B-cell activating factor genetic variants in lymphomagenesis associated with primary Sjogren's syndrome

Journal of Autoimmunity

Volumn 51, Issue , 2014, Pages 89-98

  Nezos, Adrianos ^a   Papageorgiou, Aristea ^a   Fragoulis, George ^a   Ioakeimidis, Dimitrios ^b   Koutsilieris, Michael ^a   Tzioufas, Athanasios G ^a   Moutsopoulos, Haralampos M ^a   Voulgarelis, Michael ^a   Mavragani, Clio P ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b G GENNIMATAS GENERAL HOSPITAL   (Greece)

Author keywords

B lymphocyte activator factor (BAFF); Genetics; Lymphoma; Primary sjogren's syndrome (SS); Single nucleotide polymorphisms (SNPs)

Indexed keywords

B CELL ACTIVATING FACTOR; GENOMIC DNA;

ARTICLE; B CELL LYMPHOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA EXTRACTION; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SJOEGREN SYNDROME; ALLELE; CASE CONTROL STUDY; CELL TRANSFORMATION; COMPLICATION; GENE LOCUS; GENE ORDER; GENETICS; LYMPHOMA; SJOGREN'S SYNDROME;

ALLELES; B-CELL ACTIVATING FACTOR; CASE-CONTROL STUDIES; CELL TRANSFORMATION, NEOPLASTIC; GENE FREQUENCY; GENE ORDER; GENETIC LOCI; GENETIC VARIATION; GENOTYPE; HAPLOTYPES; HUMANS; LYMPHOMA; POLYMORPHISM, SINGLE NUCLEOTIDE; SJOGREN'S SYNDROME;

EID: 84901271891     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2013.04.005     Document Type: Article

References (40)

