The changing antibiotic susceptibility of bloodstream infections in the first month of life: Informing antibiotic policies for early- and late-onset neonatal sepsis

Epidemiology and Infection

Volumn 142, Issue 4, 2014, Pages 803-811

  Blackburn, R M ^a,b   Verlander, N Q ^b   Heath, P T ^c   Muller Pebody, B ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

^c ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

Antibiotic resistance; bloodstream infections; neonatal infections

Indexed keywords

AMOXICILLIN; CEFOTAXIME; FLUCLOXACILLIN; GENTAMICIN; PENICILLIN DERIVATIVE; ANTIINFECTIVE AGENT; AMPICILLIN;

AGE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BLOODSTREAM INFECTION; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; ENTEROBACTERIACEAE; ENTEROCOCCUS; ESCHERICHIA COLI; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEWBORN; NEWBORN SEPSIS; NONHUMAN; PRACTICE GUIDELINE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; STREPTOCOCCUS AGALACTIAE; UNITED KINGDOM; BACTEREMIA; BACTERIUM; DRUG EFFECT; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; NEWBORN DISEASE; RISK; ACINETOBACTER; BACTERIUM ISOLATE; EARLY ONSET NEONATAL SEPSIS; GRAM POSITIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; LATE ONSET NEONATAL SEPSIS; MICROCOCCUS; NON PYOGENIC STREPTOCOCCUS; ONSET AGE; PSEUDOMONAS; SEX DIFFERENCE; STENOTROPHOMONAS; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BACTEREMIA; BACTERIA; DRUG RESISTANCE, BACTERIAL; HUMANS; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; MICROBIAL SENSITIVITY TESTS; ODDS RATIO;

EID: 84901722729     PISSN: 09502688     EISSN: 14694409     Source Type: Journal    
DOI: 10.1017/S0950268813001520     Document Type: Article

References (20)

1. Bryce J, et al. WHO estimates of the causes of death in children. Lancet 2005; 365: 1147-1152.
2. Adams-Chapman I, Stoll BJ. Neonatal infection and long-term neurodevelopmental outcome in the preterm infant. Current Opinion in Infectious Diseases 2006; 19: 290-297.
3. Leibovici L, Paul M. Benefit associated with appropriate antibiotic treatment. Clinical Infectious Diseases 2007; 45: 1400-1402.
4. Muller-Pebody B, et al. Empirical treatment of neonatal sepsis: are the current guidelines adequate? Archives of Disease in Childhood - Fetal and Neonatal Edition 2011; 96: F4-8.
5. Newton O, English M. Young infant sepsis: aetiology, antibiotic susceptibility and clinical signs. Transactions of the Royal Society of Tropical Medicine and Hygiene 2007; 101: 959-966.
6. Paediatric Formulary Committee. BNF for Children 2011-2012 (British National Formulary for Children). London: British National Formulary Publications, 2011.
7. Christiansen H, Leth H. Breast milk as a cause of group B streptococcal sepsis. Ugeskrift for Laeger 2011; 173: 129-130.
8. Guerti K, et al. Time to positivity of neonatal blood cultures: fast and furious? Journal of Medical Microbiology 2011; 60: 446-453.
9. van den Hoogen A, et al. Long-term trends in the epidemiology of neonatal sepsis and antibiotic susceptibility of causative agents. Neonatology 2010; 97: 22-28.
10. Centers for Disease Control and Prevention. Prevention of perinatal group B streptococcal disease: a public health perspective. Centers for Disease Control and Prevention. Morbidity and Mortality Weekly Report. Recommendations and Reports 1996; 45: 1-24.
11. National Collaborating Centre for Women's and Children's Health. Antibiotics for Early-onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-onset Neonatal Infection. London: RCOG Press at the Royal College of Obstetricians and Gynaecologists, 2012.
12. Vergnano S, et al. Neonatal infections in England: the NeonIN surveillance network. Archives of Disease in Childhood 2011; 96: F9-F14.
13. Parry GJ, Tucker JS, Tarnow-Mordi WO. Relationship between probable nosocomial bacteraemia and organisational and structural factors in UK neonatal intensive care units. Quality & Safety in Health Care 2005; 14: 264-269.
14. Stoll BJ, et al. Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. Journal of Pediatrics 1996; 129: 63-71.
15. Isaacs D. A ten year, multicentre study of coagulase negative staphylococcal infections in Australasian neonatal units. Archives of Disease in Childhood 2003; 88: F89-F93.
16. Leighton PH. Monitoring blood stream infection in neonatal intensive care units (dissertation). University College London, 2011, 298 pp.
17. Health Protection Agency (HPA). Voluntary reporting of Staphylococcus aureus bacteraemia in England, Wales and Northern Ireland, 2011 (http://www.hpa.org. uk/webw/HPAweb&Page&HPAwebAutoListName/Page/ 1191942169769). Accessed 12 December 2012.
18. Blackburn RM, et al. Neonatal sepsis - many blood samples, few positive cultures: implications for improving antibiotic prescribing. Archives of Disease in Childhood - Fetal and Neonatal Edition 2012; 97: 487-488.
19. Sohn AH, et al. Prevalence of nosocomial infections in neonatal intensive care unit patients: results from the first national point-prevalence survey. Journal of Pediatrics 2001; 139: 821-827.
20. Russell AB, Sharland M, Heath PT. Improving antibiotic prescribing in neonatal unitstime to act. Archives of Disease in Childhood - Fetal and Neonatal Edition 2012; 97; F141-F146.