Relationship between exercise behavior, cardiorespiratory fitness, and cognitive function in early breast cancer patients treated with doxorubicin-containing chemotherapy: A pilot study

Applied Physiology, Nutrition and Metabolism

Volumn 39, Issue 6, 2014, Pages 724-729

  Crowgey, Theresa ^a   Peters, Katherine B ^a   Hornsby, Whitney E ^a   Lane, Amy ^a   McSherry, Frances ^a   Herndon II, James E ^a   West, Miranda J ^a   Williams, Christina L ^b   Jones, Lee W ^a,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

^c DUKE CANCER INSTITUTE   (United States)

Author keywords

Adjuvant therapy; Breast cancer; Late effects; Neurocognition

Indexed keywords

DOXORUBICIN;

ADULT; AGED; BREAST NEOPLASMS; CASE CONTROL STUDY; COGNITION; EXERCISE; EXERCISE TEST; FEMALE; FITNESS; HUMAN; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PILOT STUDY; QUESTIONNAIRE; SELF REPORT;

ADULT; AGED; BREAST NEOPLASMS; CASE-CONTROL STUDIES; COGNITION; DOXORUBICIN; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; MIDDLE AGED; PHYSICAL FITNESS; PILOT PROJECTS; SELF REPORT; SURVEYS AND QUESTIONNAIRES;

EID: 84901482619     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/apnm-2013-0380     Document Type: Article

References (40)

