Polyethylene Glycol (PEG) Linked to Near Infrared (NIR) dyes conjugated to chimeric Anti-Carcinoembryonic Antigen (CEA) antibody enhances imaging of liver metastases in a nude-mouse model of human colon cancer

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Maawy, Ali A ^a   Hiroshima, Yukihiko ^b,c   Zhang, Yong ^b   Luiken, George A ^d   Hoffman, Robert M ^a,b   Bouvet, Michael ^a,e  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b ANTICANCER INC   (United States)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d OncoFluor Inc   (United States)

^e VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIBODY; DYLIGHT 650; DYLIGHT 750; FLUORESCENT DYE; MACROGOL; UNCLASSIFIED DRUG; CARCINOEMBRYONIC ANTIGEN; HYBRID PROTEIN; MACROGOL DERIVATIVE; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL LABELING; COLON CANCER; CONJUGATION; CONTROLLED STUDY; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IMAGE QUALITY; INFRARED RADIATION; LIVER METASTASIS; MOUSE; NONHUMAN; TISSUE DISTRIBUTION; ULTRASOUND; ANIMAL; CHEMISTRY; COLON TUMOR; DIAGNOSTIC USE; DISEASE MODEL; HT 29 CELL LINE; IMMUNOLOGY; LIVER; LIVER NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; PROCEDURES; SECONDARY; SIGNAL NOISE RATIO; TUMOR CELL LINE; WHOLE BODY IMAGING;

ANIMALS; ANTIBODIES, MONOCLONAL; CARCINOEMBRYONIC ANTIGEN; CELL LINE, TUMOR; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; FLUORESCENT DYES; HT29 CELLS; HUMANS; LIVER; LIVER NEOPLASMS; MICE, NUDE; OPTICAL IMAGING; POLYETHYLENE GLYCOLS; RECOMBINANT FUSION PROTEINS; SIGNAL-TO-NOISE RATIO; WHOLE BODY IMAGING;

EID: 84901391725     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097965     Document Type: Article

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