메뉴 건너뛰기




Volumn 42, Issue 9, 2014, Pages 5644-5656

The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast

Author keywords

[No Author keywords available]

Indexed keywords

9 1 1 COMPLEX; CHECKPOINT KINASE 1; NUCLEIC ACID BINDING PROTEIN; RAD17 PROTEIN; UNCLASSIFIED DRUG;

EID: 84901315410     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku190     Document Type: Article
Times cited : (27)

References (60)
  • 1
    • 81955161844 scopus 로고    scopus 로고
    • DNA double-strand break repair pathways, chromosomal rearrangements and cancer
    • Kasparek, T.R. and Humphrey, T.C. (2011) DNA double-strand break repair pathways, chromosomal rearrangements and cancer. Semin. Cell Dev. Biol., 22, 886-897
    • (2011) Semin. Cell Dev. Biol , vol.22 , pp. 886-897
    • Kasparek, T.R.1    Humphrey, T.C.2
  • 2
    • 0023712476 scopus 로고
    • The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
    • Weinert, T.A. and Hartwell, L.H. (1988) The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science, 241, 317-322
    • (1988) Science , vol.241 , pp. 317-322
    • Weinert, T.A.1    Hartwell, L.H.2
  • 3
    • 0037312919 scopus 로고    scopus 로고
    • Direct kinase-To-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase
    • Bashkirov, V.I., Bashkirova, E.V., Haghnazari, E. and Heyer, W.D. (2003) Direct kinase-To-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase. Mol. Cell. Biol., 23, 1441-1452
    • (2003) Mol. Cell. Biol , vol.23 , pp. 1441-1452
    • Bashkirov, V.I.1    Bashkirova, E.V.2    Haghnazari, E.3    Heyer, W.D.4
  • 4
    • 0032161269 scopus 로고    scopus 로고
    • A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
    • Zhao, X., Muller, E.G. and Rothstein, R. (1998) A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell, 2, 329-340
    • (1998) Mol. Cell , vol.2 , pp. 329-340
    • Zhao, X.1    Muller, E.G.2    Rothstein, R.3
  • 6
    • 0033612287 scopus 로고    scopus 로고
    • Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
    • DOI 10.1016/S0092-8674(00)80773-4
    • Martin, S.G., Laroche, T., Suka, N., Grunstein, M. and Gasser, S.M. (1999) Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell, 97, 621-633. (Pubitemid 29256965
    • (1999) Cell , vol.97 , Issue.5 , pp. 621-633
    • Martin, S.G.1    Laroche, T.2    Suka, N.3    Grunstein, M.4    Gasser, S.M.5
  • 7
    • 0038141976 scopus 로고    scopus 로고
    • Colocalization of multiple DNA double-strand breaks at a single Rad52 repair center
    • DOI 10.1038/ncb997
    • Lisby, M., Mortensen, U.H. and Rothstein, R. (2003) Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre.Nat. Cell Biol., 5, 572-577. (Pubitemid 36781093
    • (2003) Nature Cell Biology , vol.5 , Issue.6 , pp. 572-577
    • Lisby, M.1    Mortensen, U.H.2    Rothstein, R.3
  • 8
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • Harper, J.W. and Elledge, S.J. (2007) The DNA damage response: Ten years after. Mol. Cell, 28, 739-745
    • (2007) Mol. Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 9
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham, R.T. (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev., 15, 2177-2196
    • (2001) Genes Dev , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 10
    • 4243156107 scopus 로고    scopus 로고
    • Biochemical characterization of DNA damage checkpoint complexes: Clamp loader and clamp complexes with specificity for 5' recessed DNA
    • Ellison, V. and Stillman, B. (2003) Biochemical characterization of DNA damage checkpoint complexes: Clamp loader and clamp complexes with specificity for 5' recessed DNA. PLoS Biol., 1, E33
    • (2003) PLoS Biol , vol.1
    • Ellison, V.1    Stillman, B.2
  • 11
    • 0033965418 scopus 로고    scopus 로고
    • A novel Rad24 checkpoint protein complex closely related to replication factor C