1. American College of Sports Medicine. 2013. American College of Sports Medicine's guidelines for exercise testing and prescription. Wolters Kluwer/ Lippincott Williams & Wilkins.
2. ATS/ACCP. 2003. ATS/ACCP Statement on cardiopulmonary exercise testing. Am. J. Respir. Crit. Care Med. 167(2): 211-277. doi:10.1164/rccm.167.2.211. PMID: 12524257.
3. Ahles, T.A., Saykin, A.J., Furstenberg, C.T., Cole, B., Mott, L.A., Skalla, K., et al. 2002. Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. J. Clin. Oncol. 20(2): 485-493. doi:10.1200/JCO.20.2.485. PMID:11786578.
4. Angevaren, M., Aufdemkampe, G., Verhaar, H.J., Aleman, A., and Vanhees, L. 2008. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev. 3: CD005381. PMID:18646126.
5. Brezden, C.B., Phillips, K.A., Abdolell, M., Bunston, T., and Tannock, I.F. 2000. Cognitive function in breast cancer patients receiving adjuvant chemotherapy. J. Clin. Oncol. 18(14): 2695-2701. PMID:10894868.
6. Day, R., Ganz, P.A., Costantino, J.P., Cronin, W.M., Wickerham, D.L., and Fisher, B. 1999. Health-related quality of life and tamoxifen in breast cancer prevention: a report from the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J. Clin. Oncol. 17(9): 2659-2669. PMID:10561339.
7. DeFina, L.F., Willis, B.L., Radford, N.B., Gao, A., Leonard, D., Haskell, W.L., et al. 2013. The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study. Ann. Intern. Med. 158(3): 162-168. doi:10. 7326/0003-4819-158-3-201302050-00005. PMID:23381040.
8. Deprez, S., Amant, F., Smeets, A., Peeters, R., Leemans, A., Van Hecke, W., et al. 2012. Longitudinal assessment of chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning. J. Clin. Oncol. 30(3): 274-281. doi:10.1200/JCO.2011.36.8571. PMID: 22184379.
9. Dishman, R.K., Berthoud, H.R., Booth, F.W., Cotman, C.W., Edgerton, V.R., Fleshner, M.R., et al. 2006. Neurobiology of exercise. Obesity (Silver Spring), 14(3): 345-356. doi:10.1038/oby.2006.46.
10. Ganz, P.A., Day, R., Ware, J.E., Jr., Redmond, C., and Fisher, B. 1995. Base-line quality-of-life assessment in the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial. J. Natl. Cancer Inst. 87(18): 1372-1382. doi:10.1093/jnci/87.18.1372. PMID:7658498.
11. Ganz, P.A., Rowland, J.H., Desmond, K., Meyerowitz, B.E., and Wyatt, G.E. 1998. Life after breast cancer: understanding women's health-related quality of life and sexual functioning. J. Clin. Oncol. 16(2): 501-514. PMID:9469334.
12. Godin, G., and Shephard, R.J. 1985. A simple method to assess exercise behavior in the community. J. Can. Sci. Appl. Sport. 10(3): 141-146. PMID:4053261.
13. Goodwin, P.J., Black, J.T., Bordeleau, L.J., and Ganz, P.A. 2003. Health-related quality-of-life measurement in randomized clinical trials in breast cancer-taking stock. J. Natl. Cancer Inst. 95(4): 263-281. doi:10.1093/jnci/95.4.263. PMID:12591983.
14. Gualtieri, C.T., and Johnson, L.G. 2006. Reliability and validity of a computerized neurocognitive test battery, CNS Vital Signs. Arch. Clin. Neuropsychol. 21(7): 623-643. doi:10.1016/j.acn.2006.05.007. PMID:17014981.
15. Hamer, M., and Chida, Y. 2009. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol. Med. 39(1): 3-11. doi:10.1017/S0033291708003681. PMID:18570697.
16. Hayes, S.M., Hayes, J.P., Cadden, M., and Verfaellie, M. 2013. A review of cardiorespiratory fitness-related neuroplasticity in the aging brain. Front. Aging Neurosci. 5: 31. PMID:23874299.
17. Herrero, F., San Juan, A.F., Fleck, S.J., Foster, C., and Lucia, A. 2007. Effects of detraining on the functional capacity of previously trained breast cancer survivors. Int. J. Sports Med. 28(3): 257-264. doi:10.1055/s-2006-924348. PMID: 17111322.
18. Irwin, M.L., Crumley, D., McTiernan, A., Bernstein, L., Baumgartner, R., Gilliland, F.D., et al. 2003. Physical activity levels before and after a diagnosis of breast carcinoma: the Health, Eating, Activity, and Lifestyle (HEAL) study. Cancer, 97(7): 1746-1757. doi:10.1002/cncr.11227. PMID:12655532.
19. Jim, H.S., Phillips, K.M., Chait, S., Faul, L.A., Popa, M.A., Lee, Y.H., et al. 2012. Meta-analysis of cognitive functioning in breast cancer survivors previously treated with standard-dose chemotherapy. J. Clin. Oncol. 30(29): 3578-3587. doi:10.1200/JCO.2011.39.5640. PMID:22927526.
20. Jones, L.W., Eves, N.D., Haykowsky, M., Freedland, S.J., and Mackey, J.R. 2009. Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction. Lancet Oncol. 10(6): 598-605. doi:10.1016/S1470-2045(09)70031-2. PMID:19482248.
21. Jones, L.W., Courneya, K.S., Mackey, J.R., Muss, H.B., Pituskin, E.N., Scott, J.M., et al. 2012a. Cardiopulmonary function and age-related decline across the breast cancer survivorship continuum. J. Clin. Oncol. 30(20): 2530-2537. doi: 10.1200/JCO.2011.39.9014. PMID:22614980.
