Association analysis of BMD-associated SNPs with knee osteoarthritis

Journal of Bone and Mineral Research

Volumn 29, Issue 6, 2014, Pages 1373-1379

  Yerges Armstrong, Laura M ^a   Yau, Michelle S ^a   Liu, Youfang ^b   Krishnan, Subha ^c   Renner, Jordan B ^b,d   Eaton, Charles B ^e,f   Kwoh, C Kent ^g   Nevitt, Michael C ^h   Duggan, David J ^c   Mitchell, Braxton D ^a,i   Jordan, Joanne M ^b,d   Hochberg, Marc C ^a   Jackson, Rebecca D ^j  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c Translational Genomic Research Institute   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e BROWN UNIVERSITY   (United States)

^f BROWN UNIVERSITY   (United States)

^g UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ BALTIMORE VA MEDICAL CENTER   (United States)

^j OHIO STATE UNIVERSITY   (United States)

more..

Author keywords

GENETIC RESEARCH; HUMAN ASSOCIATION STUDIES; OSTEOARTHRITIS

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5;

ADULT; AGE; AGED; ALLELE; ARTICLE; BODY MASS; BONE DENSITY; CAUCASIAN; CONTROLLED STUDY; DISEASE CLASSIFICATION; FEMALE; FEMUR NECK; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC CODE; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HIP; HUMAN; JOINT CAVITY; KELLGREN LAWRENCE GRADE; KNEE OSTEOARTHRITIS; KNEE RADIOGRAPHY; LIN7C GENE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5 GENE; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OSTEOPHYTE; RISK FACTOR; SEX; SINGLE NUCLEOTIDE POLYMORPHISM; SP7 GENE; TXNDC3 GENE; GENETIC PREDISPOSITION; GENETICS; META ANALYSIS (TOPIC);

AGED; BONE DENSITY; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; META-ANALYSIS AS TOPIC; MIDDLE AGED; OSTEOARTHRITIS, KNEE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84901249534     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2160     Document Type: Article

References (27)

1. Lane NE, Brandt K, Hawker G, et al. OARSI-FDA initiative: defining the disease state of osteoarthritis. Osteoarthritis Cartilage. 2011; 19 (5): 478-82.
2. Bozic KJ, Stacey B, Berger A, Sadosky A, Oster G., Resource utilization and costs before and after total joint arthroplasty. BMC Health Serv Res. 2012; 12: 73.
3. Murphy L, Schwartz TA, Helmick CG, et al. Lifetime risk of symptomatic knee osteoarthritis. Arthritis Rheum. 2008; 59 (9): 1207-13.
4. Zhang Y, Jordan JM., Epidemiology of osteoarthritis. Clin Geriatr Med. 2010; 26 (3): 355-69.
5. Buckland-Wright C., Subchondral bone changes in hand and knee osteoarthritis detected by radiography. Osteoarthritis Cartilage. 2004; 12 (Suppl A): S10-9.
6. Nevitt MC, Zhang Y, Javaid MK, et al. High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study. Ann Rheum Dis. 2010; 69 (1): 163-8.
7. Sowers M, Lachance L, Jamadar D, et al. The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women. Arthritis Rheum. 1999; 42 (3): 483-9.
8. Bergink AP, Uitterlinden AG, Van Leeuwen JP, Hofman A, Verhaar JA, Pols HA., Bone mineral density and vertebral fracture history are associated with incident and progressive radiographic knee osteoarthritis in elderly men and women: the Rotterdam Study. Bone. 2005; 37 (4): 446-56.
9. Zhang Y, Hannan MT, Chaisson CE, et al. Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study. J Rheumatol. 2000; 27 (4): 1032-7.
10. Hochberg MC, Lethbridge-Cejku M, Tobin JD., Bone mineral density and osteoarthritis: data from the Baltimore Longitudinal Study of Aging. Osteoarthritis Cartilage. 2004; 12 (Suppl A): S45-8.
11. Estrada K, Styrkarsdottir U, Evangelou E, et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet. 2012; 44 (5): 491-501.
12. Rivadeneira F, Styrkarsdottir U, Estrada K, et al. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet. 2009; 41 (11): 1199-206.
13. Jordan JM, Helmick CG, Renner JB, et al. Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project. J Rheumatol. 2007; 34 (1): 172-80.
14. Willer CJ, Li Y, Abecasis GR., METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010; 26 (17): 2190-1.
15. Looker AC, Beck TJ, Orwoll ES., Does body size account for gender differences in femur bone density and geometry ? J Bone Miner Res. 2001; 16 (7): 1291-9.
16. Lynch JA, Parimi N, Chaganti RK, Nevitt MC, Lane NE., The association of proximal femoral shape and incident radiographic hip OA in elderly women. Osteoarthritis Cartilage. 2009; 17 (10): 1313-8.
17. Waarsing JH, Rozendaal RM, Verhaar JA, Bierma-Zeinstra SM, Weinans H., A statistical model of shape and density of the proximal femur in relation to radiological and clinical OA of the hip. Osteoarthritis Cartilage. 2010; 18 (6): 787-94.
18. Haverkamp DJ, Schiphof D, Bierma-Zeinstra SM, Weinans H, Waarsing JH., Variation in joint shape of osteoarthritic knees. Arthritis Rheum. 2011; 63 (11): 3401-7.
19. Bredbenner TL, Eliason TD, Potter RS, Mason RL, Havill LM, Nicolella DP., Statistical shape modeling describes variation in tibia and femur surface geometry between Control and Incidence groups from the osteoarthritis initiative database. J Biomech. 2010; 43 (9): 1780-6.
20. Neogi T, Bowes M, Niu J, et al. Magnetic resonance imaging-based three-dimensional bone shape of the knee predicts onset of knee osteoarthritis: data from the Osteoarthritis Initiative. Arthritis Rheum. 2013; 65: 2048-58.
21. Prieto-Alhambra D, Nogues X, Javaid MK, et al. An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW). Ann Rheum Dis. 2013; 72 (6): 911-7.
22. Loughlin J, Dowling B, Chapman K, et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A. 2004; 101 (26): 9757-62.
23. Min JL, Meulenbelt I, Riyazi N, et al. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum. 2005; 52 (4): 1077-80.
24. Lane NE, Lian K, Nevitt MC, et al. Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum. 2006; 54 (4): 1246-54.
25. Valdes AM, Loughlin J, Oene MV, et al. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum. 2007; 56 (1): 137-46.
26. Lories RJ, Boonen S, Peeters J, de Vlam K, Luyten FP., Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis. Rheumatology (Oxford). 2006; 45 (1): 113-4.
27. Kerkhof HJ, Meulenbelt I, Akune T, et al. Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage. 2011; 19 (3): 254-64.