LCPUFAs as Conditionally Essential Nutrients for Very Low Birth Weight and Low Birth Weight Infants. Metabolic, Functional, and Clinical Outcomes-How Much is Enough?

Clinics in Perinatology

Volumn 41, Issue 2, 2014, Pages 451-461

  Makrides, Maria ^a,b   Uauy, Ricardo ^c  

^a SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Development; LCPUFA; Low birth weight infants; Preterm; Randomized controlled trials; Very low birth weight infants

Indexed keywords

DOCOSAHEXAENOIC ACID; LONG CHAIN FATTY ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID;

ARTICLE; ARTIFICIAL MILK; BIOACCUMULATION; BIRTH WEIGHT; BREAST MILK; CHILD DEVELOPMENT; COGNITION; DEVELOPMENTAL DISORDER; DIET SUPPLEMENTATION; ESSENTIAL FATTY ACID DEFICIENCY; EYE DEVELOPMENT; FAT INTAKE; FATTY ACID METABOLISM; FOOD COMPOSITION; GESTATIONAL AGE; GROWTH RETARDATION; HUMAN; HYPOXIA; IMMATURITY; INFANT; INFANT NUTRITION; INFLAMMATION; INTRAUTERINE GROWTH RETARDATION; ISCHEMIA; LIPID STORAGE; LOW BIRTH WEIGHT; LUNG DYSPLASIA; MENTAL PERFORMANCE; NECROTIZING ENTEROCOLITIS; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NUTRITIONAL REQUIREMENT; PREMATURE LABOR; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK REDUCTION; SEPSIS; THIRD TRIMESTER PREGNANCY; VERY LOW BIRTH WEIGHT; VISUAL DISORDER; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NEWBORN; PROGNOSIS;

DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; HUMANS; INFANT FORMULA; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, VERY LOW BIRTH WEIGHT; PROGNOSIS;

EID: 84901587059     PISSN: 00955108     EISSN: 15579840     Source Type: Journal    
DOI: 10.1016/j.clp.2014.02.012     Document Type: Review

References (27)

1. Innis S.M. Essential fatty acid transfer and fetal development. Placenta 2005, 26(Suppl A):S70-S75.
2. Lapillonne A., Jensen C.L. Reevaluation of the DHA requirement for the premature infant. Prostaglandins Leukot Essent Fatty Acids 2009, 81:143-150.
3. Lapillonne A., Groh-Wargo S., Gonzalez C.H., et al. Lipid needs of preterm infants: updated recommendations. J Pediatr 2013, 162:S37-S47.
4. Uauy R.D., Birch D.G., Birch E.E., et al. Effect of dietary omega-3 fatty acids on retinal function of very-low-birth-weight neonates. Pediatr Res 1990, 28:485-492.
5. Birch E.E., Birch D.G., Hoffman D.R., et al. Dietary essential fatty acid supply and visual acuity development. Invest Ophthalmol Vis Sci 1992, 33:3242-3253.
6. Neuringer M., Connor W.E., Lin D.S., et al. Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci U S A 1986, 83:4021-4025.
7. Neuringer M., Connor W.E., Van Petten C., et al. Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. J Clin Invest 1984, 73:272-276.
8. Schulzke S.M., Patole S.K., Simmer K. Long-chain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst Rev 2011, (2). CD000375.
9. Carlson S.E., Werkman S.H., Rhodes P.G., et al. Visual-acuity development in healthy preterm infants: effect of marine-oil supplementation. Am J Clin Nutr 1993, 58:35-42.
10. O'Connor D.L., Hall R., Adamkin D., et al. Growth and development in preterm infants fed long-chain polyunsaturated fatty acids: a prospective, randomized controlled trial. Pediatrics 2001, 108:359-371.
11. Llanos A., Lin Y., Mena P., et al. Infants with intrauterine growth restriction have impaired formation of docosahexaenoic acid in early neonatal life: a stable isotope study. Pediatr Res 2005, 58:735-740.
12. Uauy R., Hoffman D.R., Mena P., et al. Term infant studies of DHA and ARA supplementation on neurodevelopment: results of randomized controlled trials. J Pediatr 2003, 143:S17-S25.
13. van Wezel-Meijler G., van der Knaap M.S., Huisman J., et al. Dietary supplementation of long-chain polyunsaturated fatty acids in preterm infants: effects on cerebral maturation. Acta Paediatr 2002, 91:942-950.
14. Fewtrell M.S., Morley R., Abbott R.A., et al. Double-blind, randomized trial of long-chain polyunsaturated fatty acid supplementation in formula fed to preterm infants. Pediatrics 2002, 110:73-82.
15. Fewtrell M.S., Abbott R.A., Kennedy K., et al. Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants. J Pediatr 2004, 144:471-479.
16. Clandinin M.T., Van Aerde J.E., Merkel K.L., et al. Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid. J Pediatr 2005, 146:461-468.
17. Fang P.C., Kuo H.K., Huang C.B., et al. The effect of supplementation of docosahexaenoic acid and arachidonic acid on visual acuity and neurodevelopment in larger preterm infants. Chang Gung Med J 2005, 28:708-715.
18. Carlson S.E., Cooke R.J., Werkman S.H., et al. First year growth of preterm infants fed standard compared to marine oil n-3 supplemented formula. Lipids 1992, 27:901-907.
19. Smithers L.G., Gibson R.A., McPhee A.J., et al. Effect of LCPUFA supplementation of preterm infants on disease risk and neurodevelopment: a systematic review of randomised controlled trials. Am J Clin Nutr 2008, 87:912-920.
20. Isaacs E.B., Ross S., Kennedy K., et al. 10-year cognition in preterms after random assignment to fatty acid supplementation in infancy. Pediatrics 2011, 128:e890-e898.
21. Bazan N.G., Molina M.F., Gordon W.C. Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. Annu Rev Nutr 2011, 31:321-351.
22. Henriksen C., Haugholt K., Lindgren M., et al. Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid. Pediatrics 2008, 121:1137-1145.
23. Makrides M., Gibson R.A., McPhee A.J., et al. Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid: a randomized controlled trial. JAMA 2009, 301:175-182.
24. Westerberg A.C., Schei R., Henriksen C., et al. Attention among very low birth weight infants following early supplementation with docosahexaenoic and arachidonic acid. Acta Paediatr 2011, 100:47-52.
25. Manley B.J., Makrides M., Collins C.T., et al. High-dose docosahexaenoic acid supplementation of preterm infants: respiratory and allergy outcomes. Pediatrics 2011, 128:e71-e77.
26. Smithers L.G., Gibson R.A., McPhee A., et al. Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial. Am J Clin Nutr 2008, 88:1049-1056.
27. Collins C.T., Makrides M., Gibson R.A., et al. Pre- and post-term growth in pre- term infants supplemented with higher-dose DHA: a randomised controlled trial. Br J Nutr 2011, 105(11):1635-1643.