Protein and Amino Acid Metabolism and Requirements

Fetal and Neonatal Physiology E-Book, Fourth Edition

Volumn , Issue , 2011, Pages 603-614

  Kashyap, Sudha ^a,b   Heird, William C ^c  

^a Babies Hospital   (United States)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84901372064     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4160-3479-7.10056-4     Document Type: Chapter

References (113)

1. J.X. Chipponi, J.C. Bleier, M.T. Santi, et al. (1982) Deficiencies of essential and conditionally essential nutrients. Am J Clin Nutr 35(Suppl 5), 1112-1116.
2. A.E. Harper (1983) Dispensable and indispensable amino acid interrelationships. G.L. Blackburn, J.P. Grant, V.R. Young, et al., (Eds) Amino Acids: Metabolism and Medical Applications Boston: John Wright-PSG 105-121.
3. S.A. Laidlaw and J.D. Kopple (1987) Newer concepts of the indispensable amino acids. Am J Clin Nutr 46 593-605.
4. G.E. Gaull, J.A. Sturman and N.C. Raiha (1972) Development of mammalian sulphur metabolism: absence of cystathionase in human fetal tissues. Pediatr Res 6 538-547.
5. J.A. Sturman, G. Gaull and N.C. Raiha (1970) Absence of cystathionase in human fetal liver: is cysteine essential? Science 169 74-76.
6. S.H. Zlotkin and G.H. Anderson (1982) The development of cystathionase activity during the first year of life. Pediatr Res 16 65-68.
7. O. Greengard (1977) Enzymic differentiation of human liver: comparison with the rat model. Pediatr Res 11 669-676.
8. N.C. Raiha and J. Suihkonen (1968) Development of urea-synthesizing enzymes in human liver. Acta Paediatr Scand 57 121-124.
9. P.J. Reeds and T.A. Davis (1999) Of flux and flooding: the advantages and problems of different isotopic methods for quantifying protein turnover in vivo. I. Methods based on the dilution of a tracer. Curr Opin Clin Nutr Metab Care 2 23-28.
10. T. Inubushi, M. Shikiji, K. Endo, et al. (1996) Hormonal and dietary regulation of lysosomal cysteine proteinases in liver under gluconeogenesis conditions. Biol Chem 377 539-1342.
11. A. Ciehanover, J.A. DiGuiseppe, B. Bercovich, et al. (1991) Degradation of nuclear oncoproteins by the ubiquitin system in vitro. Proc Natl Acad Sci U S A 88 139-143.
12. A.L. Goldberg and K.L. Rock (1992) Proteolysis, proteasomes and antigen presentation. Nature 357 375-379.
13. J.C. Waterlow (1984) Protein turnover with special reference to man. Q J Exp Physiol 69 409-438.
14. Y.M. Yu, D.A. Wagner, E.E. Tredget, et al. (1990) Quantitative role of splanchnic region in leucine metabolism: L-[1-13C,15N] leucine and substrate balance studies. Am J Physiol 259 E36-E51.
15. L.J. Wykes, R.O. Ball, C.E. Menendez, et al. (1992) Glycine, leucine, and phenylalanine flux in low-birth-weight infants during parenteral and enteral feeding. Am J Clin Nutr 55 971-975.
16. L. van Toledo-Eppinga, S.C. Kalhan, W. Kulik, et al. (1996) Relative kinetics of phenylalanine and leucine in low birth weight infants during nutrient administration. Pediatr Res 40 41-46.
17. D.H. Calloway, A.C. Odell and S. Margen (1971) Sweat and miscellaneous nitrogen losses in human balance studies. J Nutr 101 775-786.
18. J.H. Cissik, R.E. Johnson and D.K. Rokosch (1972) Production of gaseous nitrogen in human steady-state conditions. J Appl Physiol 32 155-159.
