FLAG-induced remission in a patient with acute mast cell leukemia (MCL) exhibiting t(7;10)(q22;q26) and KIT D816H

Leukemia Research Reports

Volumn 3, Issue 1, 2014, Pages 8-13

  Valent, Peter ^a   Blatt, Katharina ^a   Eisenwort, Gregor ^a   Herrmann, Harald ^a   Cerny Reiterer, Sabine ^a   Thalhammer, Renate ^a   Müllauer, Leonhard ^a   Hoermann, Gregor ^a   Sadovnik, Irina ^a   Schwarzinger, Ilse ^a   Sperr, Wolfgang R ^a   Mannhalter, Christine ^a   Horny, Hans Peter ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Chemotherapy; FLAG; KIT; Mast cell leukemia; Mast cells

Indexed keywords

CYTARABINE; FLUDARABINE; TRYPTASE;

ACUTE LEUKEMIA; ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; BLOOD LEVEL; BONE MARROW EXAMINATION; CANCER RECURRENCE; CANCER STAGING; CASE REPORT; CAUSE OF DEATH; CHROMOSOME DELETION; CLINICAL EFFECTIVENESS; CLINICAL FEATURE; CYTOGENETICS; CYTOLOGY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; FOLLOW UP; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KARYOTYPE 46,XX; KIT GENE; LEUKOCYTE COUNT; MAST CELL; MAST CELL LEUKEMIA; MEDICAL HISTORY; MIDDLE AGED; MOLECULAR PATHOLOGY; MULTIPLE CYCLE TREATMENT; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL;

EID: 84901294850     PISSN: 22130489     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lrr.2013.11.001     Document Type: Article

References (20)

1. Valent P., Akin C., Sperr W.R., Horny H.P., Arock M., Lechner K. Diagnosis and treatment of systemic mastocytosis: state of the art. Br J Haematol 2003, 122(5):695-717.
2. Valent P., Akin C., Sperr W.R., Escribano L., Arock M., Horny H.P. Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria. Leuk Res 2003, 27(7):635-641.
3. Georgin-Lavialle S., Lhermitte L., Dubreuil P., Chandesris M.O., Hermine O., Damaj G. Mast cell leukemia. Blood 2013, 121(8):1285-1295.
4. Travis W.D., Li C.Y., Hoagland H.C., Travis L.B., Banks P.M. Mast cell leukemia: report of a case and review of the literature. Mayo Clin Proc 1986, 61(12):957-966.
5. Gotlib J., Berubé C., Growney J.D., Chen C.C., George T.I., Williams C., et al. Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. Blood 2005, 106(8):2865-2870.
6. Valent P., Akin C., Escribano L., Födinger M., Hartmann K., Brockow K. Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria. Eur J Clin Invest 2007, 37(6):435-453.
7. Escribano L., Diaz-Agustin B., López A., Núñez López R., García-Montero A., Almeida J., et al. Spanish Network on Mastocytosis (REMA). Immunophenotypic analysis of mast cells in mastocytosis: when and how to do it. Proposals of the Spanish Network on Mastocytosis (REMA). Cytom Part B Clin Cytom 2004, 58(1):1-8.
8. Sotlar K., Escribano L., Landt O., Möhrle S., Herrero S., Torrelo A., et al. One-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probes. Am J Pathol 2003, 162(3):737-746.
9. Sperr W.R., Escribano L., Jordan J.H., Schernthaner G.H., Kundi M., Horny H.P., et al. Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis. Leuk Res 2001, 25(7):529-536.
10. Valent P., Horny H.P., Escribano L., Longley B.J., Li C.Y., Schwartz L.B. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res 2001, 25(7):603-625.
11. Valent P., Horny H.-P., Li C.Y., Longley J.B., Metcalfe D.D., Parwaresch R.M. Mastocytosis (mast cell disease). World Health Organization (WHO) classification of tumours. Pathology & genetics. Tumours of haematopoietic and lymphoid tissues 2001, 291-302. IARC Press, Lyon, France. E.S. Jaffe, N.L. Harris, H. Stein, J.W. Vardiman (Eds.).
12. Horny H.P., Akin C., Metcalfe D.D., Akin C., Escribano L., Valent P. Mastocytosis (mast cell disease). World Health Organization (WHO) classification of tumours. Pathology & genetics. Tumours of haematopoietic and lymphoid tissues 2008, 54-63. IARC Press, Lyon, France. S.H. Swerdlow, E. Campo, N.L. Harris, E.S. Jaffe, S.A. Pileri, H. Stein, J. Thiele, J.W. Vardiman (Eds.).
13. Horny H.P., Valent P. Diagnosis of mastocytosis: general histopathological aspects, morphological criteria, and immunohistochemical findings. Leuk Res 2001, 25(7):543-551.
14. Sotlar K., Cerny-Reiterer S., Petat-Dutter K., Hessel H., Berezowska S., Müllauer L., et al. Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis. Mod Pathol 2011, 24(4):585-595.
15. Nagata H., Worobec A.S., Oh C.K., Chowdhury B.A., Tannenbaum S., Suzuki Y. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci USA 1995, 92(23):10560-10564.
16. Longley B.J., Tyrrell L., Lu S.Z., Ma Y.S., Langley K., Ding T.G. Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat Genet 1996, 12(3):312-314.
17. Fritsche-Polanz R., Jordan J.H., Feix A., Sperr W.R., Sunder-Plassmann G., Valent P. Mutation analysis of C-KIT in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis. Br J Haematol 2001, 113(2):357-364.
18. Féger F., Ribadeau Dumas A., Leriche L., Valent P., Arock M. Kit and c-kit mutations in mastocytosis: a short overview with special reference to novel molecular and diagnostic concepts. Int Arch Allergy Immunol 2002, 127(2):110-114.
19. Lim K.H., Pardanani A., Butterfield J.H., Li C.Y., Tefferi A. Cytoreductive therapy in 108 adults with systemic mastocytosis: outcome analysis and response prediction during treatment with interferon-alpha, hydroxyurea, imatinib mesylate or 2-chlorodeoxyadenosine. Am J Hematol. 2009, 84(12):790-794.
20. Pardanani A., Lim K.H., Lasho T.L., Finke C., McClure R.F., Li C.Y., et al. Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies. Blood 2009, 114(18):3769-3772.