Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas

Blood

Volumn 123, Issue 21, 2014, Pages 3230-3238

  Graus, Francesc ^a,b   Ariño, Helena ^a,b   Dalmau, Josep ^a,c,d  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHOREA; DERMATOMYOSITIS; EATON LAMBERT SYNDROME; GRANULOMATOUS VASCULITIS; HODGKIN DISEASE; HUMAN; LYMPHOMA; LYMPHOMA CELL; MUSCLE; NEUROLOGIC DISEASE; NEUROMUSCULAR SYNAPSE; NONHODGKIN LYMPHOMA; OPSOCLONUS MYOCLONUS SYNDROME; PARANEOPLASTIC NEUROPATHY; PARANEOPLASTIC SYNDROME; PRIORITY JOURNAL; REVIEW; SENSORIMOTOR NEUROPATHY; SPINAL CORD DISEASE; STIFF MAN SYNDROME;

CENTRAL NERVOUS SYSTEM; HODGKIN DISEASE; HUMANS; LYMPHOMA, NON-HODGKIN; PARANEOPLASTIC SYNDROMES, NERVOUS SYSTEM; VASCULITIS, CENTRAL NERVOUS SYSTEM;

EID: 84901453124     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-03-537506     Document Type: Review

References (105)

1. Darnell RB, Posner JB. Paraneoplastic Syndromes. Contemporary Neurology Series 79. Oxford, UK: Oxford University Press; 2011: 1-482.
2. Graus F, Delattre JY, Antoine JC, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry. 2004;75(8):1135-1140. (Pubitemid 39005770)
3. Sabater L, Titulaer M, Saiz A, Verschuuren J, Güre AO, Graus F. SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome. Neurology. 2008;70(12):924-928. (Pubitemid 351430756)
4. Sabater L, Höftberger R, Boronat A, Saiz A, Dalmau J, Graus F. Antibody repertoire in paraneoplastic cerebellar degeneration and small cell lung cancer. PLoS ONE. 2013;8(3): e60438.
5. Bernal F, Shams'ili S, Rojas I, et al. Anti-Tr antibodies as markers of paraneoplastic cerebellar degeneration and Hodgkin's disease. Neurology. 2003;60(2):230-234. (Pubitemid 36152014)
6. de Graaff E, Maat P, Hulsenboom E, et al. Identification of delta/notch-like epidermal growth factor-related receptor as the Tr antigen in paraneoplastic cerebellar degeneration. Ann Neurol. 2012;71(6):815-824.
7. Lancaster E, Dalmau J. Neuronal autoantigens-pathogenesis, associated disorders and antibody testing. Nat Rev Neurol. 2012;8(7):380-390.
8. Titulaer MJ, McCracken L, Gabilondo I, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol. 2013;12(2):157-165.
9. Lai M, Huijbers MG, Lancaster E, et al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol. 2010; 9(8):776-785.
10. Titulaer MJ, Maddison P, Sont JK, et al. Clinical Dutch-English Lambert-Eaton Myasthenic syndrome (LEMS) tumor association prediction score accurately predicts small-cell lung cancer in the LEMS. J Clin Oncol. 2011;29(7):902-908.
11. Lancaster E, Lai M, Peng X, et al. Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol. 2010;9(1):67-76.
12. Irani SR, Pettingill P, Kleopa KA, et al. Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol. 2012;72(2):241-255.
13. Lai M, Hughes EG, Peng X, et al. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol. 2009;65(4): 424-434.
14. Boronat A, Gelfand JM, Gresa-Arribas N, et al. Encephalitis and antibodies to dipeptidylpeptidase- like protein-6, a subunit of Kv4.2 potassium channels. Ann Neurol. 2013;73(1): 120-128.
15. Sillevis Smitt P, Kinoshita A, De Leeuw B, et al. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. N Engl J Med. 2000;342(1):21-27. (Pubitemid 30020656)
16. Lancaster E, Martinez-Hernandez E, Titulaer MJ, et al. Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome. Neurology. 2011;77(18):1698-1701.
