Estrogen receptor expression in lumbar intervertebral disc of the elderly: Gender- and degeneration degree-related variations

Joint Bone Spine

Volumn 81, Issue 3, 2014, Pages 250-253

  Song, Xiao xing ^a   Yu, Yong juan ^a   Li, Xin feng ^a   Liu, Zu de ^a   Yu, Bu wei ^a   Guo, Zhen ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Degeneration; Estrogen receptor; Intervertebral disc; Nucleus pulposus

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA;

AGED; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GERIATRIC PATIENT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERVERTEBRAL DISK DEGENERATION; LUMBAR DISK; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS PULPOSUS; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE;

DEGENERATION; ESTROGEN RECEPTOR; INTERVERTEBRAL DISC; NUCLEUS PULPOSUS;

AGED; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; LUMBAR VERTEBRAE; MAGNETIC RESONANCE IMAGING; MALE; SEX FACTORS;

EID: 84901416906     PISSN: 1297319X     EISSN: 17787254     Source Type: Journal    
DOI: 10.1016/j.jbspin.2013.09.002     Document Type: Article

References (25)

1. Hughes S.P., Freemont A.J., Hukins D.W., et al. The pathogenesis of degeneration of the intervertebral disc and emerging therapies in the management of back pain. J Bone Joint Surg Br 2012, 94:1298-1304.
2. Manson N.A., Goldberg E.J., Andersson G.B. Sexual dimorphism in degenerative disorders of the spine. Orthop Clin North Am 2006, 37:549-553.
3. Huffman K.M., Kraus W.E. Osteoarthritis and the metabolic syndrome: more evidence that the etiology of OA is different in men and women. Osteoarthritis Cartilage 2012, 20:603-604.
4. Wang Y.X., Kwok A.W., Griffith J.F., et al. Relationship between hip bone mineral density and lumbar disc degeneration: a study in elderly subjects using an eight-level MRI-based disc degeneration grading system. J Magn Reson Imaging 2011, 33:916-920.
5. Wang Y.X., Griffith J.F., Ma H.T., et al. Relationship between gender, bone mineral density, and disc degeneration in the lumbar spine: a study in elderly subjects using an eight-level MRI-based disc degeneration grading system. Osteoporos Int 2011, 22:91-96.
6. Wang Y.X., Griffith J.F., Zeng X.J., et al. Prevalence and gender difference of lumbar disc space narrowing in elderly Chinese men and women: Mr OS (Hong Kong) and Ms. OS (Hong Kong) studies. Arthritis Rheum 2013, 65:1004-1010.
7. Calleja-Agius J., Muscat-Baron Y., Brincat M.P. Estrogens and the intervertebral disc. Menopause Int 2009, 15:127-130.
8. Wang T., Zhang L., Huang C., et al. Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats. Calcif Tissue Int 2004, 75:205-213.
9. Gambacciani M., Pepe A., Cappagli B., et al. The relative contributions of menopause and aging to postmenopausal reduction in intervertebral disk height. Climacteric 2007, 10:298-305.
10. Baron Y.M., Brincat M.P., Galea R., et al. Intervertebral disc height in treated and untreated overweight post-menopausal women. Hum Reprod 2005, 20:3566-3570.
11. Brincat M., Moniz C.J., Studd J.W., et al. Long-term effects of the menopause and sex hormones on skin thickness. Br J Obstet Gynaecol 1985, 92:256-259.
12. Gruber H.E., Yamaguchi D., Ingram J., et al. Expression and localization of estrogen receptor-beta in annulus cells of the human intervertebral disc and the mitogenic effect of 17-beta-estradiol in vitro. BMC Musculoskelet Disord 2002, 3:4.
13. Li X.F., Wang S.J., Jiang L.S., et al. Gender- and region-specific variations of estrogen receptor α and β expression in the growth plate of spine and limb during development and adulthood. Histochem Cell Biol 2012, 137:79-95.
14. Pfirrmann C.W., Metzdorf A., Zanetti M., et al. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine 2001, 26:1873-1878.
15. Tsai T.T., Lai P.L., Liao J.C., et al. Increased periostin gene expression in degenerative intervertebral disc cells. Spine J 2013, 13:289-298.
16. Reis Rodrigues L.M., de Oliveira L.Z., da Silva Pinhal M.A. The expression of heparanase isoforms in intervertebral discs classified according to Pfirrmann's grading system for disc degeneration. Spine 2013, 38:1112-1118.
17. Li X.F., Yan J., Jiang L.S., Dai L.Y. Age-related variations of leptin receptor expression in the growth plate of spine and limb: gender- and region-specific changes. Histochem Cell Biol 2011, 135:487-497.
18. Calleja-Agius J., Brincat M.P. Effects of hormone replacement therapy on connective tissue: why is this important?. Best Pract Res Clin Obstet Gynaecol 2009, 23:121-127.
19. Deng M., Griffith J.F., Zhu X.M., et al. Effect of ovariectomy on contrast agent diffusion into lumbar intervertebral disc: a dynamic contrast-enhanced MRI study in female rats. Magn Reson Imaging 2012, 30:683-688.
20. Rowas S.A., Haddad R., Gawri R., et al. Effect of in utero exposure to diethylstilbestrol on lumbar and femoral bone, articular cartilage, and the intervertebral disc in male and female adult mice progeny with and without swimming exercise. Arthritis Res Ther 2012, 14:R17.
21. Wang Y.X., Griffith J.F. Effect of menopause on lumbar disk degeneration: potential etiology. Radiology 2010, 257:318-320.
22. Mueller S.O., Korach K.S. Estrogen receptors and endocrine diseases: lessons from estrogen receptor knockout mice. Curr Opin Pharmacol 2001, 1:613-619.
23. de Schepper E.I., Damen J., van Meurs J.B., et al. The association between lumbar disc degeneration and low back pain: the influence of age, gender, and individual radiographic features. Spine 2010, 35:531-536.
24. Griffith J.F., Wang Y.X., Antonio G.E., et al. Modified Pfirrmann grading system for lumbar intervertebral disc degeneration. Spine 2007, 32:E708-E712.
25. Lin K., Jenis L. Degenerative lumbar spondylolisthesis. Semin Spine Surg 2003, 15:150-159.