메뉴 건너뛰기




Volumn 60, Issue 6, 2014, Pages 1127-1134

Entecavir vs. lamivudine in chronic hepatitis B patients with severe acute exacerbation and hepatic decompensation

Author keywords

Basal core promoter mutation; Hepatic encephalopathy; Hepatitis B virus; Liver related mortality; MELD scores

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; ENTECAVIR; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; CREATININE; HEPATITIS B VIRUS DNA; TELBIVUDINE; UNCLASSIFIED DRUG; VIRUS DNA; ANTIVIRUS AGENT; GUANINE;

EID: 84901192746     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.02.013     Document Type: Article
Times cited : (48)

References (42)
  • 1
    • 0030707941 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • W.M. Lee Hepatitis B virus infection N Engl J Med 337 1997 1733 1745
    • (1997) N Engl J Med , vol.337 , pp. 1733-1745
    • Lee, W.M.1
  • 2
    • 0027422748 scopus 로고
    • From hepatitis to hepatoma: Lessons from type B viral hepatitis
    • D.S. Chen From hepatitis to hepatoma: lessons from type B viral hepatitis Science 262 1993 369 370
    • (1993) Science , vol.262 , pp. 369-370
    • Chen, D.S.1
  • 3
    • 59149086601 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis B virus infection and long-term outcome under treatment
    • Y.F. Liaw Natural history of chronic hepatitis B virus infection and long-term outcome under treatment Liver Int 29 2009 100 107
    • (2009) Liver Int , vol.29 , pp. 100-107
    • Liaw, Y.F.1
  • 4
    • 0033214863 scopus 로고    scopus 로고
    • Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection
    • C.M. Lee, S.N. Lu, C.S. Changchien, C.T. Yeh, T.T. Hsu, and J.H. Tang et al. Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection Cancer 86 1999 1143 1150
    • (1999) Cancer , vol.86 , pp. 1143-1150
    • Lee, C.M.1    Lu, S.N.2    Changchien, C.S.3    Yeh, C.T.4    Hsu, T.T.5    Tang, J.H.6
  • 5
    • 0025128658 scopus 로고
    • Acute exacerbation in Chinese patients with chronic hepatitis B virus (HBV) infection. Incidence, predisposing factors and etiology
    • A.S. Lok, and C.L. Lai Acute exacerbation in Chinese patients with chronic hepatitis B virus (HBV) infection. Incidence, predisposing factors and etiology J Hepatol 10 1990 29 34
    • (1990) J Hepatol , vol.10 , pp. 29-34
    • Lok, A.S.1    Lai, C.L.2
  • 6
    • 68749088893 scopus 로고    scopus 로고
    • Severe acute exacerbation of chronic hepatitis B: A unique presentation of a common disease
    • V.W. Wong, and H.L. Chan Severe acute exacerbation of chronic hepatitis B: a unique presentation of a common disease J Gastroenterol Hepatol 24 2009 1179 1186
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 1179-1186
    • Wong, V.W.1    Chan, H.L.2
  • 7
    • 51049107683 scopus 로고    scopus 로고
    • Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2008 update
    • Y.F. Liaw, N. Leung, J.H. Kao, T. Piratvisuth, E. Gane, and K.H. Han et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update Hepatol Int 2 2008 263 283
    • (2008) Hepatol Int , vol.2 , pp. 263-283
    • Liaw, Y.F.1    Leung, N.2    Kao, J.H.3    Piratvisuth, T.4    Gane, E.5    Han, K.H.6
  • 9
    • 0036844794 scopus 로고    scopus 로고