17. Briani C, Vitaliani R, Grisold W, et al; PNS Euronetwork. Spectrum of paraneoplastic disease associated with lymphoma. Neurology. 2011;76(8):705-710.
18. Gultekin SH, Rosenfeld MR, Voltz R, Eichen J, Posner JB, Dalmau J. Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain. 2000;123(Pt 7):1481-1494. (Pubitemid 30420947)
19. Carr I. The Ophelia syndrome: memory loss in Hodgkin's disease. Lancet. 1982;1(8276): 844-845. (Pubitemid 12133667)
20. Duyckaerts C, Derouesne C, Signoret JL, Gray F, Escourolle R, Castaigne P. Bilateral and limited amygdalohippocampal lesions causing a pure amnesic syndrome. Ann Neurol. 1985; 18(3):314-319. (Pubitemid 15023104)
21. Deodhare S, O'Connor P, Ghazarian D, Bilbao JM. Paraneoplastic limbic encephalitis in Hodgkin's disease. Can J Neurol Sci. 1996; 23(2):138-140. (Pubitemid 26186483)
22. Rosenbaum T, Gärtner J, Körholz D, et al. Paraneoplastic limbic encephalitis in two teenage girls. Neuropediatrics. 1998;29(3): 159-162. (Pubitemid 28327885)
23. Kung S, Mueller PS, Geda YE, Krahn LE. Delirium resulting from paraneoplastic limbic encephalitis caused by Hodgkin's disease. Psychosomatics. 2002;43(6):498-501. (Pubitemid 35286059)
24. Pfliegler G, Pósán E, Glaub D, Telek B, Rak K. Hodgkin's disease and memory loss: another case of the Ophelia syndrome. Br J Haematol. 1990;74(2):232. (Pubitemid 20041101)
25. Shinohara T, Kojima H, Nakamura N, et al. Pathology of pure hippocampal sclerosis in a patient with dementia and Hodgkin's disease: the Ophelia syndrome. Neuropathology. 2005; 25(4):353-360. (Pubitemid 43943245)
26. Olmos D, Rueda A, Jurado JM, Alba E. Presentation of Hodgkin's lymphoma with Ophelia syndrome. J Clin Oncol. 2007;25(13): 1802-1803. (Pubitemid 46797964)
27. Hentschke S, Malzfeldt E, Salwender HJ, Braumann D, Stang A, Hentschke M. Huantibody positive limbic encephalitis in a patient with Hodgkin lymphoma. Leuk Lymphoma. 2008; 49(12):2374-2376.
28. Zandi MS, Irani SR, Follows G, Moody AM, Molyneux P, Vincent A. Limbic encephalitis associated with antibodies to the NMDA receptor in Hodgkin lymphoma. Neurology. 2009;73(23): 2039-2040.
29. Laffon M, Giordana C, Almairac F, Benchetrit M, Thomas P. Anti-Hu-associated paraneoplastic limbic encephalitis in Hodgkin lymphoma. Leuk Lymphoma. 2012;53(7):1433-1434.
30. Mat A, Adler H, Merwick A, et al. Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF. Neurology. 2013;80(14): 1349-1350.
31. Bernard P, Vinzio S, Talarmin F, Kadouri A, Flocard F. [Hodgkin's disease manifesting as paraneoplastic limbic encephalitis]. Rev Med Interne. 2003;24(4):257-260. (Pubitemid 36542170)
32. Epaulard O, Courby S, Pavese P, et al. Paraneoplastic acute diffuse encephalitis revealing Hodgkin's disease. Leuk Lymphoma. 2004;45(12):2509-2512. (Pubitemid 40081199)
33. Mollier-Saliner J, Thouvenin S, Darteyre S, et al. [Paraneoplastic limbic encephalitis: 2 pediatric cases]. Arch Pediatr. 2013;20(4):386-390.