22. Jones, L.W., Courneya, K.S., Mackey, J.R., Muss, H.B., Pituskin, E.N., Scott, J.M., et al. 2012b. Cardiopulmonary function and age-related decline across the breast cancer survivorship continuum. J. Clin. Oncol. 30(20): 2530-2537. doi: 10.1200/JCO.2011.39.9014. PMID:22614980.
23. Kesler, S.R., Wefel, J.S., Hosseini, S.M., Cheung, M., Watson, C.L., and Hoeft, F. 2013. Default mode network connectivity distinguishes chemotherapytreated breast cancer survivors from controls. Proc. Natl. Acad. Sci. U.S.A. 110(28): 11600-11605. doi:10.1073/pnas.1214551110. PMID:23798392.
24. Koppelmans, V., Breteler, M.M., Boogerd, W., Seynaeve, C., Gundy, C., and Schagen, S.B. 2012. Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy. J. Clin. Oncol. 30(10): 1080-1086. doi:10.1200/JCO.2011.37.0189. PMID:22370315.
25. Lakoski, S.G., Barlow, C.E., Koelwyn, G.J., Hornsby, W.E., Hernandez, J., DeFina, L.F., et al. 2013. The influence of adjuvant therapy on cardiorespiratory fitness in early-stage breast cancer seven years after diagnosis: the Cooper Center Longitudinal Study. Breast Cancer Res. Treat. 138(3): 909-916. doi:10.1007/s10549-013-2478-1. PMID:23504137.
26. Land, S.R., Wickerham, D.L., Costantino, J.P., Ritter, M.W., Vogel, V.G., Lee, M., et al. 2006. Patient-reported symptoms and quality of life during treatment with tamoxifen or raloxifene for breast cancer prevention: the NSABP study of Tamoxifen and Raloxifene (STAR) P-2 trial. Jama, 295(23): 2742-2751. doi: 10.1001/jama.295.23.joc60075. PMID:16754728.
27. Laurin, D., Verreault, R., Lindsay, J., MacPherson, K., and Rockwood, K. 2001. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 58(3): 498-504. doi:10.1001/archneur.58.3.498. PMID: 11255456.
28. Milne, H.M., Gordon, S., Guilfoyle, A., Wallman, K.E., and Courneya, K.S. 2007. Association between physical activity and quality of life among western Australian breast cancer survivors. Psycho-Oncology, 16(12): 1059-1068. doi:10. 1002/pon.1211. PMID:17549801.
29. Phillips, K.M., Jim, H.S., Small, B.J., Laronga, C., Andrykowski, M.A., and Jacobsen, P.B. 2012. Cognitive functioning after cancer treatment: a 3-year longitudinal comparison of breast cancer survivors treated with chemotherapy or radiation and noncancer controls. Cancer, 118(7): 1925-1932. doi:10. 1002/cncr.26432. PMID:22161750.
30. Roig, M., Nordbrandt, S., Geertsen, S.S., and Nielsen, J.B. 2013. The effects of cardiovascular exercise on human memory: a review with meta-analysis. Neurosci, Biobehav, Rev. 37(8): 1645-1666. doi:10.1016/j.neubiorev.2013.06. 012. PMID:23806438.
31. Scarmeas, N., Luchsinger, J.A., Schupf, N., Brickman, A.M., Cosentino, S., Tang, M.X., and Stern, Y. 2009. Physical activity, diet, and risk of Alzheimer disease. Jama, 302(6): 627-637. doi:10.1001/jama.2009.1144. PMID:19671904.
32. Schagen, S.B., Hamburger, H.L., Muller, M.J., Boogerd, W., and van Dam, F.S. 2001. Neurophysiological evaluation of late effects of adjuvant high-dose chemotherapy on cognitive function. J. Neuro-Oncol. 51(2): 159-165. doi:10. 1023/A:1010635229762. PMID:11386413.
33. Schmidt, W., Endres, M., Dimeo, F., and Jungehulsing, G.J. 2013. Train the vessel, gain the brain: physical activity and vessel function and the impact on stroke prevention and outcome in cerebrovascular disease. Cerebrovasc. Dis. 35(4): 303-312. doi:10.1159/000347061. PMID:23594423.
34. Schmitz, K.H., and Speck, R.M. 2010. Risks and benefits of physical activity among breast cancer survivors who have completed treatment. Womens Health (Lond.), 6(2): 221-238. doi:10.2217/whe.10.1.
35. Schmitz, K.H., Courneya, K.S., Matthews, C., Demark-Wahnefried, W., Galvão, D.A., Pinto, B.M., et al; American College of Sports Medicine. 2010. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med. Sci. Sports Exerc. 42(7): 1409-1426. doi:10.1249/MSS. 0b013e3181e0c112. PMID:20559064.
36. Scott, J.M., Koelwyn, G.J., Hornsby, W.E., Khouri, M., Peppercorn, J., Douglas, P.S., and Jones, L.W. 2013. Exercise therapy as treatment for cardiovascular and oncologic disease after a diagnosis of early-stage cancer. Semin. Oncol. 40(2): 218-228. doi:10.1053/j.seminoncol.2013.01.001. PMID:23540747.
37. Siegel, R., Naishadham, D., and Jemal, A. 2013. Cancer statistics, 2013. CA Cancer J. Clin. 63(1): 11-30. doi:10.3322/caac.21166. PMID:23335087.
38. van den Bent, M.J., Wefel, J.S., Schiff, D., Taphoorn, M.J., Jaeckle, K., Junck, L., et al. 2011. Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas. Lancet Oncol. 12(6): 583-593. doi:10.1016/S1470-2045(11)70057-2. PMID:21474379.
39. Wefel, J.S., Lenzi, R., Theriault, R.L., Davis, R.N., and Meyers, C.A. 2004. The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial. Cancer, 100(11): 2292-2299. doi:10.1002/cncr.20272. PMID:15160331.
40. Wong-Goodrich, S.J., Pfau, M.L., Flores, C.T., Fraser, J.A., Williams, C.L., and Jones, L.W. 2010. Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation. Cancer Res. 70(22): 9329-9338. doi:10.1158/0008-5472.CAN-10-1854. PMID:20884629.