Wormholes in Host Defense: How Helminths Manipulate Host Tissues to Survive and Reproduce

PLoS Pathogens

Volumn 10, Issue 4, 2014, Pages

  Boyett, Deborah ^a   Hsieh, Michael H ^b  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SECRETORY PROTEIN; VASCULOTROPIN;

ARTICLE; BRUGIA MALAYI; CERCARIA; DIROFILARIA IMMITIS; EPITHELIUM HYPERPLASIA; GRANULOMA; HELIGMOSOMOIDES POLYGYRUS; HELMINTH; HOST PARASITE INTERACTION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INTESTINE EPITHELIUM CELL; LYMPHOID TISSUE; MEMBRANE DAMAGE; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; PARASITE SURVIVAL; PARASITOSIS; PEYER PATCH; SCHISTOSOMA HEMATOBIUM; SCHISTOSOMA MANSONI; SKIN EPITHELIUM; STRONGYLOIDES STERCORALIS; TRICHINELLA SPIRALIS; TRICHURIS TRICHIURA; VASCULARIZATION; ADAPTATION; ANIMAL; HELMINTHIASIS; IMMUNOLOGY; PHYSIOLOGY; REPRODUCTION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; HELMINTHIASIS; HELMINTHS; HOST-PARASITE INTERACTIONS; HUMANS; REPRODUCTION;

EID: 84901317851     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004014     Document Type: Article

References (30)

1. Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, et al. (2008) Helminth infections: the great neglected tropical diseases. J Clin Invest 118: 1311-1321 Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2276811&tool=pmcentrez&rendertype=abstract. Accessed 3 September 2013.
2. Ingram J, Knudsen G, Lim KC, Hansell E, Sakanari J, et al. (2011) Proteomic analysis of human skin treated with larval schistosome peptidases reveals distinct invasion strategies among species of blood flukes. PLoS Negl Trop Dis 5: e1337 Available: http://dx.plos.org/10.1371/journal.pntd.0001337. Accessed 8 August 2013.
3. Dresden MH, Asch HL, (1972) Proteolytic enzymes in extracts of Schistosoma mansoni Cercariae. Biochim Biophys Acta 289: 378-384 Available: http://www.sciencedirect.com/science/article/pii/0005274472900897. Accessed 18 December 2013.
4. Curwen RS, Ashton PD, Sundaralingam S, Wilson RA, (2006) Identification of novel proteases and immunomodulators in the secretions of schistosome cercariae that facilitate host entry. Mol Cell Proteomics 5: 835-844 Available: http://www.mcponline.org/content/5/5/835.short. Accessed 18 December 2013.
5. Ray D, Nelson TA, Fu C-L, Patel S, Gong DN, et al. (2012) Transcriptional profiling of the bladder in urogenital schistosomiasis reveals pathways of inflammatory fibrosis and urothelial compromise. PLoS Negl Trop Dis 6: e1912 Available: http://dx.plos.org/10.1371/journal.pntd.0001912. Accessed 2 August 2013.
6. Drake L, Korchev Y, Bashford L, Djamgoz M, Wakelin D, et al. (1994) The major secreted product of the whipworm, Trichuris, is a pore-forming protein. Proc Biol Sci 257: 255-261 Available: http://rspb.royalsocietypublishing.org/content/257/1350/255. Accessed 14 August 2013.
7. Drake LJ, Barker GC, Korchev Y, Lab M, Brooks H, et al. (1998) Molecular and functional characterization of a recombinant protein of Trichuris trichiura. Proc Biol Sci 265: 1559-1565 Available: http://rspb.royalsocietypublishing.org/content/265/1405/1559.short. Accessed 18 December 2013.
8. Barker GC, Bundy DAP, (1999) Isolation of a gene family that encodes the porin-like proteins from the human parasitic nematode Trichuris trichiura. Gene 229: 131-136 Available: http://www.sciencedirect.com/science/article/pii/S0378111999000396. Accessed 18 December 2013.
9. Werneck-Silva AL, Alvares EP, Gama P, Damião AOMC, Osaki LH, et al. (2006) Intestinal damage in strongyloidiasis: the imbalance between cell death and proliferation. Dig Dis Sci 51: 1063-1069 Available: http://www.ncbi.nlm.nih.gov/pubmed/16865572. Accessed 29 August 2013.
10. Xia C-M, Zhao Y, Jiang L, Jiang J, Zhang S-C, (2011) Schistosoma japonicum ova maintains epithelial barrier function during experimental colitis. World J Gastroenterol 17: 4810-4816 Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3229631&tool=pmcentrez&rendertype=abstract. Accessed 5 August 2013.
11. Višnjar T, Kocbek P, Kreft ME, (2012) Hyperplasia as a mechanism for rapid resealing urothelial injuries and maintaining high transepithelial resistance. Histochem Cell Biol 137: 177-186 Available: http://www.ncbi.nlm.nih.gov/pubmed/22127649. Accessed 3 September 2013.
12. Kamal M, Dehlawis MS, Rosa Brunet L, Wakelin D, (2003) Paneth and intermediate cell hyperplasia induced in mice by helminth infections. Parasitology 125: 275-281 Available: http://journals.cambridge.org/abstract_S0031182002002068. Accessed 3 September 2013.
13. Turner JD, Narang P, Coles MC, Mountford AP, (2012) Blood flukes exploit Peyer's Patch lymphoid tissue to facilitate transmission from the mammalian host. PLoS Pathog 8: e1003063 Available: http://dx.plos.org/10.1371/journal.ppat.1003063. Accessed 30 May 2013.
14. Bennuru S, Nutman TB, (2009) Lymphangiogenesis and lymphatic remodeling induced by filarial parasites: implications for pathogenesis. PLoS Pathog 5: e1000688 Available: http://dx.plos.org/10.1371/journal.ppat.1000688. Accessed 9 August 2013.
15. Nelson FK, (1991) The immunodeficient scid mouse as a model for human lymphatic filariasis. J Exp Med 173: 659-663 Available: http://jem.rupress.org/content/173/3/659.abstract. Accessed 3 September 2013.
16. Morchón R, González-Miguel J, Mellado I, Velasco S, Rodríguez-Barbero A, et al. (2010) Adult Dirofilaria immitis excretory/secretory antigens upregulate the production of prostaglandin E2 and downregulate monocyte transmigration in an "in vitro" model of vascular endothelial cell cultures. Vet Parasitol 170: 331-335 Available: http://dx.doi.org/10.1016/j.vetpar.2010.02.034. Accessed 30 August 2013.
17. Kang Y-J, Jo J-O, Cho M-K, Yu H-S, Ock MS, et al. (2011) Trichinella spiralis infection induces angiogenic factor thymosin β4 expression. Vet Parasitol 181: 222-228 Available: http://dx.doi.org/10.1016/j.vetpar.2011.03.058. Accessed 21 August 2013.
18. Despommier D, (1998) How Does Trichinella spiralis Make Itself at Home? Parasitol Today 14: 318-323 Available: http://www.sciencedirect.com/science/article/pii/S0169475898012873. Accessed 4 February 2014.
19. Maeda H, Wu J, Sawa T, Matsumura Y, Hori K, (2000) Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 65: 271-284 Available: http://www.sciencedirect.com/science/article/pii/S0168365999002485. Accessed 17 December 2013.
20. Doenhoff MJ, Hassounah O, Murare H, Bain J, Lucas S, (1986) The schistosome egg granuloma: immunopathology in the cause of host protection or parasite survival? Trans R Soc Trop Med Hyg 80: 503-514 Available: http://www.ncbi.nlm.nih.gov/pubmed/3492792. Accessed 26 November 2013.
21. Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, et al. (1992) Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature 356: 604-607 Available: http://dx.doi.org/10.1038/356604a0. Accessed 18 December 2013.
22. Fallon PG, Richardson EJ, Smith P, Dunne DW, (2000) Elevated type 1, diminished type 2 cytokines and impaired antibody response are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice. Eur J Immunol 30: 470-480 Available: http://onlinelibrary.wiley.com/doi/10.1002/1521-4141(200002)30:2<470::AID-IMMU470>3.0.CO;2-T/abstract. Accessed 17 December 2013.
23. De Oliveira Fraga LA, Torrero MN, Tocheva AS, Mitre E, Davies SJ, (2010) Induction of type 2 responses by schistosome worms during prepatent infection. J Infect Dis 201: 464-472 Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2842083&tool=pmcentrez&rendertype=abstract. Accessed 17 December 2013.
24. Hams E, Aviello G, Fallon PG, (2013) The schistosoma granuloma: friend or foe? Front Immunol 4: 89 Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3625856&tool=pmcentrez&rendertype=abstract. Accessed 22 May 2013.
25. Anthony RM, Rutitzky LI, Urban JF, Stadecker MJ, Gause WC, (2007) Protective immune mechanisms in helminth infection. Nat Rev Immunol 7: 975-987 Available: http://dx.doi.org/10.1038/nri2199. Accessed 6 August 2013.
26. Vella AT, Hulsebosch MD, Pearce EJ, (1992) Schistosoma mansoni eggs induce antigen-responsive CD44-hi T helper 2 cells and IL-4-secreting CD44-lo cells. Potential for T helper 2 subset differentiation is evident at the precursor level. J Immunol 149: 1714-1722 Available: http://www.jimmunol.org/content/149/5/1714.abstract. Accessed 18 December 2013.
27. Wang I-C, Fan P-C, Lu S-C, Fan C-K, Su K-E, (2008) Suppression of host Th1-type granulomatous inflammation by Taenia solium metacestodes is related to down-regulation of osteopontin gene expression. Int J Parasitol 38: 239-248 Available: http://dx.doi.org/10.1016/j.ijpara.2007.07.010. Accessed 30 August 2013.
28. White AC, (2000) Neurocysticercosis: updates on epidemiology, pathogenesis, diagnosis, and management. Annu Rev Med 51: 187-206 Available: http://www.annualreviews.org/doi/abs/10.1146/annurev.med.51.1.187. Accessed 6 December 2013.
29. García HH, Gonzalez AE, Evans CA, Gilman RH, (2003) Taenia solium cysticercosis. Lancet 362: 547-556 Available: http://www.sciencedirect.com/science/article/pii/S0140673603141177. Accessed 19 December 2013.
30. Rabinovich GA, Gabrilovich D, Sotomayor EM, (2007) Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 25: 267-296 Available: http://www.annualreviews.org/doi/full/10.1146/annurev.immunol.25.022106.141609. Accessed 12 December 2013.