34. Mihara M, Sugase S, Konaka K, et al. The "pulvinar sign" in a case of paraneoplastic limbic encephalitis associated with non-Hodgkin's lymphoma. J Neurol Neurosurg Psychiatry. 2005;76(6):882-884. (Pubitemid 40805826)
35. Dögel D, Beuing O, Koenigsmann M, Diete S. [Paraneoplastic limbic encephalitis resulting from non-Hodgkin-lymphoma: two case reports]. Fortschr Neurol Psychiatr. 2008;76(1):41-46. (Pubitemid 351251230)
36. Rajappa S, Digumarti R, Immaneni SR, Parage M. Primary renal lymphoma presenting with paraneoplastic limbic encephalitis. J Clin Oncol. 2007;25(24):3783-3785. (Pubitemid 47372622)
37. Markert A, May A, Weber J, Rottenburger C, Rauer S, Veelken H. Bilateral renal lymphoma after paraneoplastic limbic encephalitis. J Clin Oncol. 2009;27(7):1142-1144.
38. Thuerl C, Müller K, Laubenberger J, Volk B, Langer M. MR imaging of autopsy-proved paraneoplastic limbic encephalitis in non- Hodgkin lymphoma. AJNR Am J Neuroradiol. 2003;24(3):507-511. (Pubitemid 36359007)
39. Seeley WW, Marty FM, Holmes TM, et al. Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. Neurology. 2007;69(2):156-165. (Pubitemid 47051720)
40. Hajj-Ali RA, Singhal AB, Benseler S, Molloy E, Calabrese LH. Primary angiitis of the CNS. Lancet Neurol. 2011;10(6):561-572.
41. Delobel P, Brassat D, Danjoux M, et al. Granulomatous angiitis of the central nervous system revealing Hodgkin's disease. J Neurol. 2004;251(5):611-612. (Pubitemid 38680308)
42. Rosen CL, DePalma L, Morita A. Primary angiitis of the central nervous system as a first presentation in Hodgkin's disease: a case report and review of the literature. Neurosurgery. 2000; 46(6):1504-1508, discussion 1508-1510.
43. Sheehy N, Sheehan K, Brett F, Kay E, Grogan L, Delanty N. Hodgkins disease presenting with granulomatous angiitis of the central nervous system. J Neurol. 2003;250(1):112-113. (Pubitemid 36206699)
44. Power DG, Mullholland PJ, Sheehy N, Farrell MA, Daly PA. Relapsing granulomatous angiitis of the central nervous system in a patient while in remission from Hodgkin lymphoma. Ir Med J. 2006;99(9):282.
45. Fuehrer NE, Hammack JE, Morris JM, Kaufmann TJ, Giannini C. Teaching NeuroImages: granulomatous angiitis of the CNS associated with Hodgkin lymphoma. Neurology. 2011;77(19):e110-e111.
46. Le Guennec L, Roos-Weil D, Mokhtari K, et al. Granulomatous angiitis of the CNS revealing a Hodgkin lymphoma. Neurology. 2013;80(3): 323-324.
47. Shams'ili S, Grefkens J, de Leeuw B, et al. Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients. Brain. 2003;126(Pt 6):1409-1418. (Pubitemid 36644385)
48. Ang LC, Zochodne DW, Ebers GC, Kaufmann JC, Vinters HV. Severe cerebellar degeneration in a patient with T-cell lymphoma. Acta Neuropathol. 1986;69(1-2):171-175. (Pubitemid 16146268)
49. Rodis DG, Liatsos GD, Moulakakis A, Pirounaki M, Tasidou A. Paraneoplastic cerebellar degeneration: initial presentation in a patient with anaplastic T-cell lymphoma, associated with ichthyosiform cutaneous lesions. Leuk Lymphoma. 2009;50(8):1369-1371.
50. Shimazu Y, Minakawa EN, Nishikori M, et al. A case of follicular lymphoma associated with paraneoplastic cerebellar degeneration. Intern Med. 2012;51(11):1387-1392.