19. C. Catzeflis, Y. Schutz, J.L. Micheli, et al. (1985) Whole body protein synthesis and energy expenditure in very low birth weight infants. Pediatr Res 19 679-687.
20. W.C. Heird, S. Kashyap, K.F. Schulze, et al. (1987) Nutrient utilization and growth in LBW infants. A. Goldman, S. Atkinson, et al., (Eds) Human Lactation 3: The Effects of Human Milk on the Recipient Infant New York: Plenum Press 9-21.
21. B. Reichman, P. Chessex, G. Verellen, et al. (1983) Dietary composition and macronutrient storage in preterm infants. Pediatrics 72 322-328.
22. American Academy of Pediatrics Committee on Nutrition (1998) Nutritional needs of preterm infants. R.E. Kleinman (Eds) Pediatric Nutrition Handbook Elk Grove Village, IL: American Academy of Pediatrics 55-87.
23. Canadian Pediatric Society Nutrition Committee (1995) Nutrition needs and feeding of premature infants. Can Med Assoc J 152 1765-1785.
24. European Society for Gastroenterology (1987) Hepatology, and Nutrition, Committee on Nutrition of the Preterm Infant: Nutrition and feeding of preterm infants. Acta Paediatr Scand Suppl 336 1-14.
25. S. Kashyap, K.F. Schulze, M. Forsyth, et al. (1990) Growth, nutrient retention and metabolic response of low-birth-weight infants fed supplemented and unsupplemented preterm human milk. Am J Clin Nutr 52 254-262.
26. S. Kashyap and W.C. Heird (1994) Protein requirements of low birthweight, very low birthweight, and small for gestational age infants. N.C.R. Räihä (Eds) Protein Metabolism During Infancy: Nestlé Nutrition Workshop Series, vol 33 New York: Raven Press 133.
27. G.A. Zello, C.E. Menendez, M. Rafii, et al. (2003) Minimum protein intake for the preterm neonate determined by protein and amino acid kinetics. Pediatr Res 53 338-344.
28. S. Kashyap, K.F. Schulze, M. Forsyth, et al. (1988) Growth, nutrient retention and metabolic response in low birth weight infants fed varying intakes of protein and energy. J Pediatr 113 713-721.
29. S. Kashyap, M. Forsyth, C. Zucker, et al. (1986) Effects of varying protein and energy intakes on growth and metabolic response in low birth weight infants. J Pediatr 108 955-963.
30. W.B. Pittard III, K.M. Geddes and T.A. Picone (1988) Cord blood amino acid concentrations from neonates of 23–41 weeks gestational age. JPEN J Parenter Enteral Nutr 12 167-169.
31. N. McIntosh, C.H. Rodeck and R. Heath (1984) Plasma amino acids of the midtrimester human fetus. Biol Neonate 45 218-224.
32. R.J. Schanler (1985) Nitrogen and mineral balance in preterm infants fed human milks or formula. J Pediatr Gastroenterol Nutr 4 214-219.
33. J.P. Shenai, J.W. Reynolds and S.G. Babson (1980) Nutritional balance studies in very low birth weight infants: enhanced nutrient retention rates by an experimental formula. Pediatrics 66 233-238.
34. J.E. Tyson, R.E. Lasky, C.E. Mize, et al. (1983) Growth, metabolic response and development in very low birth weight infants fed banked human milk or enriched formula. I. Neonatal findings. J Pediatr 103 95-104.
35. R.A. Ehrenkranz, N. Younes, J.A. Lemons, et al. (1999) Longitudinal growth of hospitalized very low birth weight infants. Pediatrics 104 280-289.
36. Life Sciences Research Office (LSRO) (2002) Expert Panel on Assessment of Nutrient Requirements for Preterm Infant Formulas. J Nutr 132(Suppl), 1395S-1577S.
