Automated quantification of MART1-verified Ki-67 indices: Useful diagnostic aid in melanocytic lesions

Human Pathology

Volumn 45, Issue 6, 2014, Pages 1153-1161

  Nielsen, Patricia Switten ^a   Spaun, Eva ^a   Riber Hansen, Rikke ^a   Torben, Steiniche ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Computer assisted image analysis; Diagnosis; Immunohistochemical double staining; Ki 67; Melanocytic lesions; Melanoma; Proliferation index

Indexed keywords

KI 67 ANTIGEN; MELAN A;

ADULT; ARTICLE; BLUE NEVUS; CUTANEOUS MELANOMA; DERMIS; DYSPLASTIC NEVUS; EPIDERMIS; FEMALE; HALO NEVUS; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; JUVENILE MELANOMA; LENTIGO; MAJOR CLINICAL STUDY; MALE; MALIGNANT LENTIGO; MELANOCYTIC NEVUS; MELANOMA; NEVUS; RECEIVER OPERATING CHARACTERISTIC; SENTINEL LYMPH NODE;

COMPUTER-ASSISTED IMAGE ANALYSIS; DIAGNOSIS; IMMUNOHISTOCHEMICAL DOUBLE STAINING; KI-67; MELANOCYTIC LESIONS; MELANOMA; PROLIFERATION INDEX;

AREA UNDER CURVE; AUTOMATION; CARCINOMA IN SITU; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MART-1 ANTIGEN; MELANOMA; MIDDLE AGED; MITOTIC INDEX; NEVUS, PIGMENTED; ROC CURVE; SENTINEL LYMPH NODE BIOPSY; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84901418397     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2014.01.009     Document Type: Article

References (34)

