메뉴 건너뛰기




Volumn 41, Issue 6, 2014, Pages 1049-1060

Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis

Author keywords

Cochrane review; Folic acid; Folinic acid; Rheumatoid arthritis

Indexed keywords

FOLIC ACID; FOLINIC ACID; METHOTREXATE; PLACEBO; ANTIRHEUMATIC AGENT;

EID: 84901712332     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.130738     Document Type: Review
Times cited : (110)

References (31)
  • 1
    • 0029114578 scopus 로고
    • The changing face of therapy for rheumatoid arthritis
    • Kremer J. The changing face of therapy for rheumatoid arthritis. Rheum Dis Clin North Am 1995;21:845-52.
    • (1995) Rheum Dis Clin North Am , vol.21 , pp. 845-852
    • Kremer, J.1
  • 2
    • 0025084541 scopus 로고
    • The comparative efficacy and toxicity of second-line drugs in rheumatoid arthritis: Results of two metaanalyses
    • Felson D, Anderson J, Meenan R. The comparative efficacy and toxicity of second-line drugs in rheumatoid arthritis. Results of two meta-analyses. Arthritis Rheum 1990;33:1449-61. (Pubitemid 20362087)
    • (1990) Arthritis and Rheumatism , vol.33 , Issue.10 , pp. 1449-1461
    • Felson, D.T.1    Anderson, J.J.2    Meenan, R.F.3
  • 4
    • 0023255416 scopus 로고
    • Methotrexate in rheumatoid arthritis
    • Tugwell P, Bennett K, Gent M. Methotrexate in rheumatoid arthritis. Ann Intern Med 1987;107:358-66.
    • (1987) Ann Intern Med , vol.107 , pp. 358-366
    • Tugwell, P.1    Bennett, K.2    Gent, M.3
  • 5
    • 0028226403 scopus 로고
    • Low-dose methotrexate in rheumatic diseases - Efficacy, side effects, and risk factors for side effects
    • DOI 10.1016/0049-0172(94)90027-2
    • Schnabel A, Gross WL. Low-dose methotrexate in rheumatic diseases - efficacy, side effects, and risk factors for side effects. Semin Arthritis Rheum 1994;23:310-27. (Pubitemid 24116664)
    • (1994) Seminars in Arthritis and Rheumatism , vol.23 , Issue.5 , pp. 310-327
    • Schnabel, A.1    Gross, W.L.2
  • 6
    • 0029131045 scopus 로고
    • Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients
    • Leeb BF, Witzmann G, Ogris E, Studnicka-Benke A, Andel I, Schweitzer H, et al. Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 1995;13:459-63.
    • (1995) Clin Exp Rheumatol , vol.13 , pp. 459-463
    • Leeb, B.F.1    Witzmann, G.2    Ogris, E.3    Studnicka-Benke, A.4    Andel, I.5    Schweitzer, H.6
  • 7
    • 0033783023 scopus 로고    scopus 로고
    • Do patients with rheumatoid arthritis established on methotrexate and folic acid 5 mg daily need to continue folic acid supplements long term?
    • Griffith S, Fisher J, Clarke S, Montgomery B, Jones P, Saklatvala J, et al. Do patients with rheumatoid arthritis established on methotrexate and folic acid 5 mg daily need to continue folic acid supplements long term? Rheumatology 2000;39:1102-9.
    • (2000) Rheumatology , vol.39 , pp. 1102-1109
    • Griffith, S.1    Fisher, J.2    Clarke, S.3    Montgomery, B.4    Jones, P.5    Saklatvala, J.6
  • 8
    • 0025887372 scopus 로고
    • Exacerbation of rheumatoid arthritis in patients treated with methotrexate after administration of folinic acid
    • Joyce D, Will D, Hoffman D, Laing B, Blackbourn S. Exacerbation of rheumatoid arthritis in patients treated with methotrexate after administration of folinic acid. Ann Rheum Dis 1991;50:913-4.
    • (1991) Ann Rheum Dis , vol.50 , pp. 913-914
    • Joyce, D.1    Will, D.2    Hoffman, D.3    Laing, B.4    Blackbourn, S.5
  • 9
    • 0023785897 scopus 로고
    • The effects of leucovorin (folinic acid) on methotrexate therapy in rheumatoid arthritis patients
    • Tishler M, Caspi D, Fishel B, Yaron M. The effects of leucovorin (folinic acid) on methotrexate therapy in rheumatoid arthritis patients. Arthritis Rheum 1988;31:906-8.
    • (1988) Arthritis Rheum , vol.31 , pp. 906-908
