Pharmacokinetics of two low-dose levonorgestrel-releasing intrauterine systems and effects on ovulation rate and cervical function: Pooled analyses of phase II and III studies

Fertility and Sterility

Volumn 101, Issue 6, 2014, Pages

  Apter, Dan ^a   Gemzell Danielsson, Kristina ^b   Hauck, Brian ^c   Rosen, Kimberly ^d   Zurth, Christian ^e  

^a Vaestoliitto   (Finland)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF CALGARY   (Canada)

^d BAYER CORPORATION   (United States)

^e BAYER PHARMA AG   (Germany)

Author keywords

Low dose levonorgestrel intrauterine system; pharmacodynamics; pharmacokinetics

Indexed keywords

ESTRADIOL; GESTAGEN; LEVONORGESTREL; PROGESTERONE; SEX HORMONE BINDING GLOBULIN;

ANOVULATION; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG RELEASE; DRUG SAFETY; ENDOMETRIUM; ESTRADIOL BLOOD LEVEL; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LEVONORGESTREL RELEASING INTRAUTERINE SYSTEM; LOW DRUG DOSE; MAXIMUM PLASMA CONCENTRATION; MULTICENTER STUDY (TOPIC); NULLIPARA; OUTCOME ASSESSMENT; OVULATION; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); UTERINE CERVIX MUCUS;

LOW-DOSE LEVONORGESTREL INTRAUTERINE SYSTEM; PHARMACODYNAMICS; PHARMACOKINETICS;

ANOVULATION; CERVIX MUCUS; CERVIX UTERI; CLINICAL TRIALS, PHASE II AS TOPIC; CLINICAL TRIALS, PHASE III AS TOPIC; CONTRACEPTIVE AGENTS, FEMALE; ESTRADIOL; FEMALE; HUMANS; INTRAUTERINE DEVICES, MEDICATED; LEVONORGESTREL; OVULATION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 84901773963     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2014.03.004     Document Type: Article

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