1. Mavragani C.P., Moutsopoulos H.M. The geoepidemiology of Sjogren's syndrome. Autoimmunity Reviews 2010 Mar, 9(5):A305-A310.
2. Tzioufas A.G., Vlachoyiannopoulos P.G. Sjogren's syndrome: an update on clinical, basic and diagnostic therapeutic aspects. Journal of Autoimmunity 2012 Aug, 39(1-2):1-3.
3. Mackay F., Groom J.R., Tangye S.G. An important role for B-cell activation factor and B cells in the pathogenesis of Sjogren's syndrome. Current Opinion in Rheumatology 2007 Sep, 19(5):406-413.
4. Varin M.M., Le Pottier L., Youinou P., Saulep D., Mackay F., Pers J.O. B-cell tolerance breakdown in Sjogren's syndrome: focus on BAFF. Autoimmunity Reviews 2010 Jul, 9(9):604-608.
5. Skopouli F.N., Dafni U., Ioannidis J.P., Moutsopoulos H.M. Clinical evolution, and morbidity and mortality of primary Sjogren's syndrome. Seminars in Arthritis and Rheumatism 2000 Apr, 29(5):296-304.
6. Voulgarelis M., Dafni U.G., Isenberg D.A., Moutsopoulos H.M. Malignant lymphoma in primary Sjogren's syndrome: a multicenter, retrospective, clinical study by the European Concerted Action on Sjogren's Syndrome. Arthritis and Rheumatism 1999 Aug, 42(8):1765-1772.
7. Ioannidis J.P., Vassiliou V.A., Moutsopoulos H.M. Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjogren's syndrome. Arthritis and Rheumatism 2002 Mar, 46(3):741-747.
8. Zintzaras E., Voulgarelis M., Moutsopoulos H.M. The risk of lymphoma development in autoimmune diseases: a meta-analysis. Archives of Internal Medicine 2005 Nov 14, 165(20):2337-2344.
9. Smedby K.E., Hjalgrim H., Askling J., Chang E.T., Gregersen H., Porwit-MacDonald A., et al. Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype. Journal of the National Cancer Institute 2006 Jan 4, 98(1):51-60.
10. Theander E., Henriksson G., Ljungberg O., Mandl T., Manthorpe R., Jacobsson L.T. Lymphoma and other malignancies in primary Sjogren's syndrome: a cohort study on cancer incidence and lymphoma predictors. Annals of the Rheumatic Diseases 2006 Jun, 65(6):796-803.
11. Voulgarelis M., Ziakas P.D., Papageorgiou A., Baimpa E., Tzioufas A.G., Moutsopoulos H.M. Prognosis and outcome of non-Hodgkin lymphoma in primary Sjogren's syndrome. Medicine (Baltimore) 2012 Jan, 91(1):1-9.
12. Mariette X. Lymphomas complicating Sjogren's syndrome and hepatitis C virus infection may share a common pathogenesis: chronic stimulation of rheumatoid factor B cells. Annals of the Rheumatic Diseases 2001 Nov, 60(11):1007-1010.
13. Pisa E.K., Pisa P., Kang H.I., Fox R.I. High frequency of t(14;18) translocation in salivary gland lymphomas from Sjogren's syndrome patients. Journal of Experimental Medicine 1991 Nov 1, 174(5):1245-1250.
14. Tapinos N.I., Polihronis M., Moutsopoulos H.M. Lymphoma development in Sjogren's syndrome: novel p53 mutations. Arthritis and Rheumatism 1999 Jul, 42(7):1466-1472.
15. Ferrer G., Hodgson K., Montserrat E., Moreno C. Bcell activator factor and a proliferation-inducing ligand at the cross-road of chronic lymphocytic leukemia and autoimmunity. Leukemia & Lymphoma 2009 Jul, 50(7):1075-1082.
16. Rothman N., Skibola C.F., Wang S.S., Morgan G., Lan Q., Smith M.T., et al. Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. Lancet Oncology 2006 Jan, 7(1):27-38.
17. Juszczynski P., Kalinka E., Bienvenu J., Woszczek G., Borowiec M., Robak T., et al. Human leukocyte antigens class II and tumor necrosis factor genetic polymorphisms are independent predictors of non-Hodgkin lymphoma outcome. Blood 2002 Oct 15, 100(8):3037-3040.
18. Demeter J., Porzsolt F., Ramisch S., Schmidt D., Schmid M., Messer G. Polymorphism of the tumour necrosis factor-alpha and lymphotoxin-alpha genes in chronic lymphocytic leukaemia. British Journal of Haematology 1997 Apr, 97(1):107-112.
19. Novak A.J., Bram R.J., Kay N.E., Jelinek D.F. Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival. Blood 2002 Oct 15, 100(8):2973-2979.
20. Ohmatsu H., Sugaya M., Miyagaki T., Suga H., Fujita H., Asano Y., et al. BAFF levels are increased in lesional skin and sera in patients with cutaneous T-cell lymphoma. The British Journal of Dermatology 2012 Aug, 167(2):359-367.
21. Lavie F., Miceli-Richard C., Quillard J., Roux S., Leclerc P., Mariette X. Expression of BAFF (BLyS) in T cells infiltrating labial salivary glands from patients with Sjogren's syndrome. The Journal of Pathology 2004 Apr, 202(4):496-502.
