-
1
-
-
0037379650
-
A placobo-controlled doubleblind randomized trial in patients with amyotrophic lateral sclerosis with creatine monohydrate: A randomized sequential trial
-
Groeneveld GJ, Veldink JH, van der Tweel I, Kalmijn S, Beijer C, de Visser M, et al. A placobo-controlled doubleblind randomized trial in patients with amyotrophic lateral sclerosis with creatine monohydrate: A randomized sequential trial. Ann Neurol. 2003;53:437-45
-
(2003)
Ann Neurol
, vol.53
, pp. 437-445
-
-
Groeneveld, G.J.1
Veldink, J.H.2
Van Der Tweel, I.3
Kalmijn, S.4
Beijer, C.5
De Visser, M.6
-
2
-
-
77950628380
-
Northeast and canadian amyotrophic lateral sclerosis consortia safety and effi cacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: A randomized, double-blind, placebo-controlled trial
-
Aggarwal SP, Zinman L, Simpson E, McKinley J, Jackson KE, Pinto H, et al .; Northeast and Canadian Amyotrophic Lateral Sclerosis consortia. Safety and effi cacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: A randomized, double-blind, placebo-controlled trial. Lancet Neurol. 2010;9:481-8
-
(2010)
Lancet Neurol
, vol.9
, pp. 481-488
-
-
Aggarwal, S.P.1
Zinman, L.2
Simpson, E.3
McKinley, J.4
Jackson, K.E.5
Pinto, H.6
-
3
-
-
84859718510
-
Lithium lacks effect on survival in amyotrophic lateral sclerosis: A phase IIb randomized sequential trial
-
Verstraete E, Veldink JH, Huisman MH, Draak T, Uijtendaal EV, van der Kooi AJ, et al. Lithium lacks effect on survival in amyotrophic lateral sclerosis: A phase IIb randomized sequential trial. J Neurol Neurosurg Psychiatry. 2012;83:557-64
-
(2012)
J Neurol Neurosurg Psychiatry
, vol.83
, pp. 557-564
-
-
Verstraete, E.1
Veldink, J.H.2
Huisman, M.H.3
Draak, T.4
Uijtendaal, E.V.5
Van Der Kooi, A.J.6
-
4
-
-
84875273042
-
Lithium in patients with amyotrophic lateral sclerosis (LiCALS): A phase III multicentre, randomized, double-blind, placebocontrolled trial
-
UKMND-LiCALS Study Group.
-
UKMND-LiCALS Study Group, Morrison KE, Dhariwal S, Hornabrook R, Savage L, Burn DJ, et al. Lithium in patients with amyotrophic lateral sclerosis (LiCALS): A phase III multicentre, randomized, double-blind, placebocontrolled trial. Lancet Neurology. 2013;12:339-45
-
(2013)
Lancet Neurology
, vol.12
, pp. 339-345
-
-
Morrison, K.E.1
Dhariwal, S.2
Hornabrook, R.3
Savage, L.4
Burn, D.J.5
-
5
-
-
70249116820
-
Phase II trial of CoQ10 for ALS fi nds insuffi cient evidence to justify phase III
-
QALS Study Group
-
Kaufmann P, Thompson JL, Levy G, Buchsbaum R, Shefner J, Krivickas LS, et al .; QALS Study Group. Phase II trial of CoQ10 for ALS fi nds insuffi cient evidence to justify phase III. Ann Neurol. 2009;66:235-44
-
(2009)
Ann Neurol
, vol.66
, pp. 235-244
-
-
Kaufmann, P.1
Thompson, J.L.2
Levy, G.3
Buchsbaum, R.4
Shefner, J.5
Krivickas, L.S.6
-
6
-
-
84870915451
-
Adaptive design across stages of therapeutic development
-
Ravina B, Cummings J, McDermott M, Poole RM. Cambridge: Cambridge University Press
-
Coffey C S. Adaptive Design Across Stages of Therapeutic Development. In: Ravina B, Cummings J, McDermott M, Poole RM. Clinical Trials in Neurology: Design, Conduct, and Analysis. Cambridge: Cambridge University Press;2012. pp 91-100
-
(2012)
Clinical Trials in Neurology: Design, Conduct, and Analysis
, pp. 91-100
-
-
Coffey, C.S.1
-
7
-
-
33750854113
-
Adaptive seamless phase II/III designs-Background, operational aspects, and examples
-
Maca J, Bhattacharya S, Dragalin V, Gallo P, Krams M. Adaptive seamless phase II/III designs: Background operational aspects and examples. Drug Inf J. 2006;40:463-73. (Pubitemid 44721124
-
(2006)
Drug Information Journal
, vol.40
, Issue.4
, pp. 463-473
-
-
Maca, J.1
Bhattacharya, S.2
Dragalin, V.3
Gallo, P.4
Krams, M.5
-
8
-
-
84876243023
-
Northeast als consortium design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis
-
Berry JD, Shefner JM, Conwit R, Schoenfeld D, Keroack M, Felsenstein D, et al ., Northeast ALS Consortium. Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis. PLoS One. 2013;8:e61177
-
(2013)
PLoS One
, vol.8
-
-
Berry, J.D.1
Shefner, J.M.2
Conwit, R.3
Schoenfeld, D.4
Keroack, M.5
Felsenstein, D.6
-
9
-
-
84901488773
-
-
NeuroNEXT.org http://www.neuronext.org/ Viewed online 23 July 2013
-
(2013)
NeuroNEXT.org
-
-
-
11
-
-
66349125688
-
Adaptive patient enrichment designs in therapeutic trials
-
Wang SJ, Hung H MJ, O ' N eill R T. A daptive patient enrichment designs in therapeutic trials. Biometrical J. 2009;51:358-74
-
(2009)
Biometrical J.
