Exogenous lactate supplementation to the injured brain: Misleading conclusions with clinical implications

Intensive Care Medicine

Volumn 40, Issue 6, 2014, Pages 919-

  Nordström, Carl Henrik ^a   Nielsen, Troels Halfeld ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUTAMIC ACID; LACTATE SODIUM; LACTIC ACID; PYRUVIC ACID;

BLOOD BRAIN BARRIER; DIET SUPPLEMENTATION; ENERGY METABOLISM; ENERGY YIELD; GLUCOSE BLOOD LEVEL; GLUCOSE BRAIN LEVEL; GLYCOLYSIS; HUMAN; INTRACRANIAL PRESSURE; LETTER; MICRODIALYSIS; OXIDATION REDUCTION STATE; TRAUMATIC BRAIN INJURY; BRAIN; BRAIN INJURY;

BRAIN; BRAIN INJURIES; HUMANS; LACTIC ACID;

EID: 84901413261     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-014-3297-5     Document Type: Letter

References (5)

1. Bouzat P, Sala N, Zerlaut JB, Marques- Vidal P, Feihl F, Bloch J, Messerer M, Levivier M, Meuli R, Magistretti PJ, Oddo M (2014) Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain. Int Care Med 40:412-421. doi: 10.1007/s00134-013-3203-6
2. van Hall G, Stromstad M, Rasmussen P, Jans O, Zaar M, Gam C, Quistorff B, Secher NH, Nielsen HB (2009) Blood lactate is an important energy source for the human brain. J Cereb Blood Flow Metab 29:1121-1129
3. Dienel GA (2012) Brain lactate metabolism: the discoveries and the controversies. J Cereb Blood Flow Metab 32:1107-1138
4. Nielsen TH, Olsen NV, Toft P, Nordstrom CH (2013) Cerebral energy metabolism during mitochondrial dysfunction induced by cyanide in piglets. Acta Anaesthesiol Scand 57:793-801
5. Fenstermacher JD (1984) Volume regulation of the central nervous system. In: Staub NC, Taylor AE (eds) Edema. Raven, New York, pp 383-404