Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice

Journal of Biological Chemistry

Volumn 289, Issue 21, 2014, Pages 15104-15117

  Paik, Jisun ^a   Haenisch, Michael ^a   Muller, Charles H ^a   Goldstein, Alex S ^a   Arnold, Samuel ^a   Isoherranen, Nina ^a   Brabb, Thea ^a   Treuting, Piper M ^a   Amory, John K ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Focused Scientific   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; ESTERIFICATION; ESTERS; METABOLISM; NUTRITION; PHYSIOLOGY; TISSUE;

IN-VITRO; IN-VIVO; RETINOIC ACIDS; RETINYL ESTER;

MAMMALS;

FERTILYSIN; ORAL CONTRACEPTIVE AGENT; PROTEIN ALDH1A2; RETINAL DEHYDROGENASE; RETINOIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER; LUNG; MALE; METABOLIC INHIBITION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RETINOL DEFICIENCY; SPERMATOGENESIS; TISSUE DISTRIBUTION; VITAMIN BLOOD LEVEL; VITAMIN METABOLISM;

ADIPOSE TISSUE; ALDH1A2; ANIMAL MODELS; BISDICHLOROACETYLDIAMINE; FERTILITY; METABOLISM; OBESITY; RETINOIC ACID; VITAMIN A;

ADIPOSE TISSUE; ANIMALS; BIOCATALYSIS; DIAMINES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESTERS; HUMANS; LIVER; LUNG; MALE; MICE; MICE, INBRED C57BL; RETINAL DEHYDROGENASE; RETINOIDS; SPERMATOCYTES; SPERMATOGENESIS; TESTIS; TRETINOIN; VITAMIN A; WEIGHT GAIN;

EID: 84901418405     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.540211     Document Type: Article

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