Immunocytochemical studies of cellular reaction in human ischemic brain stroke. MAB anti-CD68 stains macrophages, astrocytes and microglial cells in infarcted area

Folia Neuropathologica

Volumn 34, Issue 1, 1996, Pages 16-24

  Krupiński, Jerzy ^a,b   Kałuza, Józef ^a   Kumar, Pat ^b   Kumar, Shant ^c  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

^c CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

Astrocytes; Brain ischemic stroke; MAB anti CD 68; Macrophages; Microglia

Indexed keywords

LEUKOCYTE ANTIGEN;

AGED; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CULTURE TECHNIQUE; HUMAN; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MICROGLIA; MIDDLE AGED; PATHOPHYSIOLOGY; ULTRASTRUCTURE;

AGED; ANTIGENS, CD; ASTROCYTES; BRAIN ISCHEMIA; CULTURE TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MICROGLIA; MIDDLE AGED;

EID: 84901361527     PISSN: 00283894     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Aleksandrovskaya M: Vascular disorders of the brain in various pathological states. Moscow, Mir Publisher, 1995, 308.
2. Bignami A, Eng LF, Dahl D, Uyeda CT: Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Brain Res, 1972, 43, 429-435.
3. Blakemore W: Microglial reactions following thermal necrosis of the rat cortex: an electron microscopic study. Acta Neuropathol (Berl), 1972, 21, 11-22.
4. Blinzinger K, Kreutzberg G: Displacement of synaptic terminals from regenerating motoneurons by microglial cells. Z. Zellforsch, 1968, 85, 145-157.
5. Bogolepov N: Ultrastructure of the brain in hypoxia. Mir Publisher, Moscow, 1983.
6. Brierley JB, Brown AW: The origin of lipid phagocytes in the central nervous system. I. The intrinsic microglia. J Comp Neurol, 1982a, 211, 397-406.
7. Brierley JB, Brown AW: II. The adventitia of blood vessels. J Comp Neurol, 1982b, 211, 407-417.
8. Fonatana A, Erb P, Pircher H, Zinkernagel R, Weber E, Fierz W: Astrocytes as antigen presenting cells. Part II. Unlike H-2K dependent cytotoxic Tcells, H-2Ia-restricted Tcells are only stimulated in the presence of interferon-gamma. J Neuroimmunol, 1986, 12, 15-17.
9. Frohman EN, Van den Noort S, Gupta S: Astrocytes and intracerebral immune response. J Clin Immunol, 1989, 9, 1-9.
10. Grogaard B, Schurer L, Gerdin B, Arfors KE: Delayed hypoperfusion after incomplete forebrain ischemia in rat: the role of polymorphonuclear leukocytes. J Cereb Blood Flow Metab, 1989, 9, 500-505.
11. Guarini L, Temponi N, Bruce JN, Bollon AP, Duigon GK J, Moulton TA, Ferrone S, Fisher PF: Expression and modulation by cytokines of the intercellular adhesion molecule 1 (ICAM1) in human central nervous system tumor cell cultures. Int J Cancer, 46, 1041-1047.
12. Guilian D, Baker TJ: Peptides released by ameboid microglia regulate astroglial proliferation. J Cell Biol, 1985, 101, 2411-2415.
13. Guilian D, Lachman LB: Interleukin1 stimulation of astroglial proliferation after brain injury. Science, 1985, 228, 497-499.
14. Guilian D, Vaca K, Corpuz M: Brain glia release factors with opposing actions upon neuronal survival. A novel class of neuron killing molecules. J Neurosci, 1993, 13, 29-37.
15. Kałuża J, Adamek D, Bujny T: Immunocytochemical analysis of cellular infiltrates in primary glial and metastatic tumors in human brain. Patol Pol, 1993, 44, 65-73.
16. Kałuża J, Krupiński J, Kumar P, Kumar S, Wang JM: VCAM1 expression on reactive and tumor astrocytes. Folia Histochem Cytobiol, 1994, 32, 17-20.