51. Trotter JL, Hendin BA, Osterland CK. Cerebellar degeneration with Hodgkin disease. An immunological study. Arch Neurol. 1976;33(9): 660-661.
52. Graus F, Dalmau J, Valldeoriola F, et al. Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease. J Neuroimmunol. 1997;74(1-2):55-61. (Pubitemid 27128977)
53. Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M. Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. J Biol Chem. 2002;277(28): 25400-25407. (Pubitemid 34951852)
54. Sillevis Smitt P, Kinoshita A, De Leeuw B, et al. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. N Engl J Med. 2000;342(1):21-27. (Pubitemid 30020656)
55. Marignier R, Chenevier F, Rogemond V, et al. Metabotropic glutamate receptor type 1 autoantibody-associated cerebellitis: a primary autoimmune disease? Arch Neurol. 2010;67(5): 627-630.
56. Hammack JE, Kotanides H, Rosenblum MK, Posner JB. Paraneoplastic cerebellar degeneration. II. Clinical and immunologic findings in 21 patients with Hodgkin's disease. Neurology. 1992;42(10):1938-1943.
57. Vigliani MC, Honnorat J, Antoine JC, et al; PNS EuroNetwork. Chorea and related movement disorders of paraneoplastic origin: the PNS EuroNetwork experience. J Neurol. 2011; 258(11):2058-2068.
58. O'Toole O, Lennon VA, Ahlskog JE, et al. Autoimmune chorea in adults. Neurology. 2013; 80(12):1133-1144.
59. Batchelor TT, Platten M, Palmer-Toy DE, et al. Chorea as a paraneoplastic complication of Hodgkin's disease. J Neurooncol. 1998;36(2): 185-190. (Pubitemid 28073675)
60. Vernino S, Tuite P, Adler CH, et al. Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma. Ann Neurol. 2002;51(5):625-630.
61. Caviness JN, Forsyth PA, Layton DD, McPhee TJ. The movement disorder of adult opsoclonus. Mov Disord. 1995;10(1):22-27.
62. Bataller L, Graus F, Saiz A, Vilchez JJ; Spanish Opsoclonus-Myoclonus Study Group. Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus-myoclonus. Brain. 2001;124(Pt 2):437-443. (Pubitemid 32142415)
63. Ducrocq X, Petit J, Taillandier L, et al. [Paraneoplastic opsoclonus-myoclonus syndrome revealing T-cell lymphoma]. Presse Med. 1999;28(7):330-333. (Pubitemid 29100526)
64. Kumar A, Lajara-Nanson WA, Neilson RW Jr. Paraneoplastic Opsoclonus-Myoclonus Syndrome: initial presentation of non-Hodgkins lymphoma. J Neurooncol. 2005;73(1):43-45. (Pubitemid 40823265)
65. Gabaldon-Torres L, Fernandez-Dominguez J, Salas-Felipe J, et al. [Opsoclonus-myoclonusataxia syndrome: two anatomo-clinical case reports]. Rev Neurol. 2009;48(3):137-140.
66. Kay CL, Davies-Jones GA, Singal R, Winfield DA. Paraneoplastic opsoclonus-myoclonus in Hodgkin's disease. J Neurol Neurosurg Psychiatry. 1993;56(7):831-832.
67. McKeon A, Robinson MT, McEvoy KM, et al. Stiff-man syndrome and variants: clinical course, treatments, and outcomes. Arch Neurol. 2012; 69(2):230-238.
68. Whiteley AM, Swash M, Urich H. Progressive encephalomyelitis with rigidity. Brain. 1976; 99(1):27-42.
69. McKeon A, Martinez-Hernandez E, Lancaster E, et al. Glycine receptor autoimmune spectrum with stiff-man syndrome phenotype. JAMA Neurol. 2013;70(1):44-50.