    • Green, C.M., Erdjument-Bromage, H., Tempst, P. and Lowndes, N.F. (2000) A novel Rad24 checkpoint protein complex closely related to replication factor C. Curr. Biol., 10, 39-42
    • (2000) Curr. Biol , vol.10 , pp. 39-42
    • Green, C.M.1    Erdjument-Bromage, H.2    Tempst, P.3    Lowndes, N.F.4
  • 12
    • 0033582906 scopus 로고    scopus 로고
    • A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins
    • Thelen, M.P., Venclovas, C. and Fidelis, K. (1999) A slidi g clamp model for the Rad1 family of cell cycle checkpoint proteins. Cell, 96, 769-770. (Pubitemid 29165080
    • (1999) Cell , vol.96 , Issue.6 , pp. 769-770
    • Thelen, M.P.1    Venclovas, C.2    Fidelis, K.3
  • 13
    • 0037418195 scopus 로고    scopus 로고
    • Yeast rad17/mec3/ddc1: A sliding clamp for the dna damage checkpoint
    • Majka, J. and Burgers, P.M. (2003) Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint. Proc. Natl. Acad. Sci. U.S.A., 100, 2249-2254
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 2249-2254
    • Majka, J.1    Burgers, P.M.2
  • 14
  • 15
    • 0037567268 scopus 로고    scopus 로고
    • Sensing dna damage through atrip recognition of rpa-ssdna complexes
    • DOI 10.1126/science.1083430
    • Zou, L. and Elledge, S.J. (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science, 300, 1542-1548. (Pubitemid 36682880
    • (2003) Science , vol.300 , Issue.5625 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 16
    • 42949130159 scopus 로고    scopus 로고
    • Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
    • Bonilla, C.Y., Melo, J.A. and Toczyski, D.P. (2008) Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol. Cell, 30, 267-276
    • (2008) Mol. Cell , vol.30 , pp. 267-276
    • Bonilla, C.Y.1    Melo, J.A.2    Toczyski, D.P.3
  • 17
    • 2442646547 scopus 로고    scopus 로고
    • topbp1
    • DOI 10.1101/gad.291104
    • Furuya, K., Poitelea, M., Guo, L., Caspari, T. and Carr, A.M. (2004) Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-Terminal BRCT domains of Rad4TOPBP1. Genes Dev., 18, 1154-1164. (Pubitemid 38669036
    • (2004) Genes and Development , vol.18 , Issue.10 , pp. 1154-1164
    • Furuya, K.1    Poitelea, M.2    Guo, L.3    Caspari, T.4    Carr, A.M.5
  • 18
    • 71149093704 scopus 로고    scopus 로고
    • The unstructured c-Terminal tail of the 9-1-1 clamp subunit ddc1 activates mec1/atr via two distinct mechanisms
    • Navadgi-Patil, V.M. and Burgers, P.M. (2009) The unstructured C-Terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms. Mol. Cell, 36, 743-753
    • (2009) Mol. Cell , vol.36 , pp. 743-753
    • Navadgi-Patil, V.M.1    Burgers, P.M.2
  • 19
    • 0031438163 scopus 로고    scopus 로고
    • Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1
    • Saka, Y., Esashi, F., Matsusaka, T., Mochida, S. and Yanagida, M. (1997) Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev., 11, 3387-3400. (Pubitemid 28023961
    • (1997) Genes and Development , vol.11 , Issue.24 , pp. 3387-3400
    • Saka, Y.1    Esashi, F.2    Matsusaka, T.3    Mochida, S.4    Yanagida, M.5
  • 21
    • 0035736486 scopus 로고    scopus 로고
    • Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1
    • DOI 10.1038/ncb1101-966
    • Tanaka, K. and Russell, P. (2001) Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.Nat. Cell Biol., 3, 966-972. (Pubitemid 34428741
    • (2001) Nature Cell Biology , vol.3 , Issue.11 , pp. 966-972
    • Tanaka, K.1    Russell, P.2
  • 22
    • 0030768948 scopus 로고    scopus 로고
    • Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase
    • DOI 10.1126/science.277.5331.1495
    • Furnari, B., Rhind, N. and Russell, P. (1997) Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science, 277, 1495-1497. (Pubitemid 27449235