17. Kochanek P, Hallenbeck J: Polymorphonuclear leukocytes and monocytes/macrophages in pathogenesis of cerebral ischemia and stroke. Stroke, 1992, 23, 9, 1367-1369.
18. Konigsmark B, Sidman R: Origin of brain macrophages in mouse. J Neuropathol Exp Neurol, 1963, 22, 327.
19. Krupiński J, Kałuża J, Kumar P, Kumar S, Wang JM: Prognostic value of blood vessel density in ischemic stroke. Lancet, 1993a, 342, 742.
20. Krupiński J, Kałuża J, Kumar P, Kumar S, Wang JM: Some remarks on the growth-rate and angiogenesis of microvessels in ischemic stroke. Morphometric and immunocytochemical studies. Patol Pol, 1993b, 44, 203-209.
21. Kuppner MC, Van Meir E, Hamen MF, de Tribolet N: Cytokine regulation of intercellular adhesion molecule-ICAM-1 expression on human glioblastoma cells. Clin Exp Immunol, 1990, 81, 142-148.
22. Lindsberg PJ, Siren AL, Feuerstein GZ, Hallenbeck JM: Postischemic antagonism of neutrophil adherence has an acute therapeutic effect on functional recovery in the deteriorating stroke model in rabbits. J Cereb Blood Flow Metab, 1991, 11, 754.
23. Mori S, Leblond C: Identification of microglia in light and electron microscopy. J Comp Neurol, 1969, 135, 57-79.
24. Movat HZ: Tumor necrosis factor and interleukin1: role in acute inflammation and microvascular injury. J Lab Clin Med, 1987, 110, 668-681.
25. Mugnaini E, Walberb F: Ultrastructure of neuroglia. Ergeb Anat Entwickl Gesch, 1964, 37, 194-236.
26. Oppenheimer-Marks N, Devis LS, Tompkins Bogue D, Ramberg J, Lipsky PE: Differential utilization of ICAM-1 and VCAM-1 during the adhesion of transendothelial migration of human T lymphocytes. J Immunol, 1991, 147, 2913-2921.
27. Plata-Salaman CR: Immunomodulators and feeding regulation: a humoral link between the immune and nervous system. Brain Behav Immunol, 1989, 3, 193-213.
28. Pober JS, Cotran RS: What can be learnt from expression of endothelial adhesion molecules in tissues. Lab Invest, 1991, 64, 301-305.
29. Polverini PJ: Macrophage induced angiogenesis: a review in Cytokines. C Sorg (ed), S Karger, Basel, 1989.
30. Ridley A, Cavanagh JB: Lymphocytic infiltration in gliomas: evidence of possible host resistance. Brain, 1971, 94, 117-124.
31. Rosenman SJ, Shrikant P, Lindsey D, Benveniste EN, Ransohoff RM: Cytokine induced expression of vascular cells adhesion molecule 1 (VCAM-1) by astrocytes and astrocytoma cell lines. J Immunol, 1995, 154, 1888-1899.
32. Rossler CK, Neuchrist C, Kitz K, Schiner O, Kraft D, Lassman H: Expression of leukocyte adhesion molecules at the human blood brain barrier (BBB). J Neurosci Res, 1992, 31, 365-374.
33. Sawamura Y, de Tribolet N: Immunotherapy of brain tumors. J Neurosurg Sci, 1990, 34, 265-278.
34. Schelper RL, Adrian EK: Monocytes become macrophages, they do not become microglia: a light and electron microscopic autoradiographic study using 125-iododeoxyuridine. J Neuropathol Exp Neurol, 1986, 45, 1-19.
35. Shinonaga M, Chang CC, Suzuki N, Kuwabara T: Immunohistological evaluation of macrophage infiltrates in brain tumors. Correlation with peritumoral edema. J Neurosurg, 1988, 68, 259-265.
36. Sternberegr LA, Hardy PH, Cuculis JJ, Mayer HG: The unlabelled antibody enzyme method for immunohistochemical preparation and properties of soluble antigen-antibody complex (horse-radish-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem, 1970, 18, 315-333.
37. Torvik A: Phagocytosis of nerve cells during retrograde degeneration. An electron microscopic study. J Neuropathol Exp Neurol, 1972, 31, 132-146.