70. Ferrari P, Federico M, Grimaldi LM, Silingardi V. Stiff-man syndrome in a patient with Hodgkin's disease. An unusual paraneoplastic syndrome. Haematologica. 1990;75(6):570-572.
71. Gutmann B, Crivellaro C, Mitterer M, Zingerle H, Egarter-Vigl E, Wiedermann CJ. Paraneoplastic stiff-person syndrome, heterotopic soft tissue ossification and gonarthritis in a HLA B27- positive woman preceding the diagnosis of Hodgkin's lymphoma. Haematologica. 2006; 91(12 Suppl):ECR59.
72. Schmidt C, Freilinger T, Lieb M, et al. Progressive encephalomyelitis with rigidity and myoclonus preceding otherwise asymptomatic Hodgkin's lymphoma. J Neurol Sci. 2010; 291(1-2):118-120.
73. Flanagan EP, McKeon A, Lennon VA, et al. Paraneoplastic isolated myelopathy: clinical course and neuroimaging clues. Neurology. 2011;76(24):2089-2095.
74. Ojeda VJ. Necrotizing myelopathy associated with malignancy. A clinicopathologic study of two cases and literature review. Cancer. 1984;53(5): 1115-1123.
75. Gray F, Hauw JJ, Escourolle R, Castaigne P. [Necrotic myelopathies and neoplastic pathologie. Three clinico-pathological cases (author's transl)]. Rev Neurol (Paris). 1980; 136(3):235-246. (Pubitemid 10058973)
76. Hughes M, Ahern V, Kefford R, Boyages J. Paraneoplastic myelopathy at diagnosis in a patient with pathologic stage 1A Hodgkin disease. Cancer. 1992;70(6):1598-1600.
77. Anderson DW, Borsaru A. Case report: Lymphoma-related resolving paraneoplastic myelopathy with MRI correlation. Br J Radiol. 2008;81(964):e103-e105.
78. Graus F, Keime-Guibert F, Reñe R, et al. Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain. 2001;124(Pt 6):1138-1148. (Pubitemid 32510382)
79. Schold SC, Cho ES, Somasundaram M, Posner JB. Subacute motor neuronopathy: a remote effect of lymphoma. Ann Neurol. 1979;5(3): 271-287. (Pubitemid 9135415)
80. Flanagan EP, Sandroni P, Pittock SJ, Inwards DJ, Jones LK Jr. Paraneoplastic lower motor neuronopathy associated with Hodgkin lymphoma. Muscle Nerve. 2012;46(5):823-827.
81. Horwich MS, Cho L, Porro RS, Posner JB. Subacute sensory neuropathy: a remote effect of carcinoma. Ann Neurol. 1977;2(1):7-19.
82. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 8-1990. A 45-year-old woman with Hodgkin's disease and a neurologic disorder. N Engl J Med. 1990;322(8):531-543.
83. Maslovsky I, Volchek L, Blumental R, Ducach A, Lugassy G. Persistent paraneoplastic neurologic syndrome after successful therapy of Hodgkin's disease. Eur J Haematol. 2001;66(1):63-65. (Pubitemid 32099412)
84. Oh BC, Lim YM, Kwon YM, Khang SK, Kim KK. A case of Hodgkin's lymphoma associated with sensory neuropathy. J Korean Med Sci. 2004; 19(1):130-133. (Pubitemid 38296289)
85. Plante-Bordeneuve V, Baudrimont M, Gorin NC, Gherardi RK. Subacute sensory neuropathy associated with Hodgkin's disease. J Neurol Sci. 1994;121(2):155-158. (Pubitemid 24044880)
86. Koike H, Watanabe H, Sobue G. The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features. J Neurol Neurosurg Psychiatry. 2013;84(1): 98-106.
87. van Lieshout JJ, Wieling W, van Montfrans GA, et al. Acute dysautonomia associated with Hodgkin's disease. J Neurol Neurosurg Psychiatry. 1986;49(7):830-832. (Pubitemid 16100424)
88. Hollenbeck R, Black BK, Peltier AC, et al. Longterm treatment with rituximab of autoimmune autonomic ganglionopathy in a patient with lymphoma. Arch Neurol. 2011;68(3):372-375.
