Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress

FEBS Letters

Volumn 588, Issue 12, 2014, Pages 2115-2124

  Li, Wenjuan ^a   Wu, Weiwei ^a   Song, Haibo ^a   Wang, Fang ^a   Li, Huanjie ^a   Chen, Li ^a,b   Lai, Yimu ^b   Janicki, Joseph S ^a   Ward, Keith W ^c   Meyer, Colin J ^c   Wang, Xing Li ^a   Tang, Dongqi ^a,b   Cui, Taixing ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c Reata Pharmaceuticals Inc   (United States)

Author keywords

Autophagy; Diabetes; Nrf2; Oxidative stress; Ubiquitination; Cells

Indexed keywords

ANTIDIABETIC AGENT; DIHYDRO BARDOXOLONE TRIFLUOROETHYL AMIDE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; AUTOLYSOSOME; AUTOPHAGY; CELL VIABILITY; CLEARANCE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; FEMALE; GENE INDUCTION; GENETIC CONSERVATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; INSULIN RESISTANCE; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RAT; UBIQUITINATION;

MUS; RATTUS; RODENTIA;

AUTOPHAGY; DIABETES; NRF2; OXIDATIVE STRESS; UBIQUITINATION; Β-CELLS;

ANIMALS; AUTOPHAGY; CELL SURVIVAL; HUMANS; HYDROGEN PEROXIDE; INSULIN-SECRETING CELLS; MALE; MICE; MIDDLE AGED; NF-E2-RELATED FACTOR 2; OLEANOLIC ACID; OXIDATIVE STRESS; RATS; UBIQUITINATION;

EID: 84901428607     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.04.046     Document Type: Article

References (31)

1. P. Zimmet, K.G. Alberti, and J. Shaw Global and societal implications of the diabetes epidemic Nature 414 2001 782 787 (Pubitemid 34000780)
2. C.J. Rhodes Type 2 diabetes-a matter of beta-cell life and death? Science 307 2005 380 384 (Pubitemid 40139973)
3. R.P. Robertson Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes J. Biol. Chem. 279 2004 42351 42354
4. R.P. Robertson, J. Harmon, P.O. Tran, and V. Poitout Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes Diabetes 53 Suppl. 1 2004 S119 S124 (Pubitemid 38168703)
5. D.V. Chartoumpekis, and T.W. Kensler New player on an old field; the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome Curr. Diabetes Rev. 9 2013 137 145
6. J. Xu, S.R. Kulkarni, A.C. Donepudi, V.R. More, and A.L. Slitt Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice Diabetes 61 2012 3208 3218
7. A. Uruno et al. The Keap1-Nrf2 system prevents onset of diabetes mellitus Mol. Cell. Biol. 33 2013 2996 3010
8. S. Pugazhenthi, L. Akhov, G. Selvaraj, M. Wang, and J. Alam Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells Am. J. Physiol. Endocrinol. Metab. 293 2007 E645 E655
9. M.Y. Song et al. Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway Toxicol. Appl. Pharmacol. 235 2009 57 67
10. B. Yang et al. Deficiency in the nuclear factor E2-related factor 2 renders pancreatic beta-cells vulnerable to arsenic-induced cell damage Toxicol. Appl. Pharmacol. 264 2012 315 323
11. X. Wang et al. Protective effect of oleanolic acid against beta cell dysfunction and mitochondrial apoptosis: crucial role of ERK-NRF2 signaling pathway J. Biol. Regul. Homeost. Agents 27 2013 55 67
12. Y. Yagishita, T. Fukutomi, A. Sugawara, H. Kawamura, T. Takahashi, J. Pi, A. Uruno, and M. Yamamoto Nrf2 protects pancreatic beta-cells from oxidative and nitrosative stress in diabetic model mice Diabetes 63 2014 605 618
13. N.A. Kaniuk, M. Kiraly, H. Bates, M. Vranic, A. Volchuk, and J.H. Brumell Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy Diabetes 56 2007 930 939 (Pubitemid 46525060)
14. C. Ebato et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet Cell Metab. 8 2008 325 332
15. N. Mizushima, T. Yoshimori, and B. Levine Methods in mammalian autophagy research Cell 140 2010 313 326
16. K. Fujita, D. Maeda, Q. Xiao, and S.M. Srinivasula Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation Proc. Natl. Acad. Sci. U.S.A. 108 2011 1427 1432
17. J. Li, T. Ichikawa, J.S. Janicki, and T. Cui Targeting the Nrf2 pathway against cardiovascular disease Expert Opin. Ther. Targets 13 2009 785 794
18. N. Gurusamy, and D.K. Das Autophagy, redox signaling, and ventricular remodeling Antioxid. Redox Signal. 11 2009 1975 1988
19. R. Nishimura et al. Tacrolimus inhibits the revascularization of isolated pancreatic islets PLoS One 8 2013 e56799
20. N. Lembert, J. Wesche, P. Petersen, M. Doser, H.D. Becker, and H.P. Ammon Areal density measurement is a convenient method for the determination of porcine islet equivalents without counting and sizing individual islets Cell Transplant. 12 2003 33 41 (Pubitemid 36397313)
21. T. Ichikawa, J. Li, C.J. Meyer, J.S. Janicki, M. Hannink, and T. Cui Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes PLoS One 4 2009 e8391
22. B. Gier, P. Krippeit-Drews, T. Sheiko, L. Aguilar-Bryan, J. Bryan, M. Dufer, and G. Drews Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress J. Clin. Invest. 119 2009 3246 3256
23. G. Matsumoto, K. Wada, M. Okuno, M. Kurosawa, and N. Nukina Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins Mol. Cell 44 2011 279 289
24. D.C. Rubinsztein The roles of intracellular protein-degradation pathways in neurodegeneration Nature 443 2006 780 786 (Pubitemid 44622682)
25. E. Wong, and A.M. Cuervo Integration of clearance mechanisms: the proteasome and autophagy Cold Spring Harb. Perspect. Biol. 2 2010 a006734
26. M.N. Moore Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress Autophagy 4 2008 254 256 (Pubitemid 351231195)
27. G. Filomeni, E. Desideri, S. Cardaci, G. Rotilio, and M.R. Ciriolo Under the ROS...thiol network is the principal suspect for autophagy commitment Autophagy 6 2010 999 1005
28. M. Chin, C.Y. Lee, J.C. Chuang, R. Bumeister, W.C. Wigley, S.T. Sonis, K.W. Ward, and C. Meyer Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity Am. J. Physiol. Renal Physiol. 304 2013 F1438 F1446
29. R. Ahmad, D. Raina, C. Meyer, S. Kharbanda, and D. Kufe Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179 J. Biol. Chem. 281 2006 35764 35769 (Pubitemid 46041307)
30. R. Ahmad, D. Raina, C. Meyer, and D. Kufe Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1) - >signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3 Cancer Res. 68 2008 2920 2926 (Pubitemid 351556292)
31. Y. Wang et al. A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9- dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma Mol. Endocrinol. 14 2000 1550 1556