HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression

Oncotarget

Volumn 5, Issue 9, 2014, Pages 2596-2607

  Li, Yong ^a   Chao, Fengmei ^a   Huang, Bei ^a   Liu, Dahai ^a   Kim, Jaejik ^b   Huang, Shuang ^c,d  

^a ANHUI UNIVERSITY   (China)

^b AUGUSTA UNIVERSITY   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Breast cancer; CDH11; HOXC8; Metastasis; Transcription

Indexed keywords

CADHERIN; CADHERIN 11; HOMEOBOX C8 PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; HOXC8 PROTEIN, HUMAN; LUCIFERASE; MESSENGER RNA; OSTEOBLAST CADHERIN; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; CANCER CELL; CANCER SURVIVAL; CANCER TISSUE; CELL GROWTH; CELL INVASION; CELL MIGRATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; METASTASIS; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BREAST TUMOR; CELL MOTION; CELL PROLIFERATION; CELL TRANSFORMATION; DRUG SCREENING; ENZYME IMMUNOASSAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CADHERINS; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; LUCIFERASES; MICE; MICE, NUDE; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84901218023     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1841     Document Type: Article

References (31)

1. Gehring WJ and Hiromi Y. Homeotic genes and the homeobox. Annual review of genetics. 1986; 20:147-173.
2. He XX, Chang Y, Meng FY, Wang MY, Xie QH, Tang F, Li PY, Song YH and Lin JS. MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo. Oncogene. 2012; 31(28):3357-3369.
3. Nohata N, Hanazawa T, Kikkawa N, Mutallip M, Sakurai D, Fujimura L, Kawakami K, Chiyomaru T, Yoshino H, Enokida H, Nakagawa M, Okamoto Y and Seki N. Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). J Hum Genet. 2011; 56(8):595-601.
4. de Souza Rocha Simonini P, Breiling A, Gupta N, Malekpour M, Youns M, Omranipour R, Malekpour F, Volinia S, Croce CM, Najmabadi H, Diederichs S, Sahin O, Mayer D, Lyko F, Hoheisel JD and Riazalhosseini Y. Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells. Cancer Res. 2010; 70(22):9175-9184.
5. Alami Y, Castronovo V, Belotti D, Flagiello D and Clausse N. HOXC5 and HOXC8 expression are selectively turned on in human cervical cancer cells compared to normal keratinocytes. Biochem Biophys Res Commun. 1999; 257(3):738-745.
6. Waltregny D, Alami Y, Clausse N, de Leval J and Castronovo V. Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation. The Prostate. 2002; 50(3):162-169.
7. Li Y, Zhang M, Chen H, Dong Z, Ganapathy V, Thangaraju M and Huang S. Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis. Cancer Res. 2010; 70(20):7894-7904.
8. Lei H, Wang H, Juan AH and Ruddle FH. The identification of Hoxc8 target genes. Proc Natl Acad Sci U S A. 2005; 102(7):2420-2424.
9. Lei H, Juan AH, Kim MS and Ruddle FH. Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells. Proc Natl Acad Sci U S A. 2006; 103(27):10305-10309.
10. Nollet F, Kools P and van Roy F. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. Journal of Molecular Biology. 2000; 299(3):551-572.
11. Okazaki M, Takeshita S, Kawai S, Kikuno R, Tsujimura A, Kudo A and Amann E. Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. J Biol Chem. 1994; 269(16):12092-12098.
12. Hoffmann I and Balling R. Cloning and expression analysis of a novel mesodermally expressed cadherin. Dev Biol. 1995; 169(1):337-346.
13. Simonneau L, Kitagawa M, Suzuki S and Thiery JP. Cadherin 11 expression marks the mesenchymal phenotype: towards new functions for cadherins? Cell Adhes Commun. 1995; 3(2):115-130.