89. Horta E, McKeon A, Lennon VA, Benarroch EE. Reversible paraneoplastic tonic pupil with PCA-Tr IgG and Hodgkin lymphoma. Neurology. 2012;78(20):1620-1622.
90. Shepshelovich D, Shpilberg O, Lahav M, et al. Hodgkin lymphoma and hypothermia: Case report and review of the literature. Acta Haematol. 2013;131(4):227-230.
91. Vallat JM, De Mascarel HA, Bordessoule D, et al. Non-Hodgkin malignant lymphomas and peripheral neuropathies-13 cases. Brain. 1995; 118(Pt 5):1233-1245.
92. Lisak RP, Mitchell M, Zweiman B, Orrechio E, Asbury AK. Guillain-Barré syndrome and Hodgkin's disease: three cases with immunological studies. Ann Neurol. 1977;1(1): 72-78.
93. Kobayashi M, Kato K, Funakoshi K, Watanabe S, Toyoshima I. Neuropathology of paraneoplastic neuropathy with anti-disialosyl antibody. Muscle Nerve. 2005;32(2):216-222. (Pubitemid 41061495)
94. Tomita M, Koike H, Kawagashira Y, et al. Clinicopathological features of neuropathy associated with lymphoma. Brain. 2013; 136(Pt 8):2563-2578.
95. Baehring JM, Batchelor TT. Diagnosis and management of neurolymphomatosis. Cancer J. 2012;18(5):463-468.
96. Oh SJ. Paraneoplastic vasculitis of the peripheral nervous system. Neurol Clin. 1997; 15(4):849-863. (Pubitemid 28009352)
97. Zivkovíc SA, Ascherman D, Lacomis D. Vasculitic neuropathy-electrodiagnostic findings and association with malignancies. Acta Neurol Scand. 2007;115(6):432-436. (Pubitemid 46776320)
98. Vincent D, Gombert B, Vital A, Vital C. A case of mononeuropathy multiplex with type II cryoglobulinemia, necrotizing vasculitis and low grade B cell lymphoma. Clin Neuropathol. 2007; 26(1):28-31. (Pubitemid 46145389)
99. Marie I, Guillevin L, Menard JF, et al. Hematological malignancy associated with polymyositis and dermatomyositis. Autoimmun Rev. 2012;11(9):615-620.
100. Selva-O'Callaghan A, Trallero-Araguás E, Grau-Junyent JM, Labrador-Horrillo M. Malignancy and myositis: novel autoantibodies and new insights. Curr Opin Rheumatol. 2010; 22(6):627-632.
101. Trallero-Araguás E, Rodrigo-Pendás JÁ, Selva- O'Callaghan A, et al. Usefulness of anti-p155 autoantibody for diagnosing cancer-associated dermatomyositis: a systematic review and metaanalysis. Arthritis Rheum. 2012;64(2):523-532.
102. Argov Z, Shapira Y, Averbuch-Heller L, Wirguin I. Lambert-Eaton myasthenic syndrome (LEMS) in association with lymphoproliferative disorders. Muscle Nerve. 1995;18(7):715-719.
103. Caress JB, Abend WK, Preston DC, Logigian EL. A case of Hodgkin's lymphoma producing neuromyotonia. Neurology. 1997;49(1):258-259. (Pubitemid 27328713)
104. Rana SS, Ramanathan RS, Small G, Adamovich B. Paraneoplastic Isaacs' syndrome: a case series and review of the literature. J Clin Neuromuscul Dis. 2012;13(4):228-233.
105. Rezania K, Soliven B, Baron J, Lin H, Penumalli V, van Besien K. Myasthenia gravis, an autoimmune manifestation of lymphoma and lymphoproliferative disorders: case reports and review of literature. Leuk Lymphoma. 2012; 53(3):371-380.