An in vitro and in vivo evaluation of the efficacy of recombinant human liver prolidase as a catalytic bioscavenger of chemical warfare nerve agents

Drug and Chemical Toxicology

Volumn 38, Issue 1, 2015, Pages 37-43

  Rezk, Peter E ^a   Zdenka, Pierre ^a   Sabnekar, Praveena ^a   Kajih, Takwen ^a   Mata, David G ^a   Wrobel, Chester ^a   Cerasoli, Douglas M ^a   Chilukuri, Nageswararao ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Adenovirus; butyrylcholinesterase; catalytic bioscavenger; chemical warfare nerve agents; human liver prolidase; in vivo delivery

Indexed keywords

CHOLINESTERASE; CYCLOSARIN; PROLINE DIPEPTIDASE; SARIN; SOMAN; CHEMICAL WARFARE AGENT; DIPEPTIDASE; RECOMBINANT PROTEIN;

ADENOVIRIDAE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL WARFARE; CONTROLLED STUDY; ENZYME PURIFICATION; EVALUATION STUDY; GEL FILTRATION CHROMATOGRAPHY; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; ISOMER; LD 50; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; ANIMAL; BIOCATALYSIS; BLOOD; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION; GENE TRANSFER; GENE VECTOR; GENETICS; HUMAN; LD50; LIVER; METABOLISM;

ADENOVIRIDAE; ANIMALIA; MUS;

ADENOVIRIDAE; ANIMALS; BIOCATALYSIS; BUTYRYLCHOLINESTERASE; CHEMICAL WARFARE AGENTS; DIPEPTIDASES; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; HYDROLYSIS; IN VITRO TECHNIQUES; LETHAL DOSE 50; LIVER; MALE; MICE; RECOMBINANT PROTEINS;

EID: 84901225367     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480545.2014.900071     Document Type: Article

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