Rising rates of proton pump inhibitor prescribing in US emergency departments

American Journal of Emergency Medicine

Volumn 32, Issue 6, 2014, Pages 618-622

  Mazer Amirshahi, Maryann ^a,b   Mullins, Peter M ^a   Van Den Anker, John ^a,b,c,d   Meltzer, Andrew ^a   Pines, Jesse M ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^d UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTACID AGENT; ESOMEPRAZOLE; HISTAMINE H2 RECEPTOR ANTAGONIST; LANSOPRAZOLE; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR; RABEPRAZOLE;

ADULT; AGED; ARTICLE; DEMOGRAPHY; DRUG SAFETY; EMERGENCY WARD; FEMALE; GENDER; HIGH RISK POPULATION; HUMAN; MALE; PRESCRIPTION; PRIORITY JOURNAL; RACE; UNITED STATES; UNSPECIFIED SIDE EFFECT;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ADOLESCENT; ADULT; AGED; EMERGENCY SERVICE, HOSPITAL; FEMALE; HEALTH CARE SURVEYS; HUMANS; MALE; MIDDLE AGED; PATIENT DISCHARGE; PHYSICIAN'S PRACTICE PATTERNS; PROTON PUMP INHIBITORS; UNITED STATES; YOUNG ADULT;

EID: 84901677053     PISSN: 07356757     EISSN: 15328171     Source Type: Journal    
DOI: 10.1016/j.ajem.2014.03.019     Document Type: Article

References (34)