37. W.C. Rose (1957) The amino acid requirements of adult man. Nutr Abstr Rev Ser Hum Exp 27 631-647.
38. V.R. Young, C. Meredith, R. Hoerr, et al. (1985) Amino acid kinetics in relation to protein and amino acid requirements: the primary importance of amino acid oxidation. J.S. Garrow, D. Halliday (Eds) Substrate and Energy Metabolism in Man London: John Libbey 119-134.
39. L.E. Holt Jr. and S.E. Snyderman (1967) The amino acid requirements of children. W.L. Nyhan (Eds) Amino Acid Metabolism and Genetic Variation New York: McGraw-Hill 381-390.
40. P.B. Pencharz and R.O. Ball (2003) Different approaches to define individual amino acid requirements. Annu Rev Nutr 23 101-116.
41. D.R. Mager, L.J. Wykes, R.O. Ball, et al. (2003) Branched chain amino acid requirements in school aged children determined by indicator amino acid oxidation. J Nutr 133 3540-3545.
42. S.A. Roberts, R.O. Ball, A.M. Moore, et al. (2001) The effect of graded intake of glycyl-L-tyrosine on phenylalanine and tyrosine metabolism in parenterally fed neonates, with an estimation of tyrosine requirements. Pediatr Res 49 111-119.
43. S.E. Snyderman (1971) The protein and amino acid requirements of the premature infant. J.H.P. Jonxis, H.K.A. Visser, J.A. Troelstra (Eds) Metabolic Processes in the Foetus and Newborn Infant Leiden, Holland: Stenfert Kroese 128-141.
44. S.E. Snyderman (1975) Amino acid requirements. R.W. Winters, E.G. Hasselmeyer (Eds) Intravenous Nutrition in the High Risk Infant New York: John Wiley & Sons 205-214.
45. S.J. Fomon and L.J. Filer Jr. (1967) Amino acid requirements for normal growth. W.L. Nyhan (Eds) Amino Acid Metabolism and Genetic Variation New York: McGraw-Hill 391-401.
46. Life Sciences Research Office (1992) Safety of Amino Acids Used as Dietary Supplements: FDA Contract No. 223-88-2124 Washington, DC: Food and Drug Administration (FDA) Center for Food Safety and Applied Nutrition
47. W.E. Heine, P.D. Klein and P.J. Reeds (1991) The importance of α-lactalbumin in infant nutrition. J Nutr 121 277-283.
48. A.J. Darragh and P.H. Moughan (1998) The amino acid composition of human milk corrected for amino acid digestibility. Br J Nutr 80 25-34.
49. T.A. Davis, H.V. Nguyen, R. Garcia-Bravo, et al. (1994) Amino acid composition of human milk is not unique. J Nutr 124 1126-1132.
50. S. Villalpando, N.F. Butte, S. Flores-Huerta, et al. (1998) Qualitative analysis of human milk produced by women consuming a maize-predominant diet typical of rural Mexico. Ann Nutr Metab 42 23-32.
51. E.M. Widdowson, D.A.T. Southgate and E.N. Hey (1979) Body composition of the fetus and infant. H.K.A. Visser (Eds) Fifth Nutricia Symposium: Nutrition and Metabolism of the Fetus and Infant The Hague: Martinus Nijhoff 169-177.
52. N.C.R. Räihä (1974) Biochemical basis for nutritional management of preterm infants. Pediatrics 53 147-156.
53. S.C. Denne, C.A. Karn, J.A. Ahlrichs, et al. (1996) Proteolysis and phenylalanine hydroxylation in response to parenteral nutrition in extremely premature and normal newborns. J Clin Invest 97 746-954.
54. R.A. Kilani, F.S. Cole and D.M. Bier (1995) Phenylalanine hydroxylase activity in preterm infants: is tyrosine a conditionally essential amino acid? Am J Clin Nutr 61 1218-1223.
55. A.A. Jackson, J.C. Shaw, A. Barber, et al. (1981) Nitrogen metabolism in preterm infants fed human donor breast milk: the possible essentiality of glycine. Pediatr Res 15 1454-1461.