    • Tishler, M.1    Caspi, D.2    Fishel, B.3    Yaron, M.4
  • 12
    • 45849124232 scopus 로고    scopus 로고
    • BSR/BHPR guideline for disease-modifying anti-rheumatic drug (DMARD) therapy in consultation with the British Association of Dermatologists
    • Chakravarty K, McDonald H, Pullar T, Taggart A, Chalmers R, Oliver S, et al. BSR/BHPR guideline for disease-modifying anti-rheumatic drug (DMARD) therapy in consultation with the British Association of Dermatologists. Rheumatology 2008;47:924-5.
    • (2008) Rheumatology , vol.47 , pp. 924-925
    • Chakravarty, K.1    McDonald, H.2    Pullar, T.3    Taggart, A.4    Chalmers, R.5    Oliver, S.6
  • 13
    • 84901719875 scopus 로고    scopus 로고
    • Dutch Society of Rheumatology. [in Dutch]. [Internet. Accessed March 5, 2014.] Available from
    • Dutch Society of Rheumatology. Guidelines for medication: methotrexate ID - 52, 2009 [in Dutch]. [Internet. Accessed March 5, 2014.] Available from: www.nvrnl/richtlijnen/Totstandkoming-richtlijnen
    • (2009) Guidelines for Medication: Methotrexate ID - 52
  • 15
    • 84859832981 scopus 로고    scopus 로고
    • 2012 Update of the 2008 American College of Rheumatology Recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
    • Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, et al. 2012 Update of the 2008 American College of Rheumatology Recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res 2012;64:625-39.
    • (2012) Arthritis Care Res , vol.64 , pp. 625-639
    • Singh, J.A.1    Furst, D.E.2    Bharat, A.3    Curtis, J.R.4    Kavanaugh, A.F.5    Kremer, J.M.6
  • 16
    • 70049099036 scopus 로고    scopus 로고
    • Chapter 8: Assessing risk of bias in included studies
    • Higgins JPT, Green S, editors. [updated March 2011]. The Cochrane Collaboration, [Internet. Accessed March 5, 2014.] Available from
    • Higgins J, Altman D. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. [Internet. Accessed March 5, 2014.] Available from: www.cochrane-handbook.org
    • (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0
    • Higgins, J.1    Altman, D.2
  • 17
    • 84890740559 scopus 로고    scopus 로고
    • Chapter 11: Presenting results and 'Summary of findings' tables
    • Higgins JPT, Green S, editors. [updated March 2011]. The Cochrane Collaboration, [Internet. Accessed March 5, 2014.] Available from
    • Schünemann HJ, Oxman AD, Higgins JPT, Vist GE, Glasziou P, Guyatt GH. Chapter 11: Presenting results and 'Summary of findings' tables. In: Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. [Internet. Accessed March 5, 2014.] Available from: www.cochrane-handbook. org
    • (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0
    • Schünemann, H.J.1    Oxman, A.D.2    Higgins, J.P.T.3    Vist, G.E.4    Glasziou, P.5    Guyatt, G.H.6
  • 18
    • 84890659505 scopus 로고    scopus 로고
    • Chapter 12: Interpreting results and drawing conclusions
    • Higgins JPT, Green S, editors. [updated March 2011]. The Cochrane Collaboration, [Internet. Accessed March 5, 2014.] Available from
    • Schünemann HJ, Oxman AD, Vist G, Higgins J, Deeks JJ, Glasziou P, et al. Chapter 12: Interpreting results and drawing conclusions. In: Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. [Internet. Accessed March 5, 2014.] Available from: www.cochrane-handbook.org
    • (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0
    • Schünemann, H.J.1    Oxman, A.D.2    Vist, G.3    Higgins, J.4    Deeks, J.J.5    Glasziou, P.6
  • 19
    • 0025092365 scopus 로고
    • Administration of folinic acid after low dose methotrexate in patients with rheumatoid arthritis
    • Buckley L, Vacek P, Cooper S. Administration of folinic acid after low dose methotrexate in patients with rheumatoid arthritis. J Rheumatol 1990;17:1158-61. (Pubitemid 20334691)
    • (1990) Journal of Rheumatology , vol.17 , Issue.9 , pp. 1158-1161