    • (1997) Science , vol.277 , Issue.5331 , pp. 1495-1497
    • Furnari, B.1    Rhind, N.2    Russell, P.3
  • 23
    • 0032496322 scopus 로고    scopus 로고
    • Replication checkpoint enforced by kinases Cds1 and Chk1
    • DOI 10.1126/science.280.5365.909
    • Boddy, M.N., Furnari, B., Mondesert, O. and Russell, P. (1998) Replication checkpoint enforced by kinases Cds1 and Chk1. Science, 280, 909-912. (Pubitemid 28215602
    • (1998) Science , vol.280 , Issue.5365 , pp. 909-912
    • Boddy, M.N.1    Furnari, B.2    Mondesert, O.3    Russell, P.4
  • 24
    • 0032190082 scopus 로고    scopus 로고
    • Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1
    • Zeng, Y., Forbes, K.C., Wu, Z., Moreno, S., Piwnica-Worms, H. and Enoch, T. (1998) Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature, 395, 507-510
    • (1998) Nature , vol.395 , pp. 507-510
    • Zeng, Y.1    Forbes, K.C.2    Wu, Z.3    Moreno, S.4    Piwnica-Worms, H.5    Enoch, T.6
  • 25
    • 0033552943 scopus 로고    scopus 로고
    • Nuclear localization of cdc25 is regulated by dna damage and a 14-3-3 protein
    • Lopez-Girona, A., Furnari, B., Mondesert, O. and Russell, P. (1999) Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature, 397, 172-175
    • (1999) Nature , vol.397 , pp. 172-175
    • Lopez-Girona, A.1    Furnari, B.2    Mondesert, O.3    Russell, P.4
  • 26
    • 0025021753 scopus 로고
    • Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication
    • Enoch, T. and Nurse, P. (1990) Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell, 60, 665-673
    • (1990) Cell , vol.60 , pp. 665-673
    • Enoch, T.1    Nurse, P.2
  • 27
    • 0035830498 scopus 로고    scopus 로고
    • Suppression of spontaneous chromosomal rearrangements by s phase checkpoint functions in saccharomyces cerevisiae
    • DOI 10.1016/S0092-8674(01)00227-6
    • Myung, K., Datta, A. and Kolodner, R.D. (2001) Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell, 104, 397-408. (Pubitemid 32206460
    • (2001) Cell , vol.104 , Issue.3 , pp. 397-408
    • Myung, K.1    Datta, A.2    Kolodner, R.D.3
  • 28
    • 0035963338 scopus 로고    scopus 로고
    • Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae
    • DOI 10.1038/35082608
    • Myung, K., Chen, C. and Kolodner, R.D. (2001) Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature, 411, 1073-1076. (Pubitemid 32612334
    • (2001) Nature , vol.411 , Issue.6841 , pp. 1073-1076
    • Myung, K.1    Chen, C.2    Kolodner, R.D.3
  • 29
    • 0037356692 scopus 로고    scopus 로고
    • Induction of genome instability by DNA damage in Saccharomyces cerevisiae
    • DOI 10.1016/S1568-7864(02)00216-1, PII S1568786402002161
    • Myung, K. and Kolodner, R.D. (2003) Induction of genome instability by DNA damage in Saccharomyces cerevisiae. DNA Repair (Amst), 2, 243-258. (Pubitemid 36126395
    • (2003) DNA Repair , vol.2 , Issue.3 , pp. 243-258
    • Myung, K.1    Kolodner, R.D.2
  • 30
    • 0037007074 scopus 로고    scopus 로고
    • Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae
    • Myung, K. and Kolodner, R.D. (2002) Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A., 99, 4500-4507
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 4500-4507
    • Myung, K.1    Kolodner, R.D.2
  • 31
    • 30944462801 scopus 로고    scopus 로고
    • Cycles of chromosome instability are associated with a fragile site and are increased by defects in dna replication and checkpoint controls in yeast
    • DOI 10.1101/gad.1392506
    • Admire, A., Shanks, L., Danzl, N., Wang, M., Weier, U., Stevens, W., Hunt, E. and Weinert, T. (2006) Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast. Genes Dev., 20, 159-173. (Pubitemid 43112935
    • (2006) Genes and Development , vol.20 , Issue.2 , pp. 159-173
