Authentic bosutinib inhibits triiodothyronine transport by monocarboxylate transporter 8

Thyroid

Volumn 24, Issue 5, 2014, Pages 926-927

  Braun, Doreen ^a   Schweizer, Ulrich ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BOSUTINIB; LEVOTHYROXINE; LIOTHYRONINE; MONOCARBOXYLATE TRANSPORTER 8; THYROTROPIN; AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; ISOPROTEIN; MONOCARBOXYLATE TRANSPORTER; NITRILE; QUINOLINE DERIVATIVE;

CELL MEMBRANE; CLINICAL OBSERVATION; CRYSTAL STRUCTURE; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IC 50; LETTER; MDCK CELL LINE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPARATIVE STUDY; DOG; DRUG EFFECTS; ISOMERISM; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANILINE COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; DOGS; ISOMERISM; MADIN DARBY CANINE KIDNEY CELLS; MEMBRANE TRANSPORT MODULATORS; MONOCARBOXYLIC ACID TRANSPORTERS; NITRILES; PROTEIN ISOFORMS; QUINOLINES; TRIIODOTHYRONINE;

EID: 84901255335     PISSN: 10507256     EISSN: 15579077     Source Type: Journal    
DOI: 10.1089/thy.2013.0660     Document Type: Letter

References (3)

1. Braun D, Kim TD, le Coutre P, Köhrle J, Hershman JM, Schweizer U 2012 Tyrosine kinase inhibitors noncompetitively inhibit MCT8-mediated iodothyronine transport. J Clin Endocrinol Metab 97:E100-E105.
2. Levinson NM, Boxer SG 2012 Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain. PLoS One 7:e29828
3. Halford B 2012 Bosutinib buyer beware. Molecule mix-up: The wrong isomer has been sold under the name of the cancer-fighting compound. In: Chemical and Engineering News. May 11.