Clonal culture and chemodrug assay of heterogeneous cells (PC3 prostate carcinoma cells) using microfluidic single cell array chips

Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Volumn , Issue , 2009, Pages 21-23

  Chung, Jaehoon ^a,b   Bersano Begey, Tom ^a   Pienta, Ken ^c   Yoon, Euisik ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

Author keywords

Clonal culture; Microfluidic; PC3; Single cell; Subclones

Indexed keywords

CELL CULTURE; INLET FLOW; MICROCHANNELS; MICROFLUIDICS;

PC3; PRESSURE DIFFERENCES; PROSTATE CANCER CELLS; PROSTATE CARCINOMA; SINGLE CELL ASSAYS; SINGLE CELL RESOLUTION; SINGLE CELLS; SUBCLONES;

CLONE CELLS;

EID: 84901771637     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (6)

1. J. P. Geisler, S. L. Rose, H. E. Geisler, G. A. Miller, and M. C. Wiemann, "Drug resistance and tumor heterogeneity," Journal of Gynecologic Oncology, 7, 25 (2002)
2. D. L. Dexter and J. T. Leith, "Tumor Heterogeneity and Drug Resistance," J. of Clinical Oncology, 4, 244 (1986)
3. H. Li, X. Chen, T. Calhoun-Davis, K. Claypool, and D. G. Tang, "PC3 Human Prostate Carcinoma Cell Holoclines Contain Self-renewing Tumor-Initiating Cells," Cancer Research, 68, 1820 (2008).
4. J. Chung, Y.-J. Kim, I.-J. Cho and E. Yoon, "High-Throughput Microfluidic Single Cell Assay Chip Using Hydrodynamic Guiding Structures for Efficient Single Cell Capturing Rate," Proceedings of microTAS, 477 (2008).
5. http://eecs.umich.edu/yoon/research/captureJH.html
6. C. Y. Fan, Y.-C. Tung, S. Takayama, E. Meyhofer and K. Kurabayashi, "Electrically Programmable Surfaces for Configurable Patterning of Cells," Advanced Materials, 20, 1418 (2008)