    • Admire, A.1    Shanks, L.2    Danzl, N.3    Wang, M.4    Weier, U.5    Stevens, W.6    Hunt, E.7    Weinert, T.8
  • 33
    • 0035155661 scopus 로고    scopus 로고
    • ATM, a central controller of cellular responses to DNA damage
    • DOI 10.1038/sj.cdd.4400874
    • Khanna, K.K., Lavin, M.F., Jackson, S.P. and Mulhern, T.D. (2001) ATM, a central controller of cellular responses to DNA damage. Cell Death Differ., 8, 1052-1065. (Pubitemid 33061823
    • (2001) Cell Death and Differentiation , vol.8 , Issue.11 , pp. 1052-1065
    • Khanna, K.K.1    Lavin, M.F.2    Jackson, S.P.3    Mulhern, T.D.4
  • 34
    • 0037451243 scopus 로고    scopus 로고
    • Pathway utilization in response to a site-specific DNA double-strand break in fission yeast
    • DOI 10.1093/emboj/cdg119
    • Prudden, J., Evans, J.S., Hussey, S.P., Deans, B., O'Neill, P., Thacker, J. and Humphrey, T. (2003) Pathway utilization in response to a site-specific DNA double-strand break in fission yeast. EMBO J., 22, 1419-1430. (Pubitemid 36362705
    • (2003) EMBO Journal , vol.22 , Issue.6 , pp. 1419-1430
    • Prudden, J.1    Evans, J.S.2    Hussey, S.P.3    Deans, B.4    O'Neill, P.5    Thacker, J.6    Humphrey, T.7
  • 36
    • 33645804000 scopus 로고    scopus 로고
    • Rqh1 blocks recombination between sister chromatids during double strand break repair independent of its helicase activity
    • Hope, J.C., Mense, S.M., Jalakas, M., Mitsumoto, J. and Freyer, G.A. (2006) Rqh1 blocks recombination between sister chromatids during double strand break repair, independent of its helicase activity. Proc. Natl. Acad. Sci. U.S.A., 103, 5875-5880
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 5875-5880
    • Hope, J.C.1    Mense, S.M.2    Jalakas, M.3    Mitsumoto, J.4    Freyer, G.A.5
  • 37
    • 39049140674 scopus 로고    scopus 로고
    • Urg1: A uracil-regulatable promoter system for fission yeast with short induction and repression times
    • Watt, S., Mata, J., Lopez-Maury, L., Marguerat, S., Burns, G. and Bahler, J. (2008) urg1: A uracil-regulatable promoter system for fission yeast with short induction and repression times. PLoS One, 3, e1428
    • (2008) PLoS One , vol.3
    • Watt, S.1    Mata, J.2    Lopez-Maury, L.3    Marguerat, S.4    Burns, G.5    Bahler, J.6
  • 38
    • 79960935163 scopus 로고    scopus 로고
    • Regulation of gene expression at the fission yeast schizosaccharomyces pombe urg1 locus
    • Watson, A.T., Werler, P. and Carr, A.M. (2011) Regulation of gene expression at the fission yeast Schizosaccharomyces pombe urg1 locus. Gene, 484, 75-85
    • (2011) Gene , vol.484 , pp. 75-85
    • Watson, A.T.1    Werler, P.2    Carr, A.M.3
  • 39
    • 35748954645 scopus 로고    scopus 로고
    • Break-induced loss of heterozygosity in fission yeast: Dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition
    • Cullen, J.K., Hussey, S.P., Walker, C., Prudden, J., Wee, B.Y., Dave, A., Findlay, J.S., Savory, A.P. and Humphrey, T.C. (2007) Break-induced loss of heterozygosity in fission yeast: Dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition. Mol. Cell. Biol., 27, 7745-7757
    • (2007) Mol. Cell. Biol , vol.27 , pp. 7745-7757
    • Cullen, J.K.1    Hussey, S.P.2    Walker, C.3    Prudden, J.4    Wee, B.Y.5    Dave, A.6    Findlay, J.S.7    Savory, A.P.8    Humphrey, T.C.9
  • 40
    • 33744942683 scopus 로고    scopus 로고
    • The fatc domains of pikk proteins are functionally equivalent and participate in the tip60-dependent activation of dna-pkcs and atm
    • Jiang, X., Sun, Y., Chen, S., Roy, K. and Price, B.D. (2006) The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J. Biol. Chem., 281, 15741-15746
    • (2006) J. Biol. Chem , vol.281 , pp. 15741-15746
    • Jiang, X.1    Sun, Y.2    Chen, S.3    Roy, K.4    Price, B.D.5
  • 41