, vol.51
, pp. 358-374
-
-
Wang, S.J.1
Hung, H.M.J.2
O'Neill, R.T.3
-
12
-
-
84865987121
-
Modulating infl ammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
-
Butovsky O, Siddiqui S, Gabriely G, Lanser AJ, Dake B, Murugaiyan G, et al. Modulating infl ammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest. 2012;122:3063-87
-
(2012)
J Clin Invest
, vol.122
, pp. 3063-3087
-
-
Butovsky, O.1
Siddiqui, S.2
Gabriely, G.3
Lanser, A.J.4
Dake, B.5
Murugaiyan, G.6
-
14
-
-
79960890098
-
Motor Unit Number Index (MUNIX): Reference values of fi ve different muscles in healthy subjects from a multicentre study
-
Neuwirth C, Nandedkar S, S t ål berg E, Barkhaus PE, Carvalho MD, Furtula J, et al. Motor Unit Number Index (MUNIX): Reference values of fi ve different muscles in healthy subjects from a multicentre study. Clin Neurophysiol. 2011;122:1895-8
-
(2011)
Clin Neurophysiol
, vol.122
, pp. 1895-1898
-
-
Neuwirth, C.1
Nandedkar, S.2
Stålberg, E.3
Barkhaus, P.E.4
Carvalho, M.D.5
Furtula, J.6
-
15
-
-
35148849247
-
Electrical impedance myography to assess outcome in amyotrophic lateral sclerosis clinical trials
-
R utkove SB, Zhang H, Schoenfeld DA, Raynor EM, Shefner JM, Cudkowicz ME, et al. Electrical impedance myography to assess outcome in amyotrophic lateral sclerosis clinical trials. Clin Neurophysiol. 2007;118:2413-8
-
(2007)
Clin Neurophysiol
, vol.118
, pp. 2413-2418
-
-
Rutkove, S.B.1
Zhang, H.2
Schoenfeld, D.A.3
Raynor, E.M.4
Shefner, J.M.5
Cudkowicz, M.E.6
-
16
-
-
84860690620
-
Can the fl ow of medicines be improved?. Fundamental pharmacokinetic and pharmacological principles toward improving phase II survival
-
Morgan P, van der Graaf PH, Arrowsmith J, Feltner DE, Drummond KS, Wegner CD, et al. Can the fl ow of medicines be improved?. Fundamental pharmacokinetic and pharmacological principles toward improving phase II survival. Drug Discov Today. 2012;17:419-24
-
(2012)
Drug Discov Today
, vol.17
, pp. 419-424
-
-
Morgan, P.1
Van Der Graaf, P.H.2
Arrowsmith, J.3
Feltner, D.E.4
Drummond, K.S.5
Wegner, C.D.6
-
17
-
-
36148960127
-
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: A phase III randomised trial
-
DOI 10.1016/S1474-4422(07)70270-3, PII S1474442207702703
-
Gordon PH, Moore DH, Miller RG, Florence JM, Verheijde JL, Doorish C, et al. Effi cacy of minocycline in patients with amyotrophic lateral sclerosis: A phase III randomized trial. Lancet Neurol. 2007;6:1045-53. (Pubitemid 350116691.
-
(2007)
Lancet Neurology
, vol.6
, Issue.12
, pp. 1045-1053
-
-
Gordon, P.H.1
Moore, D.H.2
Miller, R.G.3
Florence, J.M.4
Verheijde, J.L.5
Doorish, C.6
Hilton, J.F.7
Spitalny, G.M.8
MacArthur, R.B.9
Mitsumoto, H.10
Neville, H.E.11
Boylan, K.12
Mozaffar, T.13
Belsh, J.M.14
Ravits, J.15
Bedlack, R.S.16
Graves, M.C.17
McCluskey, L.F.18
Barohn, R.J.19
Tandan, R.20
more..
|