1. M.H. Katz Failing the acid test: benefits of proton pump inhibitors may not justify the risks for many users Arch Intern Med 170 2010 747 748
2. N.S. Abraham Proton pump inhibitors: potential adverse effects Curr Opin Gastroenterol 28 2012 615 620
3. N. Vakil Prescribing proton pump inhibitors: is it time to pause and rethink? Drugs 72 2012 437 445
4. G. Famularo, L. Gasbarrone, and G. Minisola Hypomagnesemia and proton-pump inhibitors Expert Opin Drug Saf 12 2013 709 716
5. E.J. Hoorn, J. van der Hoek, and R.A. de Man et al. A case series of proton pump inhibitor-induced hypomagnesemia Am J Kidney Dis 56 2010 112 116
6. S. Janarthanan, I. Ditah, and D.G. Adler et al. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis Am J Gastroenterol 107 2012 1001 1010
7. S.G. Goodman, R. Clare, and K.S. Pieper et al. Association of proton pump inhibitor use on cardiovascular outcomes with clopidogrel and ticagrelor: insights from the platelet inhibition and patient outcomes trial Circulation 125 2012 978 986
8. E. Ramirez, S.H. Lei, and A.M. Borobia et al. Overuse of PPIs in patients at admission, during treatment, and at discharge in a tertiary Spanish hospital Curr Clin Pharmacol 5 2010 288 297
9. I. Forgacs, and A. Loganayagam Overprescribing proton pump inhibitors BMJ 336 2008 2 3
10. D.A. Zink, M. Pohlman, and M. Barnes et al. Long-term use of acid suppression started inappropriately during hospitalization Aliment Pharmacol Ther 21 2005 1203 1209
11. L. Olbe, T. Lind, and C. Cederberg et al. Effect of omeprazole on gastric acid Scand J Gastroenterol Suppl 118 1986 105 107
12. Centers for Disease Control and Prevention Ambulatory health care data http://www.cdc.gov/nchs/ahcd/about-ahcd.htm [Accessed July 26, 2013]
13. Kaiser Family Foundation Follow the pill: understanding the U.S. commercial pharmaceutical supply chain http://www.avalerehealth.net/research/ docs/Follow-the-Pill.pdf [Accessed November 22, 2013]
14. IMS Institute for HealthCare Informatics The use of medicines in the United States: review of 2010 http://www.imshealth.com/imshealth/Global/Content/ IMS%20Institute/Documents/IHII-UseOfMed-report%20.pdf [Accessed November 22, 2013]
15. Choosing wisely Treating heartburn and GERD http://www.choosingwisely. org/doctor-patient-lists/treating-heartburn-and-gerd [Accessed October 10, 2013]
16. Y.X. Yang, and D.C. Metz Safety of proton pump inhibitor exposure Gastroenterology 139 2010 1115 1127
17. C. Reimer Safety of long-term PPI therapy Best Pract Res Clin Gastroenterol 27 2013 443 454
18. D.L. Bhatt, B.L. Cryer, and C.F. Contant et al. Clopidogrel with or without omeprazole in coronary artery disease N Engl J Med 363 2010 1909 1917
19. L.A. García Rodríguez, and S. Johansson et al. Use of clopidogrel and proton pump inhibitors after a serious acute coronary event: risk of coronary events and peptic ulcer bleeding Thromb Haemost 110 2013 1014 1024
20. B. Huang, Y. Huang, and Y. Li et al. Adverse cardiovascular effects of concomitant use of proton pump inhibitors and clopidogrel in patients with coronary artery disease: a systematic review and meta-analysis Arch Med Res 43 2012 212 224
21. J.F. Tanguay, A.D. Bell, and M.L. Ackman et al. Focused 2012 update of the Canadian cardiovascular society guidelines for the use of antiplatelet therapy Can J Cardiol 29 2013 1334 1345
22. S.K. Mehta, A.D. Frutkin, and J.B. Lindsey et al. Bleeding in patients undergoing percutaneous coronary intervention: the development of a clinical risk algorithm from the national cardiovascular data registry Circ Cardiovasc Interv 2 2009 222 229
23. S. Ngamruengphong, G.I. Leontiadis, and S. Radhi et al. Proton pump inhibitors and risk of fracture: a systematic review and meta-analysis of observational studies Am J Gastroenterol 106 2011 1209 1218
24. S. Janarthanan, I. Ditah, and D.G. Adler et al. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis Am J Gastroenterol 107 2012 1001 1010
25. A.S. Chitnis, S.M. Holzbauer, and R.M. Belflower et al. Epidemiology of community-associated clostridium difficile infection, 2009 through 2011 JAMA Intern Med 173 2013 1359 1367
26. A. Linsky, K. Gupta, and E.V. Lawler et al. Proton pump inhibitors and risk for recurrent Clostridium difficile infection Arch Int Med 170 2010 773 778
27. G.I. Leontiadis, V.K. Sharma, and C.W. Howden Proton pump inhibitor therapy for peptic ulcer bleeding: cochrane collaboration meta-analysis of randomized controlled trials Mayo Clin Proc 82 2007 286 296
28. K.C. Yeh, A.N. Chremos, and J.H. Lin et al. Single-dose pharmacokinetics and bioavailability of famotidine in man. Results of multicenter collaborative studies Biopharm Drug Dispos 8 1987 549 560
29. C. Reimer, B. Sondergaard, and L. Hilsted et al. Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy Gastroenterology 137 2009 80 87 87e1
30. A.B. Lodrup, C. Reimer, and P. Bytzer Systematic review: symptoms of rebound acid hypersecretion following proton pump inhibitor treatment Scand J Gastroenterol 48 2013 515 522
31. 2-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): a primary-care-based randomized controlled trial Lancet 373 2009 215 225
32. A.C. Meltzer, R. Pierce, and D.A. Cummings et al. Rapid (13)C urea breath test to identify helicobacter pylori infection in emergency department patients with upper abdominal pain West J Emerg Med 14 2013 278 282
33. J.M. Mason, A.S. Raghunath, and A.P. Hungin et al. Helicobacter pylori eradication in long-term proton pump inhibitor users is highly cost-effective: economic analysis of the HELPUP trial Aliment Pharmacol Ther 28 2008 1297 1303
34. L.F. McCaig, and C.W. Burt Understanding and interpreting the National Hospital Ambulatory Medical Care Survey: key questions and answers Ann Emerg Med 60 2012 716-21.e1