    • 0028882869 scopus 로고
    • Yeast checkpoint genes in dna damage processing: Implications for repair and arrest
    • Lydall, D. and Weinert, T. (1995) Yeast checkpoint genes in DNA damage processing: Implications for repair and arrest. Science, 270, 1488-1491
    • (1995) Science , vol.270 , pp. 1488-1491
    • Lydall, D.1    Weinert, T.2
  • 43
    • 51949118680 scopus 로고    scopus 로고
    • Checkpoint-dependent phosphorylation of exo1 modulates the dna damage response
    • Morin, I., Ngo, H.P., Greenall, A., Zubko, M.K., Morrice, N. and Lydall, D. (2008) Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response. EMBO J., 27, 2400-2410
    • (2008) EMBO J. , vol.27 , pp. 2400-2410
    • Morin, I.1    Ngo, H.P.2    Greenall, A.3    Zubko, M.K.4    Morrice, N.5    Lydall, D.6
  • 44
    • 78649861218 scopus 로고    scopus 로고
    • Break-induced atr and ddb1-cul4(cdt)(2) ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast
    • Moss, J., Tinline-Purvis, H., Walker, C.A., Folkes, L.K., Stratford, M.R., Hayles, J., Hoe, K.L., Kim, D.U., Park, H.O., Kearsey, S.E. et al. (2010) Break-induced ATR and Ddb1-Cul4(Cdt)(2) ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast. Genes Dev., 24, 2705-2716
    • (2010) Genes Dev , vol.24 , pp. 2705-2716
    • Moss, J.1    Tinline-Purvis, H.2    Walker, C.A.3    Folkes, L.K.4    Stratford, M.R.5    Hayles, J.6    Hoe, K.L.7    Kim, D.U.8    Park, H.O.9    Kearsey, S.E.10
  • 45
    • 27844432597 scopus 로고    scopus 로고
    • + stimulates a pcu4-ddb1-csn ubiquitin ligase
    • DOI 10.1038/sj.emboj.7600854, PII 7600854
    • Liu, C., Poitelea, M., Watson, A., Yoshida, S.H., Shimoda, C., Holmberg, C., Nielsen, O. and Carr, A.M. (2005) Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase. EMBO J., 24, 3940-3951. (Pubitemid 41638000
    • (2005) EMBO Journal , vol.24 , Issue.22 , pp. 3940-3951
    • Liu, C.1    Poitelea, M.2    Watson, A.3    Yoshida, S.-H.4    Shimoda, C.5    Holmberg, C.6    Nielsen, O.7    Carr, A.M.8
  • 46
    • 0038185375 scopus 로고    scopus 로고
    • Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and-independent mechanisms
    • DOI 10.1101/gad.1090803
    • Liu, C., Powell, K.A., Mundt, K., Wu, L., Carr, A.M. and Caspari, T. (2003) Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and-independent mechanisms. Genes Dev., 17, 1130-1140. (Pubitemid 36534987
    • (2003) Genes and Development , vol.17 , Issue.9 , pp. 1130-1140
    • Liu, C.1    Powell, K.A.2    Mundt, K.3    Wu, L.4    Carr, A.M.5    Caspari, T.6
  • 47
    • 0042691728 scopus 로고    scopus 로고
    • The checkpoint protein Rad24 of Saccharomyces cerevisiae is involved in processing double-strand break ends and in recombination partner choice
    • Aylon, Y. and Kupiec, M. (2003) The checkpoint protein Rad24 of Saccharomyces cerevisiae is involved in processing double-strand break ends and in recombination partner choice. Mol. Cell. Biol., 23, 6585-6596
    • (2003) Mol. Cell. Biol , vol.23 , pp. 6585-6596
    • Aylon, Y.1    Kupiec, M.2
  • 48
    • 38349006294 scopus 로고    scopus 로고
    • The processing of double-strand breaks and binding of single-strand-binding proteins rpa and rad51 modulate the formation of atr-kinase foci in yeast
    • Dubrana, K., van Attikum, H., Hediger, F. and Gasser, S.M. (2007) The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast. J. Cell Sci., 120, 4209-4220
    • (2007) J. Cell Sci , vol.120 , pp. 4209-4220
    • Dubrana, K.1    Van Attikum, H.2    Hediger, F.3    Gasser, S.M.4
  • 49
    • 5144219712 scopus 로고    scopus 로고
    • Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants
    • DOI 10.1534/genetics.104.027904
    • Zubko, M.K., Guillard, S. and Lydall, D. (2004) Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants. Genetics, 168, 103-115. (Pubitemid 39346582