56. R.G. Miller, F. Jahoor and T. Jaksic (1995) Decreased cysteine and proline synthesis in parenterally fed, premature infants. J Pediatr Surg 30 953-957.
57. T.R. Ziegler, E.E. Szeszycki, C.F. Estivariz, et al. (1996) Glutamine: from basic science to clinical applications. Nutrition 12(Suppl), S68-S70.
58. J. Neu, J.C. Roig, W.H. Meetz, et al. (1997) Enteral glutamine supplementation for very low birth weight infants decreases morbidity. J Pediatr 131 691-699.
59. S.H. Zlotkin, M.H. Bryan and G.H. Anderson (1981) Intravenous nitrogen and energy intakes required to duplicate in utero nitrogen accretion in prematurely born human infants. J Pediatr 99 115-120.
60. R.W. Winters, W.C. Heird, R.B. Dell, et al. (1977) Plasma amino acids in infants receiving parenteral nutrition. H.L. Greene, M.A. Holliday, H.N. Munro (Eds) Clinical Nutrition Update: Amino Acids Chicago: American Medical Association 147-157.
61. L.D. Stegink and G.L. Baker (1971) Infusion of protein hydrolysates in the newborn infant: plasma amino acid concentrations. J Pediatr 78 595-602.
62. W.C. Heird, R.B. Dell, R.A. Helms, et al. (1987) Amino acid mixture designed to maintain normal plasma amino acid patterns in infants and children requiring parenteral nutrition. Pediatrics 80 401-408.
63. W.C. Heird, W. Hay, R.A. Helms, et al. (1988) Pediatric parenteral amino acid mixture in low birth weight infants. Pediatrics 81 41-50.
64. C.V. Smith, T.N. Hansen, N.E. Martin, et al. (1993) Oxidant stress responses in premature infants during exposure to hyperoxia. Pediatr Res 34 360-365.
65. S. Kashyap, A. Abildskov and W.C. Heird (1992) Cysteine supplementation of very low birth weight infants receiving parenteral nutrition. Pediatr Res 31 290A.
66. M.R. Mendoza, J.W. Sparks and A. Rivera (1993) Cysteine supplementation increases whole blood glutathione concentration in parenterally fed preterm infants. Pediatr Res 33 307A.
67. R.A. Helms, M.L. Christensen, E.C. Mauer, et al. (1987) Comparison of a pediatric versus standard amino acid formulation in preterm neonates requiring parenteral nutrition. J Pediatr 110 466-470.
68. B. Duffy, T. Gunn, J. Collinge, et al. (1981) The effect of varying protein quality and energy intake on the nitrogen metabolism of parenterally fed very low birth weight (less than 1600 g) infants. Pediatr Res 15 1040-1044.
69. J.H. Shaw and R.R. Wolfe (1989) An integrated analysis of glucose, fat, and protein metabolism in severely traumatized patients: studies in the basal state and the response to total parenteral nutrition. Ann Surg 209 63-72.
70. G. Biolo, G. Toigo, B. Ciocchi, et al. (1997) Metabolic response to injury and sepsis: changes in protein metabolism. Nutrition 13(Suppl), 52S-57S.
71. F.D. Moore (1959) Metabolic Care of the Surgical Patient. Philadelphia: Saunders 409–456
72. C.L. Long, R.H. Birkhahn, J.W. Geiger, et al. (1981) Urinary excretion of 3-methylhistidine: an assessment of muscle protein catabolism in adult normal subjects and during malnutrition, sepsis, and skeletal trauma. Metabolism 30 765-776.
73. H.J. Smeets, J. Kievit, H.I. Harinck, et al. (1995) Differential effects of counterregulatory stress hormones on serum albumin concentrations and protein catabolism in healthy volunteers. Nutrition 11 423-427.