14. Sarrio D, Rodriguez-Pinilla SM, Hardisson D, Cano A, Moreno-Bueno G and Palacios J. Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res. 2008; 68(4):989-997.
15. Tomita K, van Bokhoven A, van Leenders GJ, Ruijter ET, Jansen CF, Bussemakers MJ and Schalken JA. Cadherin switching in human prostate cancer progression. Cancer Res. 2000; 60(13):3650-3654.
16. Kashima T, Kawaguchi J, Takeshita S, Kuroda M, Takanashi M, Horiuchi H, Imamura T, Ishikawa Y, Ishida T, Mori S, Machinami R and Kudo A. Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis. The American journal of pathology. 1999; 155(5):1549-1555.
17. Vider BZ, Zimber A, Chastre E, Gespach C, Halperin M, Mashiah P, Yaniv A and Gazit A. Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines. Biochem Biophys Res Commun. 2000; 272(2):513-518.
18. Pishvaian MJ, Feltes CM, Thompson P, Bussemakers MJ, Schalken JA and Byers SW. Cadherin-11 is expressed in invasive breast cancer cell lines. Cancer Res. 1999; 59(4):947-952.
19. Bussemakers MJ, Van Bokhoven A, Tomita K, Jansen CF and Schalken JA. Complex cadherin expression in human prostate cancer cells. Int J Cancer. 2000; 85(3):446-450.
20. Huang CF, Lira C, Chu K, Bilen MA, Lee YC, Ye X, Kim SM, Ortiz A, Wu FL, Logothetis CJ, Yu-Lee LY and Lin SH. Cadherin-11 increases migration and invasion of prostate cancer cells and enhances their interaction with osteoblasts. Cancer Res. 2010; 70(11):4580-4589.
21. Nieman MT, Prudoff RS, Johnson KR and Wheelock MJ. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol. 1999; 147(3):631-644.
22. Li Y, Guo Z, Chen H, Dong Z, Ding H and Huang S. HOXC8-Dependent Cadherin 11 Expression Facilitates Breast Cancer Cell Migration through Trio and Rac. Genes&Cancer. 2012.
23. Svingen T and Tonissen KF. Hox transcription factors and their elusive mammalian gene targets. Heredity. 2006; 97(2):88-96.
24. Harris T, Jimenez L, Kawachi N, Fan JB, Chen J, Belbin T, Ramnauth A, Loudig O, Keller CE, Smith R, Prystowsky MB, Schlecht NF, Segall JE and Childs G. Low-level expression of miR-375 correlates with poor outcome and metastasis while altering the invasive properties of head and neck squamous cell carcinomas. The American journal of pathology. 2012; 180(3):917-928.
25. Axlund SD, Lambert JR and Nordeen SK. HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes. Mol Cancer Res. 8(12):1643-1655.
26. Shi X, Yang X, Chen D, Chang Z and Cao X. Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling. J Biol Chem. 1999; 274(19):13711-13717.
27. Shi X, Bai S, Li L and Cao X. Hoxa-9 represses transforming growth factor-beta-induced osteopontin gene transcription. J Biol Chem. 2001; 276(1):850-855.
28. Hu Q, Lu YY, Noh H, Hong S, Dong Z, Ding HF, Su SB and Huang S. Interleukin enhancer-binding factor 3 promotes breast tumor progression by regulating sustained urokinase-type plasminogen activator expression. Oncogene. 2013; 32(34):3933-3943.
29. Chen H, Wu X, Pan ZK and Huang S. Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis. Cancer Res. 2010; 70(23):9979-9990.
30. Chen H, Zhu G, Li Y, Padia RN, Dong Z, Pan ZK, Liu K and Huang S. Extracellular signal-regulated kinase signaling pathway regulates breast cancer cell migration by maintaining slug expression. Cancer Res. 2009; 69(24):9228-9235.
31. Wang W, Chen JX, Liao R, Deng Q, Zhou JJ, Huang S and Sun P. Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol. 2002; 22(10):3389-3403.