22. Baek A., Park H.J., Na S.J., Shim D.S., Moon J.S., Yang Y., et al. The expression of BAFF in the muscles of patients with dermatomyositis. Journal of Neuroimmunology 2012 Aug 15, 249(1-2):96-100.
23. Novak A.J., Grote D.M., Ziesmer S.C., Kline M.P., Manske M.K., Slager S., et al. Elevated serum B-lymphocyte stimulator levels in patients with familial lymphoproliferative disorders. Journal of Clinical Oncology 2006 Feb 20, 24(6):983-987.
24. Zhai K., Tian X., Wu C., Lu N., Chang J., Huang L., et al. Cytokine BAFF gene variation is associated with survival of patients with T-cell lymphomas. Clin Cancer Research 2012 Apr 15, 18(8):2250-2256.
25. Novak A.J., Slager S.L., Fredericksen Z.S., Wang A.H., Manske M.M., Ziesmer S., et al. Genetic variation in B-cell-activating factor is associated with an increased risk of developing B-cell non-Hodgkin lymphoma. Cancer Research 2009 May 15, 69(10):4217-4224.
26. Hildebrand J.M., Luo Z., Manske M.K., Price-Troska T., Ziesmer S.C., Lin W., et al. ABAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling. Journal of Experimental Medicine 2010 Nov 22, 207(12):2569-2579.
27. Kawasaki A., Tsuchiya N., Fukazawa T., Hashimoto H., Tokunaga K. Analysis on the association of human BLYS (BAFF, TNFSF13B) polymorphisms with systemic lupus erythematosus and rheumatoid arthritis. Genes Immunity 2002 Nov, 3(7):424-429.
28. Gottenberg J.E., Sellam J., Ittah M., Lavie F., Proust A., Zouali H., et al. No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjogren's syndrome. Arthritis Research & Therapy 2006, 8(1):R30.
29. Nossent J.C., Lester S., Zahra D., Mackay C.R., Rischmueller M. Polymorphism in the 5' regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome. Rheumatology (Oxford, England) 2008 Sep, 47(9):1311-1316.
30. Li Z., Zhang Z., He Z., Tang W., Li T., Zeng Z., et al. Apartition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis. Cell Research 2009 Apr, 19(4):519-523. http://analysis.bio-x.cn.
31. Sole X., Guino E., Valls J., Iniesta R., Moreno V. SNPStats: a web tool for the analysis of association studies. Bioinformatics 2006 Aug 1, 22(15):1928-1929.
32. Santiuste I., Buelta L., Iglesias M., Genre F., Mazorra F., Izui S., et al. B-cell overexpression of Bcl-2 cooperates with p21 deficiency for the induction of autoimmunity and lymphomas. Journal of Autoimmunity 2010 Dec, 35(4):316-324.
33. Theander E., Vasaitis L., Baecklund E., Nordmark G., Warfvinge G., Liedholm R., et al. Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjogren's syndrome. Annals of the Rheumatic Diseases 2011 Aug, 70(8):1363-1368.
34. Manoussakis M.N., Boiu S., Korkolopoulou P., Kapsogeorgou E.K., Kavantzas N., Ziakas P., et al. Rates of infiltration by macrophages and dendritic cells and expression of interleukin-18 and interleukin-12 in the chronic inflammatory lesions of Sjogren's syndrome: correlation with certain features of immune hyperactivity and factors associated with high risk of lymphoma development. Arthritis and Rheumatism 2007 Dec, 56(12):3977-3988.
35. Cornec D., Devauchelle-Pensec V., Tobon G.J., Pers J.O., Jousse-Joulin S., Saraux A. Bcells in Sjogren's syndrome: from pathophysiology to diagnosis and treatment. Journal of Autoimmunity Sep 2012, 39(3):161-167.
36. Lahiri A., Pochard P., Le Pottier L., Tobon G.J., Bendaoud B., Youinou P., et al. The complexity of the BAFF TNF-family members: implications for autoimmunity. Journal of Autoimmunity 2012 Sep, 39(3):189-198.
37. Mackay F., Woodcock S.A., Lawton P., Ambrose C., Baetscher M., Schneider P., et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. Journal of Experimental Medicine 1999 Dec 6, 190(11):1697-1710.
38. Batten M., Fletcher C., Ng L.G., Groom J., Wheway J., Laabi Y., et al. TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. Journal of Immunology 2004 Jan 15, 172(2):812-822.
39. Quartuccio L., Salvin S., Fabris M., Maset M., Pontarini E., Isola M., et al. BLyS upregulation in Sjogren's syndrome associated with lymphoproliferative disorders, higher ESSDAI score and B-cell clonal expansion in the salivary glands. Rheumatology (Oxford, England) 2012 Aug 9.
40. Luster T.A., Mukherjee I., Carrell J.A., Cho Y.H., Gill J., Kelly L., et al. Fusion toxin BLyS-Gelonin inhibits growth of malignant human B cell lines invitro and invivo. PloS ONE 2012, 7(10):e47361.