue 6, 2014, Pages 803-805

  Khalili, Houman ^a   De Lemos, James A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TROPONIN; TROPONIN T;

ACUTE CORONARY SYNDROME; ASSAY; BLOOD SAMPLING; CLINICAL CHEMISTRY; CLINICAL STUDY; EDITORIAL; HEART INFARCTION; HEMODIALYSIS PATIENT; HIGH SENSITIVITY TROPONIN ASSAY; HOSPITAL READMISSION; HUMAN; LIMIT OF DETECTION; LOW RISK PATIENT; MEASUREMENT ACCURACY; PREDICTIVE VALUE; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY;

ACUTE CORONARY SYNDROME; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; MALE; MYOCARDIAL INFARCTION; RENAL DIALYSIS; TROPONIN I; TROPONIN T;

EID: 84901796829     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2014.223669     Document Type: Editorial

References (15)

1. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, et al. Third universal definition of myocardial infarction. Circulation 2012;126:2020-35.
2. Januzzi JL Jr, Bamberg F, Lee H, Truong QA, Nichols JH, Karakas M, et al. High-sensitivity troponin T concentrations in acute chest pain patients evaluated with cardiac computed tomography. Circulation 2010;121:1227-34.
3. de Lemos JA, Drazner MH, Omland T, Ayers CR, Khera A, Rohatgi A, et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 2010;304:2503-12.
4. Gore MO, Seliger SL, Defilippi CR, Nambi V, Christenson RH, Hashim IA, et al. Age- and sex-dependent upper reference limits for the high-sensitivity cardiac troponin T assay. J Am Coll Cardiol 2014;63:1441-8.
5. Korley FK, Jaffe AS. Preparing the United States for high-sensitivity cardiac troponin assays. J Am Coll Cardiol 2013;61:1753-8.
6. Aldous SJ, Richards AM, Cullen L, Than MP. Early dynamic change in high-sensitivity cardiac troponin T in the investigation of acute myocardial infarction. Clin Chem 2011;57:1154-60.
7. Mueller M, Biener M, Vafaie M, Doerr S, Keller T, Blankenberg S, et al. Absolute and relative kinetic changes of high-sensitivity cardiac troponin T in acute coronary syndrome and in patients with increased troponin in the absence of acute coronary syndrome. Clin Chem 2012;58:209-18.
8. Reichlin T, Irfan A, Twerenbold R, Reiter M, Hochholzer W, Burkhalter H, et al. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation 2011;124:136-45.
9. Till K, Tanja Z, Francisco O, Stergios T, Lars L, Christoph S, et al. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA 2011;306:2684-93.
10. Reichlin T, Schindler C, Drexler B, Twerenbold R, Reiter M, Zellweger C, et al. One-hour rule-out and rule-in of acute myocardial infarction using highsensitivity cardiac troponin T. Arch Intern Med 2012;172:1211- 8.
11. Aakre KM, Røraas T, Petersen PH, Svarstad E, Sellevoll H, Skadberg Ø, et al. Weekly and 90-minute biological variations in cardiac troponin T and cardiac troponin I in hemodialysis patients and healthy controls. Clin Chem 2014;60:838-47.
12. Wu AH, Jaffe AS, Apple FS, Jesse RL, Francis GL, Morrow DA, et al. National Academy of Clinical Biochemistry laboratory medicine practice guidelines: use of cardiac troponin and B-type natriuretic peptide or N-terminal proBtype natriuretic peptide for etiologies other than acute coronary syndromes and heart failure. Clin Chem 2007;53:2086-96. (Pubitemid 350197291)
13. Simpson AJ, Potter JM, Koerbin G, Oakman C, Cullen L, Wilkes GJ, et al. Use of observed within-person variation of cardiac troponin in emergency department patients for determination of biological variation and percentage and absolute reference change values. Clin Chem 2014;60:848-54.
14. Bjurman C, Larsson M, Johanson P, Petzold M, Lindahl B, Fu ML, Hammarsten O. Small changes in troponin T levels are common in patients with non-ST-segment elevation myocardial infarction and are linked to higher mortality. J Am Coll Cardiol 2013;62:1231-8.
15. Morrow DA, Bonaca MP. Real world application of 'delta' troponin: diagnostic and prognostic implications. J Am Coll Cardiol 2013;62:1239-41.