74. E. Lofberg, A. Gutierrez, J. Wernerman, et al. (2002) Effects of high doses of glucocorticoids on free amino acids, ribosomes and protein turnover in human muscle. Eur J Clin Invest 32 345-353.
75. H. Ensinger, W. Geisser, A. Brinkmann, et al. (2002) Metabolic effects of norepinephrine and dobutamine in healthy volunteers. Shock 18 495-500.
76. J.C. Waterlow (1991) Protein-energy malnutrition: challenges and controversies. Proc Nutr Soc India 37 59-86.
77. P.J. Reeds, C.R. Fjeld and F. Jahoor (1994) Do the differences between the amino acid compositions of acute-phase and muscle proteins have a bearing on nitrogen loss in traumatic states? J Nutr 124 906-910.
78. O. Knutrud (1965) The Water and Electrolyte Metabolism in the Newborn Child After Major Surgery. Oslo: Universitets Forlaget
79. B. Duffy and P. Pencharz (1986) The effects of surgery on the nitrogen metabolism of parenterally fed human neonates. Pediatr Res 20 32.
80. G. Boehm, W. Handrick, F.B. Spencker, et al. (1986) Effects of bacterial sepsis on protein metabolism in infants during the first week. Biomed Biochim Acta 45 813-819.
81. J.D. Mrozek, M.K. Georgieff, B.R. Blazar, et al. (2000) Effect of sepsis syndrome on neonatal protein and energy metabolism. J Perinatol 20 96-100.
82. T.L. Anderson, C.R. Muttart, M.A. Bieber, et al. (1979) A controlled trial of glucose vs. glucose and amino acids in premature infants. J Pediatr 94 947-951.
83. A. Rivera Jr., E.F. Bell and D.M. Bier (1993) Effect of intravenous amino acids on protein metabolism of preterm infants during the first three days of life. Pediatr Res 33 106-111.
84. R.A. van Lingen, J.B. van Goudoever, I.H. Luijendijk, et al. (1992) Effects of early amino acid administration during total parenteral nutrition on protein metabolism in pre-term infants. Clin Sci (Colch) 82 199-203.
85. J. Saini, P. MacMahon, J.B. Morgan, et al. (1989) Early parenteral feeding of amino acids. Arch Dis Child 64 1362-1366.
86. S.J. Fomon, E.E. Ziegler, L.J. Filer, et al. (1979) Methionine fortification of a soy protein formula fed to infants. Am J Clin Nutr 32 2460-2471.
87. J.H. Menkes, D.W. Welcher, H.S. Levi, et al. (1972) Relationship of elevated blood tyrosine to the ultimate intellectual performance of premature infants. Pediatrics 49 218-224.
88. S. Kashyap, E. Okamoto, S. Kanaya, et al. (1987) Protein quality in feeding low birth weight infants: a comparison of whey-predominant versus casein-predominant formulas. Pediatrics 79 748-755.
89. N.C. Räihä, K. Heinonen, D.K. Rassin, et al. (1976) Milk protein quality in low-birth-weight infants. I. Metabolic response and effects on growth. Pediatrics 57 659-684.
90. D.H. Calloway and H. Spector (1954) Nitrogen balance as related to caloric and protein intake in active young men. Am J Clin Nutr 2 405-412.
91. H.N. Munro (1964) General aspects of the regulation of protein metabolism by diet and by hormones. III. Influence of dietary carbohydrate and fat on protein metabolism. H.N. Munro (Eds) Mammalian Protein Metabolism New York: Academic Press 412-447.
92. M. Pineault, P. Chessex, S. Bisaillon, et al. (1988) Total parenteral nutrition in the newborn: impact of the quality of infused energy on nitrogen metabolism. Am J Clin Nutr 47 298-304.
93. S. Kashyap, K.F. Schulze, R. Ramakrishnan, et al. (1994) Evaluation of a mathematical model for predicting the relationship between protein and energy intakes of low-birth-weight infants and the rate and composition of weight gain. Pediatr Res 35 704-712.