    • Durability of lamivudine-induced HBeAg seroconversion for chronic hepatitis B patients with acute exacerbation
    • C.M. Lee, G.Y. Ong, S.N. Lu, J.H. Wang, C.A. Liao, and H.D. Tung et al. Durability of lamivudine-induced HBeAg seroconversion for chronic hepatitis B patients with acute exacerbation J Hepatol 37 2002 669 674
    • (2002) J Hepatol , vol.37 , pp. 669-674
    • Lee, C.M.1    Ong, G.Y.2    Lu, S.N.3    Wang, J.H.4    Liao, C.A.5    Tung, H.D.6
  • 10
    • 19544391413 scopus 로고    scopus 로고
    • Lamivudine for patients with chronic hepatitis B and advanced liver disease
    • Y.F. Liaw, J.J. Sung, W.C. Chow, G. Farrell, C.Z. Lee, and H. Yuen et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease N Engl J Med 351 2004 1521 1531
    • (2004) N Engl J Med , vol.351 , pp. 1521-1531
    • Liaw, Y.F.1    Sung, J.J.2    Chow, W.C.3    Farrell, G.4    Lee, C.Z.5    Yuen, H.6
  • 11
    • 84865376141 scopus 로고    scopus 로고
    • Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2012 update
    • Y.F. Liaw, J.H. Kao, T. Piratvisuth, H.L.Y. Chan, R.N. Chien, and C.J. Liu et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update Hepatol Int 6 2012 531 561
    • (2012) Hepatol Int , vol.6 , pp. 531-561
    • Liaw, Y.F.1    Kao, J.H.2    Piratvisuth, T.3    Chan, H.L.Y.4    Chien, R.N.5    Liu, C.J.6
  • 12
    • 70349240414 scopus 로고    scopus 로고
    • Chronic hepatitis B: Update 2009
    • A.S.F. Lok, and B.J. McMahon Chronic hepatitis B: update 2009 Hepatology 50 2009 1 36
    • (2009) Hepatology , vol.50 , pp. 1-36
    • Lok, A.S.F.1    McMahon, B.J.2
  • 13
    • 84862664371 scopus 로고    scopus 로고
    • Management of chronic hepatitis B virus infection
    • EASL Clinical Practice Guidelines Management of chronic hepatitis B virus infection Eur Assoc Study Liver J Hepatol 57 2012 167 185
    • (2012) Eur Assoc Study Liver J Hepatol , vol.57 , pp. 167-185
  • 14
    • 33745766453 scopus 로고    scopus 로고
    • Long-term lamivudine treatment is associated with a good maintained response in severe acute exacerbation of chronic HBeAg-negative hepatitis B
    • H.L. Chan, V.W. Wong, A.Y. Hui, S.W. Tsang, J.L. Chan, and H.Y. Chan et al. Long-term lamivudine treatment is associated with a good maintained response in severe acute exacerbation of chronic HBeAg-negative hepatitis B Antivir Ther 11 2006 465 471
    • (2006) Antivir Ther , vol.11 , pp. 465-471
    • Chan, H.L.1    Wong, V.W.2    Hui, A.Y.3    Tsang, S.W.4    Chan, J.L.5    Chan, H.Y.6
  • 15
    • 47649090775 scopus 로고    scopus 로고
    • Long-term follow-up of lamivudine treatment in patients with severe acute exacerbation of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B
    • V.W. Wong, G.L. Wong, S.W. Tsang, A.Y. Hui, A.M. Chim, and K.K. Yiu et al. Long-term follow-up of lamivudine treatment in patients with severe acute exacerbation of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B Antivir Ther 13 2008 571 579
    • (2008) Antivir Ther , vol.13 , pp. 571-579
    • Wong, V.W.1    Wong, G.L.2    Tsang, S.W.3    Hui, A.Y.4    Chim, A.M.5    Yiu, K.K.6
  • 16
    • 9144243211 scopus 로고    scopus 로고
    • Benefit of lamivudine therapy and factors associated with clinical outcome in spontaneous severe acute exacerbation of chronic hepatitis B virus infection
