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•• Stern RM, Koch KL, Andrews P. Nausea: mechanisms and management. USA: Oxford University Press; 2011. This first comprehensive book on nausea provides an in-depth review on the multiple causes, mechanisms, physiological basis and management of various causes of nausea. • A collaboration between a gastroenterologist, a psychologist and a physiologist, this book provides a multidimensional overview on the many possible mechanisms of nausea.
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Functional MRI study on subjects with vection-induced nausea by visual stimulus • Increased activation was noted in brain regions involved in fear processing, stress and emotions preceding the transition to strong nausea • A larger brain network including interoceptive, limbic, somatosensory and cognitive processing also showed activation following sustained nausea sensation
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•• Napadow V, Sheehan JD, Kim J, et al. The brain circuitry underlying the temporal evolution of nausea in humans. Cereb Cortex. 2013;23(4):806-13. Functional MRI study on subjects with vection-induced nausea by visual stimulus • Increased activation was noted in brain regions involved in fear processing, stress and emotions preceding the transition to strong nausea • A larger brain network including interoceptive, limbic, somatosensory and cognitive processing also showed activation following sustained nausea sensation.
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This article outlines the consensus opinion behind the 2006 Rome III criteria for functional gastroduodenal disorders • The classification includes four categories of functional gastroduodenal disorders: 1 functional dyspepsia (with subcategories of postprandial distress syndrome and epigastric pain syndrome); 2 belching disorders; 3 nausea and vomiting disorders (including chronic idiopathic nausea); and 4 rumination syndrome
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• Tack J, Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130(5):1466-79. This article outlines the consensus opinion behind the 2006 Rome III criteria for functional gastroduodenal disorders • The classification includes four categories of functional gastroduodenal disorders: 1) functional dyspepsia (with subcategories of postprandial distress syndrome and epigastric pain syndrome); 2) belching disorders; 3) nausea and vomiting disorders (including chronic idiopathic nausea); and 4) rumination syndrome.
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This study describes a very high prevalence of nausea in a large cohort of pain-associated functional GI disorders • 60% (96 of 160 subjects) suffered from nausea, 53% of these had nausea a least 2x/week and 28% had daily nausea• Notably, nausea was associated with social disability in both home and school settings beyond the effects of pain
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• Kovacic K, Williams S, Li BUK, Chelimsky G, Miranda A. High prevalence of nausea in children with pain-associated functional gastrointestinal disorders: are Rome criteria applicable? J Pediatr Gastroenterol Nutr. 2013;57(3):311-5. This study describes a very high prevalence of nausea in a large cohort of pain-associated functional GI disorders • 60% (96 of 160 subjects) suffered from nausea, 53% of these had nausea a least 2x/week and 28% had daily nausea• Notably, nausea was associated with social disability in both home and school settings beyond the effects of pain.
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A retrospective study comparing the characteristics of 45 children with primary chronic nausea to 49 children with nausea as a secondary complaint (to functional abdominal pain) • The primary chronic nausea group had more severe symptoms and some characteristic features such as a personal and/or family history of migraines, a diagnosis of POTS and more co-morbid complaints of dizziness, fatigue and anxiety
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• Kovacic K, Miranda A, Chelimsky G, et al. Chronic idiopathic nausea of childhood. J Pediatr. 2014;164(5):1104-9. A retrospective study comparing the characteristics of 45 children with primary chronic nausea to 49 children with nausea as a secondary complaint (to functional abdominal pain) • The primary chronic nausea group had more severe symptoms and some characteristic features such as a personal and/or family history of migraines, a diagnosis of POTS and more co-morbid complaints of dizziness, fatigue and anxiety.
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