Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin/peroxiredoxin (Trx/Prx) system

Journal of Biological Chemistry

Volumn 289, Issue 22, 2014, Pages 15611-15620

  Lopert, Pamela ^a   Patel, Manisha ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; BRAIN; NUCLEOTIDES; PRASEODYMIUM COMPOUNDS;

ANTI-OXIDANT ACTIVITIES; BRAIN MITOCHONDRIA; MITOCHONDRIAL RESPIRATION; REDUCTASE ACTIVITY; THERAPEUTIC TARGETS; THIOREDOXINS; TRANSHYDROGENASES;

MITOCHONDRIA;

HYDROGEN PEROXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; PEROXIREDOXIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOREDOXIN; THIOREDOXIN REDUCTASE;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CELL DEATH; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DETOXIFICATION; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT;

MITOCHONDRIA; NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE; OXIDATIVE STRESS; PARKINSON DISEASE; REACTIVE OXYGEN SPECIES (ROS); THIOREDOXIN REDUCTASE;

ANIMALS; ANTIOXIDANTS; BRAIN; CELL LINE, TRANSFORMED; DOPAMINERGIC NEURONS; HYDROGEN PEROXIDE; MALE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NADP; NADP TRANSHYDROGENASE, AB-SPECIFIC; OXIDATIVE STRESS; PEROXIREDOXINS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY; THIOREDOXIN REDUCTASE 1; THIOREDOXINS;

EID: 84901704367     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.533653     Document Type: Article

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