Prognostic significance of nemo-like kinase in nasopharyngeal carcinoma

Molecular Medicine Reports

Volumn 10, Issue 1, 2014, Pages 131-136

  Chen, Size ^a,b   Ma, Zhijian ^c   Chen, Xuemei ^a   Zhang, Jiren ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Biomarker; Nasopharyngeal carcinoma; Nemo like kinase; Prognosis

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NEMO LIKE KINASE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; NLK PROTEIN, HUMAN; SIGNAL PEPTIDE;

ADOLESCENT; ADULT; ARTICLE; CANCER MORTALITY; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CHILD; CLINICAL FEATURE; CORRELATION ANALYSIS; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; OVERALL SURVIVAL; PROTEIN EXPRESSION; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; MORTALITY; NASOPHARYNGEAL NEOPLASMS; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; YOUNG ADULT;

ADOLESCENT; ADULT; CHILD; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROTEIN-SERINE-THREONINE KINASES; YOUNG ADULT;

EID: 84901461650     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2190     Document Type: Article

References (13)

1. Wei KR, Xu Y, Liu J, Zhang WJ and Liang ZH: Histopathological classification of nasopharyngeal carcinoma. Asian Pac J Cancer Prev 12: 1141-1147, 2011.
2. Zhen Y, Ye Y, Yu X, Mai C, Zhou Y, Chen Y, Yang H, Lyu X, Song Y, Wu Q, Fu Q, Zhao M, Hua S, Wang H, Liu Z, Zhang Y and Fang W: Reduced CTGF expression promotes cell growth, migration, and invasion in nasopharyngeal carcinoma. PLoS One 8: e64976, 2013.
3. Ho FC, Tham IW, Earnest A, Lee KM and Lu JJ: Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer 12: 98, 2012.
4. Jia WH and Qin HD: Non-viral environmental risk factors for nasopharyngeal carcinoma: a systematic review. Semin Cancer Biol 22: 117-126, 2012.
5. Brott BK, Pinsky BA and Erikson RL: NLK is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus. Proc Natl Acad Sci USA 95: 963-968, 1998. (Pubitemid 28124895)
6. Jung KH, Kim JK, Noh JH, Eun JW, Bae HJ, Xie HJ, Ahn YM, Park WS, Lee JY and Nam SW: Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma. J Cell Biochem 110: 687-696, 2010.
7. Tan Z, Li M, Wu W, Zhang L, Ding Q, Wu X, Mu J and Liu Y: NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells. Mol Cell Biochem 369: 27-33, 2012.
8. Li M, Zhang S, Wang Z, Zhang B, Wu X, Weng H, Ding Q, Tan Z, Zhang N, Mu J, Yang J, Shu Y, Bao R, Ding Q, Wu W, Cao Y and Liu Y: Prognostic significance of nemo-like kinase (NLK) expression in patients with gallbladder cancer. Tumour Biol: Jul 16, 2013 (Epub ahead of print).
9. Morikawa T, Kuchiba A, Qian ZR, Mino-Kenudson M, Hornick JL, Yamauchi M, Imamura Y, Liao X, Nishihara R, Meyerhardt JA, Fuchs CS and Ogino S: Prognostic significance and molecular associations of tumor growth pattern in colorectal cancer. Ann Surg Oncol 19: 1944-1953, 2012.
10. Morikawa T, Kuchiba A, Yamauchi M, Meyerhardt JA, Shima K, Nosho K, Chan AT, Giovannucci E, Fuchs CS and Ogino S: Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer. JAMA 305: 1685-1694, 2011.
11. Yasuda J, Tsuchiya A, Yamada T, Sakamoto M, Sekiya T and Hirohashi S: Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. Biochem Biophys Res Commun 308: 227-233, 2003. (Pubitemid 36937170)
12. Emami KH, Brown LG, Pitts TE, Sun X, Vessella RL and Corey E: Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells. Prostate 69: 1481-1492, 2009.
13. Cui G, Li Z, Shao B, Zhao L, Zhou Y, Lu T, Wang J, Shi X, Wang J, Zuo G, Zhu W and Shen A: Clinical and biological significance of nemo-like kinase expression in glioma. J Clin Neurosci 18: 271-275, 2011.