94. J.M. Long III, D.W. Wilmore, A.D. Mason Jr., et al. (1977) Effect of carbohydrate and fat intake on nitrogen excretion during total intravenous feeding. Ann Surg 185 417-422.
95. S. Kashyap, K. Ohira-Kist, K. Abildskov, et al. (2001) Effects of quality of energy on growth and metabolic response in enterally fed low birth weight infants. Pediatr Res 50 390-397.
96. D.J. Millward and J.P.W. Rivers (1986) The effect of dietary energy and protein on growth as studied in animal models. S.J. Fomon, W.C. Heird (Eds) Energy and Protein Needs During Infancy New York: Academic Press 127-156.
97. B. Reichman, P. Chessex, G. Putet, et al. (1981) Diet, fat accretion and growth in premature infants. N Engl J Med 305 1495-1500.
98. K.F. Schulze, M. Stefanski, J. Masterson, et al. (1987) Energy expenditure, energy balance and composition of weight gain in low birth weight infants fed diets of different protein and energy content. J Pediatr 110 753-759.
99. R.K. Whyte, R. Haslam, C. Vlainic, et al. (1983) Energy balance and nitrogen balance in growing low birth weight infants fed human milk or formula. Pediatr Res 17 891-898.
100. D. Rudman, W.J. Millikan, T.J. Richardson, et al. (1975) Elemental balances during intravenous hyperalimentation of underweight adult subjects. J Clin Invest 55 94-104.
101. E.M. Widdowson (1974) Changes in body proportion and composition during growth. J. Davis, J. Dobbing (Eds) Scientific Foundations of Pediatrics Philadelphia: Saunders 153-163.
102. D.J. Hill and R.D.G. Milner (1985) Insulin as a growth factor. Pediatr Res 19 879-886.
103. N.K. Fukagawa, K.L. Minaker, J.W. Rowe, et al. (1985) Insulin-mediated reduction of whole body protein breakdown: dose-response effects on leucine metabolism in postabsorptive men. J Clin Invest 76 2306-2311.
104. P. Tessari, R. Trevisan, S. Inchiostro, et al. (1986) Dose-response curves of effects of insulin on leucine kinetics in humans. Am J Physiol 251 E334-E342.
105. B.B. Pointdexter, C.A. Karn and S.C. Denne (1998) Exogenous insulin reduces proteolysis and protein synthesis in extremely low birth weight infants. J Pediatr 132 948-953.
106. D. Le Roith, L. Scavo and A. Butler (2001) What is the role of circulating IGF-I? Trends Endocrinol Metab 12 48-52.
107. D.L. Russell-Jones, A.M. Umpleby, T.R. Hennessy, et al. (1994) Use of a leucine clamp to demonstrate that IGF-I actively stimulates protein synthesis in normal humans. Am J Physiol 267 E591-E598.
108. W. Shen, P. Wisniowski, L. Ahmed, et al. (2002) Protein anabolic effects of insulin and IGF-I in the ovine fetus. Am J Physiol 284 E748-E756.
109. J.O. Jorgensen, et al. (1989) Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1 1221-1225.
110. F. Salomon, R.C. Cuneo, R. Hesp, et al. (1989) The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 321 1797-1803.
111. D.A. Fryburg, R.A. Gelfand and E.J. Barrett (1991) Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans. Am J Physiol 260 E499-E504.
112. E.F. Horber and M.W. Haymond (1990) Human growth hormone prevents the protein catabolic side effects of prednisone in humans. J Clin Invest 86 265-272.
113. G. Tonini, T. Pahor, F. Colonna, et al. (1997) Growth hormone does not prevent catabolic side effects of dexamethasone in extremely low birth weight preterm infants with bronchopulmonary dysplasia: a pilot study. J Pediatr Endocrinol Metab 10 291-294.