    • A. Tsubota, Y. Arase, Y. Suzuki, F. Suzuki, T. Hosaka, and N. Akuta et al. Benefit of lamivudine therapy and factors associated with clinical outcome in spontaneous severe acute exacerbation of chronic hepatitis B virus infection Intervirology 47 2004 335 341
    • (2004) Intervirology , vol.47 , pp. 335-341
    • Tsubota, A.1    Arase, Y.2    Suzuki, Y.3    Suzuki, F.4    Hosaka, T.5    Akuta, N.6
  • 17
    • 10744225554 scopus 로고    scopus 로고
    • Long-term safety of lamivudine treatment in patients with chronic hepatitis B
    • A.S. Lok, C.L. Lai, N. Leung, G.B. Yao, Z.Y. Cui, and E.R. Schiff et al. Long-term safety of lamivudine treatment in patients with chronic hepatitis B Gastroenterology 125 2003 1714 1722
    • (2003) Gastroenterology , vol.125 , pp. 1714-1722
    • Lok, A.S.1    Lai, C.L.2    Leung, N.3    Yao, G.B.4    Cui, Z.Y.5    Schiff, E.R.6
  • 18
    • 35649020315 scopus 로고    scopus 로고
    • Entecavir therapy for up to 96 weeks in patients with HBeAg-positive chronic hepatitis B
    • R.G. Gish, A.S. Lok, T.T. Chang, R.A. de Man, A. Gadano, and J. Sollano et al. Entecavir therapy for up to 96 weeks in patients with HBeAg-positive chronic hepatitis B Gastroenterology 33 2007 1437 1444
    • (2007) Gastroenterology , vol.33 , pp. 1437-1444
    • Gish, R.G.1    Lok, A.S.2    Chang, T.T.3    De Man, R.A.4    Gadano, A.5    Sollano, J.6
  • 19
    • 75449107726 scopus 로고    scopus 로고
    • Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B
    • T.T. Chang, C.L. Lai, S.K. Yoon, S.S. Lee, H.S. Coelho, and F.J. Carrilho et al. Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B Hepatology 51 2010 422 430
    • (2010) Hepatology , vol.51 , pp. 422-430
    • Chang, T.T.1    Lai, C.L.2    Yoon, S.K.3    Lee, S.S.4    Coelho, H.S.5    Carrilho, F.J.6
  • 20
    • 66149115173 scopus 로고    scopus 로고
    • Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naive patients is rare through 5 years of therapy
    • D.J. Tenney, R.E. Rose, C.J. Baldick, K.A. Pokornowski, B.J. Eggers, and J. Fang et al. Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naive patients is rare through 5 years of therapy Hepatology 49 2009 1503 1514
    • (2009) Hepatology , vol.49 , pp. 1503-1514
    • Tenney, D.J.1    Rose, R.E.2    Baldick, C.J.3    Pokornowski, K.A.4    Eggers, B.J.5    Fang, J.6
  • 21
    • 73149085984 scopus 로고    scopus 로고
    • Severe lactic acidosis during treatment of chronic hepatitis B with entecavir in patients with impaired liver function
    • C.M. Lange, J. Bojunga, W.P. Hofmann, K. Wunder, U. Mihm, and S. Zeuzem et al. Severe lactic acidosis during treatment of chronic hepatitis B with entecavir in patients with impaired liver function Hepatology 50 2009 2001 2006
    • (2009) Hepatology , vol.50 , pp. 2001-2006
    • Lange, C.M.1    Bojunga, J.2    Hofmann, W.P.3    Wunder, K.4    Mihm, U.5    Zeuzem, S.6
  • 22
    • 78751590984 scopus 로고    scopus 로고
    • Entecavir treatment in patients with severe acute exacerbation of chronic hepatitis B
    • V.W. Wong, G.L. Wong, K.K. Yiu, A.M. Chim, S.H. Chu, and H.Y. Chan et al. Entecavir treatment in patients with severe acute exacerbation of chronic hepatitis B J Hepatol 54 2011 236 242