    • Buckley, L.M.1    Vacek, P.M.2    Cooper, S.M.3
  • 21
    • 0028593942 scopus 로고
    • Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo controlled trial
    • Morgan SL, Baggot JE, Vaughn WH, Austin JS, Veitch JA, Lee JY, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo controlled trial. Ann Intern Med 1994;121:833-41.
    • (1994) Ann Intern Med , vol.121 , pp. 833-841
    • Morgan, S.L.1    Baggot, J.E.2    Vaughn, W.H.3    Austin, J.S.4    Veitch, J.A.5    Lee, J.Y.6
  • 23
    • 0035157121 scopus 로고    scopus 로고
    • The C677T mutation in the methylenetetrahydrofolate reductase gene: A genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients
    • DOI 10.1002/1529-0131(200111)44:11<2525::AID-ART43
    • Van Ede A, Laan R, Blom H, Huizinga T, Haagsma C, Giesendorf B, et al. The C677T mutation in the methylenetetrahydrofolate reductase gene. A genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients. Arthritis Rheum 2001;44:2525-30. (Pubitemid 33049330)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.11 , pp. 2525-2530
    • Van Ede, A.E.1    Laan, R.F.J.M.2    Blom, H.J.3    Huizinga, T.W.J.4    Haagsma, C.J.5    Giesendorf, B.A.J.6    De Boo, T.M.7    Van De, P.L.B.A.8
  • 24
    • 0027160604 scopus 로고
    • Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: An 8 week randomized placebo controlled trial
    • Weinblatt ME, Maier AL, Coblyn JS. Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: an 8 week randomized placebo controlled trial. J Rheumatol 1993;20:950-2. (Pubitemid 23203232)
    • (1993) Journal of Rheumatology , vol.20 , Issue.6 , pp. 950-952
    • Weinblatt, M.E.1    Maier, A.L.2    Coblyn, J.S.3
  • 25
    • 84901715782 scopus 로고    scopus 로고
    • updated [Internet. Accessed March 31, 2014.] Available from
    • Methotrexate - clinical pharmacology (updated 2013). [Internet. Accessed March 31, 2014.] Available from: www.drugs.com/pro/methotrexate.html
    • (2013) Methotrexate - Clinical Pharmacology
  • 26
    • 0029614652 scopus 로고
    • Folate supplementation and methotrexate
    • Dijkmans B. Folate supplementation and methotrexate. Br J Rheumatol 1995;34:1172-4. (Pubitemid 26055340)
    • (1995) British Journal of Rheumatology , vol.34 , Issue.12 , pp. 1172-1174
    • Dijkmans, B.A.C.1
  • 27
    • 8544253360 scopus 로고
    • Pharmacologic approaches. SAARDs II
    • Klippel JH, Dieppe PA, editors. London: Mosby; section 8, chapter 13
    • Furst DE, Clements PJ. Pharmacologic approaches. SAARDs II. In: Klippel JH, Dieppe PA, editors. Rheumatology. London: Mosby; 1994:section 8, chapter 13, pp.1-8.
    • (1994) Rheumatology , pp. 1-8
    • Furst, D.E.1    Clements, P.J.2
  • 28
    • 0029055719 scopus 로고
    • Assessing the cost effectiveness of NSAID: An international perspective
    • Drummond M, Bosi Ferraz M, Mason J. Assessing the cost effectiveness of NSAID: an international perspective. J Rheumatol 1995;22:1408-14.
    • (1995) J Rheumatol , vol.22 , pp. 1408-1414
    • Drummond, M.1    Bosi Ferraz, M.2    Mason, J.3
  • 29
    • 0027200401 scopus 로고
    • Folic acid supplementation during methotrexate therapy: It makes sense
    • Morgan S, Alarcón G, Krumdieck C. Folic acid supplementation during methotrexate therapy: it makes sense (editorial). J Rheumatol 1993;20:929-30. (Pubitemid 23203227)
    • (1993) Journal of Rheumatology , vol.20 , Issue.6 , pp. 929-930
    • Morgan, S.L.1    Alarcon, G.S.2    Krumdieck, C.L.3
  • 30
    • 0028593430 scopus 로고
    • Methotrexate: The emerging drug of choice for serious rheumatoid arthritis
    • Salach R, Cash J. Methotrexate: The emerging drug of choice for serious rheumatoid arthritis. Clin Ther 1994;16:912-22.
    • (1994) Clin Ther , vol.16 , pp. 912-922
    • Salach, R.1    Cash, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.