Correlation between measures of hypoglycemia and glycemic improvement in sulfonylurea treated patients with type 2 diabetes in India: Results from the OBSTACLE hypoglycemia study

Journal of Postgraduate Medicine

Volumn 60, Issue 2, 2014, Pages 151-155

  Kalra, S ^a   Deepak, M C ^a,b   Narang, P ^a,c   Singh, V ^a,c   Maheshwari, A ^a,d  

^a India   (India)

^b Madhav Diabetes Center   (India)

^c Departments of Medical Affairs MSD Pharmaceuticals Pvt Ltd   (India)

^d Departments of Diabetes Sri Ramkamal Diabetes and Heart Clinic   (India)

Author keywords

HbA1c; hypoglycemia; Stanford hypoglycemia questionnaire; sulfonylurea; type 2 diabetes

Indexed keywords

GLIMEPIRIDE; HEMOGLOBIN A1C; METFORMIN; ORAL ANTIDIABETIC AGENT; SULFONYLUREA; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; SULFONYLUREA DERIVATIVE;

ADULT; AGED; ARTICLE; BODY MASS; CORRELATION ANALYSIS; DISEASE DURATION; FEMALE; FOLLOW UP; GLYCEMIC CONTROL; HUMAN; HYPOGLYCEMIA; INDIA; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; QUESTIONNAIRE; SCORING SYSTEM; STANFORD HYPOGLYCEMIA QUESTIONNAIRE; BLOOD; CHEMICALLY INDUCED; CLINICAL TRIAL; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PROSPECTIVE STUDY; REGRESSION ANALYSIS; TREATMENT FAILURE; TREATMENT OUTCOME;

ADULT; AGED; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INDIA; MALE; METFORMIN; MIDDLE AGED; PROSPECTIVE STUDIES; QUESTIONNAIRES; REGRESSION ANALYSIS; SULFONYLUREA COMPOUNDS; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 84901459439     PISSN: 00223859     EISSN: 09722823     Source Type: Journal    
DOI: 10.4103/0022-3859.132322     Document Type: Article

References (28)

1. Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352: 837-53.
2. Shichiri M, Kishikawa H, Ohkubo Y, Wake N. Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care 2000;23(Suppl 2): B21-9.
3. American Diabetes Association. Standards of medical care in diabetes-2013. Diabetes Care 2013;36(Suppl 1): S11-66.
4. Moses CR, Seshiah V, Sahay BK, Kumar A, Asirvatham AJ, Balaji V, et al. Baseline results indicate poor glycemic control and delay in initiation and optimization of insulin therapy: Results from the improving management practices and clinical outcomes in type 2 diabetes study. Indian J Endocrinol Metab 2012;16(Suppl 2): S432-3.
5. Mohan V, Seshiah V, Sahay BK, Shah SN, Rao PV, Banerjee S, et al. Current status of management of diabetes and glycaemic control in India: Preliminary results from the DiabCare India 2011 study. Diabetes 2012;61: A645-77.
6. Ahrn BO. Avoiding hypoglycemia: A key to success for glucoselowering therapy in type 2 diabetes. Vasc Health Risk Manag 2013;9: 155-63.
7. Amiel SA, Dixon T, Mann R, Jameson K. Hypoglycaemia in type 2 diabetes. Diabet Med 2008;25: 245-54.
8. Piette JD. Patient education via automated calls: A study of English and Spanish speakers with diabetes. Am J Prev Med 1999;17: 138-41.
9. Guidelines for Management of Type 2 Diabetes. Available from: Http://icmr.nic.in/guidelines-diabetes/section7.pdf. [Last accessed on 2012 May 28].
10. Sutharson L, Hariharan RS, Vamsadhara C. Drug utilization study in diabetology outpatient setting of a tertiary hospital. Indian J Pharmacol 2003;35: 237-40.
11. Sultana G, Kapur P, Aqil M, Alam MS, Pillai KK. Drug utilization of oral hypoglycemic agents in a university teaching hospital in India. J Clin Pharmacol Ther 2010;35: 267-77.
12. Ramesh R, Kumar SV, Gopinath S, Gavaskar B, Gandhiji G. Diabetic knowledge of rural community and drug utilization pattern in a tertiary care hospital. Int J Pharm Life Sci 2011;2: 531-5.
13. Abdi SA, Churi S, Kumar YS. Study of drug utilization pattern of antihyperglycemic agents in a South Indian tertiary care teaching hospital. Indian J Pharmacol 2012;44: 210-4.
14. Alvarez Guisasola F, Tof Povedano S, Krishnarajah G, Lyu R, Mavros P, Yin D. Hypoglycaemic symptoms, treatment satisfaction, adherence and their associations with glycaemic goal in patients with type 2 diabetes mellitus: Findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) Study. Diabetes Obes Metab 2008;10(Suppl 1): 25-32.
15. Miller CD, Phillips LS, Ziemer DC, Gallina DL, Cook CB, El Kebbi IM. Hypoglycemia in patients with type 2 diabetes mellitus. Arch Intern Med 2001;161: 1653-9.
16. Vexiau P, Mavros P, Krishnarajah G, Lyu R, Yin D. Hypoglycaemia in patients with type 2 diabetes treated with a combination of metformin and sulphonylurea therapy in France. Diabetes Obes Metab 2008;10(Suppl 1): 16-24.
17. Davis RE, Morrissey M, Peters JR, Wittrup-Jensen K, Kennedy-Martin T, Currie CJ. Impact of hypoglycaemia on quality of life and productivity in type 1 and type 2 diabetes. Curr Med Res Opin 2005;21: 1477-83.
18. Marrett E, Radican L, Davies MJ, Zhang Q. Assessment of severity and frequency of self-reported hypoglycemia on quality of life in patients with type 2 diabetes treated with oral anti-hyperglycemic agents: A survey study. BMC Res Notes 2011;4: 251.
19. Schopman JE, Simon AC, Hoefnagel SJ, Hoekstra JB, Scholten RJ, Holleman F. The incidence of mild and severe hypoglycaemia in patients with type 2 diabetes mellitus treated with sulfonylureas: A systematic review and meta-analysis. Diabetes Metab Res Rev 2014;30: 11-22.
20. Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, et al.; Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008;358: 2545-59.
21. Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, et al.; ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008;358: 2560-72.
22. Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009;360: 129-39.
23. Chan JY, Leyk M, Frier BM, Tan MH. Relationship between HbA1c and hypoglycaemia in patients with type 2 diabetes treated with different insulin regimens in combination with metformin. Diabetes Metab Res Rev 2009;25: 224-31.
24. Mullins P, Sharplin P, Yki-Jarvinen H, Riddle MC, Haring HU. Negative binomial meta-regression analysis of combined glycosylated hemoglobin and hypoglycemia outcomes across eleven Phase III and IV studies of insulin glargine compared with neutral protamine Hagedorn insulin in type 1 and type 2 diabetes mellitus. Clin Ther 2007;29: 1607-19.
25. Leiter LA, Yale J, Chiasson J, Harris SB, Kleinstever P, Sauriol L. Assessment of the impact of fear of hypoglycemic episodes on glycemic and hypoglycemia management. Can J Diabetes 2005;29: 186-92.
26. Petterson B, Rosenqvist U, Deleskog A, Journath G, Wndell P. Selfreported experience of hypoglycemia among adults with type 2 diabetes mellitus (Exhype). Diabetes Res Clin Pract 2011;92: 19-25.
27. Green AJ, Fox KM, Grandy S; SHIELD Study Group. Self-reported hypoglycemia and impact on quality of life and depression among adults with type 2 diabetes mellitus. Diabetes Res Clin Pract 2012;96: 313-8.
28. Viswanathan M, Joshi SR, Bhansali A. Hypoglycemia in type 2 diabetes: Standpoint of an experts committee (India hypoglycemia study group). Indian J Endocrinol Metab 2012;16: 894-8.