Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity

Aging Cell

Volumn 13, Issue 3, 2014, Pages 457-467

  Hu, Jia ^a   Wei, Min ^a   Mirzaei, Hamed ^a   Madia, Federica ^a   Mirisola, Mario ^a,b   Amparo, Camille ^a   Chagoury, Shawna ^a   Kennedy, Brian ^c   Longo, Valter D ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF PALERMO   (Italy)

^c BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Acetic acid; Aging; Chronological lifespan; Leucine; Sch9

Indexed keywords

ACETIC ACID; ACETOACETIC ACID; ALCOHOL; COENZYME A TRANSFERASE; FUNGAL PROTEIN; KETONE BODY; LEUCINE; SCH9 PROTEIN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR; TREHALOSE; UBIQUINONE; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; SACCHAROMYCES CEREVISIAE PROTEIN; SCH9 PROTEIN KINASE; TOR1 PROTEIN, S CEREVISIAE;

ACIDIFICATION; AGING; ARTICLE; AUXOTROPHY; BREATHING PATTERN; CARBON SOURCE; CATABOLISM; CELL SURVIVAL; CONTROLLED STUDY; FUNGAL CELL CULTURE; GLYCOGEN ANALYSIS; LIFE EXTENSION; LIFESPAN; LONGEVITY; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PH; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SACCHAROMYCES CEREVISIAE; STARVATION; STRESS; TOR SCH9 DEFICIENCY; DEFICIENCY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY;

EUKARYOTA; MAMMALIA;

ACETIC ACID; HUMANS; LONGEVITY; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TREHALOSE;

EID: 84901407922     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12202     Document Type: Article

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