Scabies Mite Inactive Serine Proteases Are Potent Inhibitors of the Human Complement Lectin Pathway

PLoS Neglected Tropical Diseases

Volumn 8, Issue 5, 2014, Pages

  Reynolds, Simone L ^a   Pike, Robert N ^b   Mika, Angela ^c   Blom, Anna M ^d   Hofmann, Andreas ^e   Wijeyewickrema, Lakshmi C ^b   Kemp, Dave ^a   Fischer, Katja ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^d LUND UNIVERSITY   (Sweden)

^e GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4B; COMPLEMENT COMPONENT C9; LECTIN; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNOSE BINDING LECTIN; RECOMBINANT PROTEIN; SERINE PROTEINASE; COMPLEMENT COMPONENT C1Q;

ARTICLE; BINDING COMPETITION; CIRCULAR DICHROISM; COMPLEMENT ACTIVATION; COMPLEMENT DEPOSITION; COMPLEMENT INHIBITION; COMPLEMENT LECTIN PATHWAY; CONTROLLED STUDY; DNA SEQUENCE; HUMAN; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PICHIA PASTORIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; SARCOPTES SCABIEI; SCABIES; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HOST PATHOGEN INTERACTION; METABOLISM; MOLECULAR GENETICS; MUTATION;

AMINO ACID SEQUENCE; ANIMALS; COMPLEMENT C1Q; COMPLEMENT PATHWAY, MANNOSE-BINDING LECTIN; HOST-PATHOGEN INTERACTIONS; HUMANS; MANNOSE-BINDING LECTIN; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; SARCOPTES SCABIEI; SCABIES; SEQUENCE ALIGNMENT; SERINE PROTEASES;

EID: 84901765199     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0002872     Document Type: Article

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