    • (2004) Genetics , vol.168 , Issue.1 , pp. 103-115
    • Zubko, M.K.1    Guillard, S.2    Lydall, D.3
  • 50
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu, Z., Chung, W.H., Shim, E.Y., Lee, S.E. and Ira, G. (2008) Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell, 134, 981-994
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5
  • 51
    • 68249116573 scopus 로고    scopus 로고
    • Dna end resection: Many nucleases make light work
    • Mimitou, E.P. and Symington, L.S. (2009) DNA end resection: Many nucleases make light work. DNA Repair (Amst). 8, 983-995
    • (2009) DNA Repair (Amst , vol.8 , pp. 983-995
    • Mimitou, E.P.1    Symington, L.S.2
  • 52
    • 84861974796 scopus 로고    scopus 로고
    • The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing
    • Hu, J., Sun, L., Shen, F., Chen, Y., Hua, Y., Liu, Y., Zhang, M., Hu, Y., Wang, Q., Xu, W. et al. (2012) The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing. Cell, 149, 1221-1232
    • (2012) Cell , vol.149 , pp. 1221-1232
    • Hu, J.1    Sun, L.2    Shen, F.3    Chen, Y.4    Hua, Y.5    Liu, Y.6    Zhang, M.7    Hu, Y.8    Wang, Q.9    Xu, W.10
  • 53
    • 68249113358 scopus 로고    scopus 로고
    • A tale of two tails: Activation of dna damage checkpoint kinase mec1/atr by the 9-1-1 clamp and by dpb11/topbp1
    • Navadgi-Patil, V.M. and Burgers, P.M. (2009) A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. DNA Repair (Amst), 8, 996-1003
    • (2009) DNA Repair (Amst , vol.8 , pp. 996-1003
    • Navadgi-Patil, V.M.1    Burgers, P.M.2
  • 54
    • 34547131331 scopus 로고    scopus 로고
    • Genetic dissection of parallel sister-chromatid cohesion pathways
    • DOI 10.1534/genetics.107.072876
    • Xu, H., Boone, C. and Brown, G.W. (2007) Genetic dissection of parallel sister-chromatid cohesion pathways. Genetics, 176, 1417-1429. (Pubitemid 47105206
    • (2007) Genetics , vol.176 , Issue.3 , pp. 1417-1429
    • Xu, H.1    Boone, C.2    Brown, G.W.3
  • 55
    • 77957363057 scopus 로고    scopus 로고
    • Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes
    • Covo, S., Westmoreland, J.W., Gordenin, D.A. and Resnick, M.A. (2010) Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes. PLoS Genet, 6, e1001006
    • (2010) PLoS Genet , vol.6
    • Covo, S.1    Westmoreland, J.W.2    Gordenin, D.A.3    Resnick, M.A.4
  • 56
    • 4143051517 scopus 로고    scopus 로고
    • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background
    • DOI 10.1038/sj.emboj.7600315
    • Fang, Y., Tsao, C.C., Goodman, B.K., Furumai, R., Tirado, C.A., Abraham, R.T. and Wang, X.F. (2004) ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J., 23, 3164-3174. (Pubitemid 39093610
    • (2004) EMBO Journal , vol.23 , Issue.15 , pp. 3164-3174
    • Fang, Y.1    Tsao, C.-C.2    Goodman, B.K.3    Furumai, R.4    Tirado, C.A.5    Abraham, R.T.6    Wang, X.-F.7
  • 58
    • 3142552523 scopus 로고    scopus 로고
    • Chk1 is haploinsufficient for multiple functions critical to tumor suppression
    • DOI 10.1016/j.ccr.2004.06.015, PII S1535610804001758
    • Lam, M.H., Liu, Q., Elledge, S.J. and Rosen, J.M. (2004) Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell, 6, 45-59. (Pubitemid 38903161
    • (2004) Cancer Cell , vol.6 , Issue.1 , pp. 45-59
    • Lam, M.H.1    Liu, Q.2    Elledge, S.J.3    Rosen, J.M.4
  • 60
    • 34250865564 scopus 로고    scopus 로고
    • CDC25 phosphatases in cancer cells: Key players? Good targets
    • Boutros, R., Lobjois, V. and Ducommun, B. (2007) CDC25 phosphatases in cancer cells: Key players? Good targets? Nat. Rev. Cancer, 7, 495-507
    • (2007) Nat Rev. Cancer , vol.7 , pp. 495-507
    • Boutros, R.1    Lobjois, V.2    Ducommun, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.