Phase i study of weekly paclitaxel in combination with pazopanib and lapatinib in advanced solid malignancies

British Journal of Cancer

Volumn 110, Issue 11, 2014, Pages 2647-2654

  Tan, A R ^a   Dowlati, A ^b   Stein, M N ^a   Jones, S F ^c   Infante, J R ^c   Bendell, J ^c   Kane, M P ^a   Levinson, K T ^a   Suttle, A B ^d   Burris Iii, H A ^c  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c SARAH CANNON RESEARCH INSTITUTE   (United States)

^d GLAXOSMITHKLINE   (United States)

Author keywords

EGFR and HER2 tyrosine kinase inhibitor; lapatinib; paclitaxel; pazopanib; vascular endothelial growth factor receptor tyrosine kinase inhibitor

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIHYPERTENSIVE AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; LAPATINIB; PACLITAXEL; PAZOPANIB;

ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANEMIA; ANOREXIA; ANUS CANCER; AREA UNDER THE CURVE; ARTICLE; BILE DUCT CARCINOMA; BILIARY TRACT CANCER; BLADDER CANCER; BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER OF UNKNOWN PRIMARY SITE; CHEMOTHERAPY INDUCED NAUSEA AND VOMITING; CLINICAL ARTICLE; COLORECTAL CANCER; DECREASED APPETITE; DIARRHEA; DIZZINESS; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSGEUSIA; DYSPEPSIA; EPISTAXIS; ESOPHAGUS CANCER; FATIGUE; FEMALE; HEAD AND NECK CANCER; HUMAN; HYPERBILIRUBINEMIA; HYPERTENSION; HYPOALBUMINEMIA; HYPOTHYROIDISM; LARGE INTESTINE PERFORATION; LEUKOPENIA; LUNG NON SMALL CELL CANCER; LYMPHOCYTOPENIA; MALE; MAXIMUM PLASMA CONCENTRATION; MAXIMUM TOLERATED DOSE; MELANOMA; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PERIPHERAL NEUROPATHY; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RASH; SALIVARY GLAND CANCER; SIDE EFFECT; SOLID TUMOR; THROMBOCYTOPENIA; THROMBOSIS; THYMUS CANCER; TREATMENT RESPONSE;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BILIARY TRACT NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; PACLITAXEL; PYRIMIDINES; QUINAZOLINES; SALIVARY GLAND NEOPLASMS; SULFONAMIDES; TREATMENT OUTCOME;

EID: 84901623888     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.233     Document Type: Article

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