Evolution, mechanisms, and applications of Intein-mediated protein splicing

Journal of Biological Chemistry

Volumn 289, Issue 21, 2014, Pages 14488-14489

  Perler, Francine B ^a   Allewell, Norma M ^b  

^a NEW ENGLAND BIOLABS   (United States)

^b Bldg 142   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

BIOLOGICAL FUNCTIONS; ENZYMATIC REACTION; EVOLUTIONARY BIOLOGISTS; HORMONE RECEPTORS; PROTEIN-SPLICING; SIMPLE TECHNOLOGY; SYNTHETIC CHEMISTS; THREE-DIMENSIONAL STRUCTURE;

PROTEINS;

BIOFUEL; HORMONE RECEPTOR; INTEIN; LIGAND;

BIOSENSOR; ENZYME MECHANISM; HUMAN; INTEIN MEDIATED PROTEIN SPLICING; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW;

BIOTECHNOLOGY; ENZYME MECHANISMS; HEDGEHOG; PROTEIN ENGINEERING; PROTEIN EVOLUTION; PROTEIN PROCESSING; PROTEIN STRUCTURE;

ANIMALS; BIOTECHNOLOGY; EVOLUTION, MOLECULAR; GENOME; HUMANS; INTEINS; PROTEIN ENGINEERING; PROTEIN SPLICING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; TRANS-SPLICING;

EID: 84901403221     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.R114.570531     Document Type: Review

References (5)

1. Novikova, O., Topilina, N., and Belfort, M. (2014) Enigmatic distribution, evolution, and function of inteins. J. Biol. Chem. 289, 14490-14497.
2. Hall, T. M., Porter, J. A., Young, K. E., Koonin, E. V., Beachy, P. A., and Leahy, D. J. (1997) Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins. Cell 91, 85-97. (Pubitemid 27431315)
3. Eryilmaz, E., Shah, N., Muir, T., and Cowburn, D. (2014) Structural and dynamical features of inteins and implications on protein splicing. J. Biol. Chem. 289, 14506-14511.
4. Mills, K. V., Johnson, M. A., and Perler, F. B. (2014) Protein splicing: how inteins escape from precursor proteins. J. Biol. Chem. 289, 14498-14505.
5. Wood, D. W., and Camarero, J. A. (2014) Intein applications: from protein purification and labeling to metabolic control methods. J. Biol. Chem. 289, 14512-14519.