1. S.W. McCarthy, and R.A. Scolyer Melanocytic lesions of the face: diagnostic pitfalls Ann Acad Med Singapore 33 2004 3 14
2. T. Brenn Pitfalls in the evaluation of melanocytic lesions Histopathology 60 2012 690 705
3. M.J. Kornstein, and S.P. Byrne The medicolegal aspect of error in pathology: a search of jury verdicts and settlements Arch Pathol Lab Med 131 2007 615 618
4. D. Ivan, and V.G. Prieto Use of immunohistochemistry in the diagnosis of melanocytic lesions: applications and pitfalls Future Oncol 6 2010 1163 1175
5. K. Glatz, C. Hartmann, M. Antic, and H. Kutzner Frequent mitotic activity in banal melanocytic nevi uncovered by immunohistochemical analysis Am J Dermatopathol 32 2010 643 649
6. P.S. Nielsen, R. Riber-Hansen, and T. Steiniche Immunohistochemical double stains against Ki67/MART1 and HMB45/MITF: promising diagnostic tools in melanocytic lesions Am J Dermatopathol 33 2011 361 370
7. R.G. Ladstein, I.M. Bachmann, O. Straume, and L.A. Akslen Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma BMC Cancer 10 2010 140
8. H.P. Soyer Ki 67 immunostaining in melanocytic skin tumors. Correlation with histologic parameters J Cutan Pathol 18 1991 264 272
9. P.K. Puri, C.L. Valdes, J.L. Burchette, J.M. Grichnik, J.W. Turner, and M.A. Selim Accurate identification of proliferative index in melanocytic neoplasms with Melan-A/Ki-67 double stain J Cutan Pathol 37 2010 1010 1012
10. P.S. Nielsen, R. Riber-Hansen, J. Raundahl, and T. Steiniche Automated quantification of MART1-verified Ki67 indices by digital image analysis in melanocytic lesions Arch Pathol Lab Med 136 2012 627 634
11. L.X. Li, K.A. Crotty, S.W. McCarthy, A.A. Palmer, and J.J. Kril A zonal comparison of MIB1-Ki67 immunoreactivity in benign and malignant melanocytic lesions Am J Dermatopathol 22 2000 489 495
12. B. Lebe, U. Pabuccuoglu, and E. Ozer The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions Appl Immunohistochem Mol Morphol 15 2007 160 164
13. P. Kapur, M.A. Selim, L.C. Roy, M. Yegappan, A.G. Weinberg, and M.P. Hoang Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis Mod Pathol 18 2005 197 204
14. J.A. Chorny, R.J. Barr, A. Kyshtoobayeva, J. Jakowatz, and R.J. Reed Ki-67 and p53 expression in minimal deviation melanomas as compared with other nevomelanocytic lesions Mod Pathol 16 2003 525 529
15. R. Bergman, L. Malkin, E. Sabo, and H. Kerner MIB-1 monoclonal antibody to determine proliferative activity of Ki-67 antigen as an adjunct to the histopathologic differential diagnosis of Spitz nevi J Am Acad Dermatol 44 2001 500 504
16. P. Rudolph, C. Schubert, B. Schubert, and R. Parwaresch Proliferation marker Ki-S5 as a diagnostic tool in melanocytic lesions J Am Acad Dermatol 37 1997 169 178
17. C. Stefanaki, K. Stefanaki, and C. Antoniou et al. Cell cycle and apoptosis regulators in Spitz nevi: comparison with melanomas and common nevi J Am Acad Dermatol 56 2007 815 824
18. M.R. Nasr, and O. El-Zammar Comparison of pHH3, Ki-67, and survivin immunoreactivity in benign and malignant melanocytic lesions Am J Dermatopathol 30 2008 117 122
19. P.E. LeBoit, G. Burg, D. Weedon, and A. Sarasin World Health Organization classification of tumours. Pathology and genetics of skin tumours 2006 IARC Press Lyon, France
20. G. Massi, and P.E. Boit Histological diagnosis of nevi and melanoma 2004 Steinkopff Verlag Darmstadt Würtzburg, Germany p. 227-8
21. P.S. Nielsen, R. Riber-Hansen, T.O. Jensen, H. Schmidt, and T. Steiniche Proliferation indices of phosphohistone H3 and Ki67: strong prognostic markers in a consecutive cohort with stage I/II melanoma Mod Pathol 26 2013 404 413
22. D.L. Morton, J.F. Thompson, and A.J. Cochran et al. Sentinel-node biopsy or nodal observation in melanoma N Engl J Med 355 2006 1307 1317
23. J.F. Thompson, and H.M. Shaw Should tumor mitotic rate and patient age, as well as tumor thickness, be used to select melanoma patients for sentinel node biopsy? Ann Surg Oncol 11 2004 233 235
24. C.M. Balch, J.E. Gershenwald, and S.J. Soong et al. Final version of 2009 AJCC melanoma staging and classification J Clin Oncol 27 2009 6199 6206
25. B.E. Gould Rothberg, M.B. Bracken, and D.L. Rimm Tissue biomarkers for prognosis in cutaneous melanoma: a systematic review and meta-analysis J Natl Cancer Inst 101 2009 452 474
26. T. Hasegawa Histological grading and MIB-1 labeling index of soft-tissue sarcomas Pathol Int 57 2007 121 125
27. A. Goldhirsch, J.N. Ingle, and R.D. Gelber et al. Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009 Ann Oncol 20 2009 1319 1329
28. A. Vaisanen, P. Kuvaja, M. Kallioinen, and T. Turpeenniemi-Hujanen A prognostic index in skin melanoma through the combination of matrix metalloproteinase-2, Ki67, and p53 Hum Pathol 42 2011 1103 1111
29. P.A. Gimotty, P. Van Belle, and D.E. Elder et al. Biologic and prognostic significance of dermal Ki67 expression, mitoses, and tumorigenicity in thin invasive cutaneous melanoma J Clin Oncol 23 2005 8048 8056
30. M. Grunkin Working with Visiomorph 2008 Visiopharm A/S Hørsholm, Denmark
31. M. Grunkin, J. Raundahl, and N.T. Foged Practical considerations of image analysis and quantification of signal transduction IHC staining Methods Mol Biol 717 2011 143 154
32. M.E. Reichenheim Two-graph receiver operating characteristic Stata J 2 2002 351 357
33. E.A. O'Rourke, B. Balzer, C.I. Barry, and D.P. Frishberg Nevic mitoses: a review of 1041 cases Am J Dermatopathol 35 2013 30 33
34. A.J. Miller, and M.C. Mihm Jr. Melanoma N Engl J Med 355 2006 51 65