    • (2011) J Hepatol , vol.54 , pp. 236-242
    • Wong, V.W.1    Wong, G.L.2    Yiu, K.K.3    Chim, A.M.4    Chu, S.H.5    Chan, H.Y.6
  • 23
    • 84861697827 scopus 로고    scopus 로고
    • Entecavir versus lamivudine in the treatment of chronic hepatitis B patients with hepatic decompensation
    • Y.C. Hsu, L.R. Mo, C.Y. Chang, D.S. Perng, C.H. Tseng, and G.H. Lo et al. Entecavir versus lamivudine in the treatment of chronic hepatitis B patients with hepatic decompensation Antivir Ther 17 2012 605 612
    • (2012) Antivir Ther , vol.17 , pp. 605-612
    • Hsu, Y.C.1    Mo, L.R.2    Chang, C.Y.3    Perng, D.S.4    Tseng, C.H.5    Lo, G.H.6
  • 24
    • 0037336224 scopus 로고    scopus 로고
    • The effect of lamivudine therapy in hepatic decompensation during acute exacerbation of chronic hepatitis B
    • R.N. Chien, C.H. Lin, and Y.F. Liaw The effect of lamivudine therapy in hepatic decompensation during acute exacerbation of chronic hepatitis B J Hepatol 38 2003 322 327
    • (2003) J Hepatol , vol.38 , pp. 322-327
    • Chien, R.N.1    Lin, C.H.2    Liaw, Y.F.3
  • 25
    • 0021816456 scopus 로고
    • Hepatic decompensation associated with hepatitis B e antigen clearance in chronic type B hepatitis
    • I.S. Sheen, Y.F. Liaw, and D.I. Tai et al. Hepatic decompensation associated with hepatitis B e antigen clearance in chronic type B hepatitis Gasteroenterology 89 1985 732 735
    • (1985) Gasteroenterology , vol.89 , pp. 732-735
    • Sheen, I.S.1    Liaw, Y.F.2    Tai, D.I.3
  • 26
    • 77952742728 scopus 로고    scopus 로고
    • Hepatitis B virus DNA level predicts hepatic decompensation in patients with acute exacerbation of chronic hepatitis B
    • W.J. Jeng, I.S. Sheen, and Y.F. Liaw Hepatitis B virus DNA level predicts hepatic decompensation in patients with acute exacerbation of chronic hepatitis B Clin Gastroenterol Hepatol 8 2010 541 545
    • (2010) Clin Gastroenterol Hepatol , vol.8 , pp. 541-545
    • Jeng, W.J.1    Sheen, I.S.2    Liaw, Y.F.3
  • 27
    • 59749098468 scopus 로고    scopus 로고
    • Acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)
    • S.K. Sarin, A. Kumar, J.A. Almeida, Y.K. Chawla, S.T. Fan, and H. Garg et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL) Hepatol Int 3 2009 269 282
    • (2009) Hepatol Int , vol.3 , pp. 269-282
    • Sarin, S.K.1    Kumar, A.2    Almeida, J.A.3    Chawla, Y.K.4    Fan, S.T.5    Garg, H.6
  • 28
    • 4344678961 scopus 로고    scopus 로고
    • Comparison of clinical outcome between patients continuing and discontinuing lamivudine therapy after biochemical breakthrough of YMDD mutants
    • C.H. Chen, C.M. Lee, S.N. Lu, J.H. Wang, H.D. Tung, and C.H. Hung et al. Comparison of clinical outcome between patients continuing and discontinuing lamivudine therapy after biochemical breakthrough of YMDD mutants J Hepatol 41 2004 454 461
    • (2004) J Hepatol , vol.41 , pp. 454-461
    • Chen, C.H.1    Lee, C.M.2    Lu, S.N.3    Wang, J.H.4    Tung, H.D.5    Hung, C.H.6
  • 29
    • 35649014367 scopus 로고    scopus 로고
    • Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients
    • C.H. Chen, C.H. Hung, C.M. Lee, T.H. Hu, J.H. Wang, and J.C. Wang et al. Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients Gastroenterology 133 2007 1466 1474
    • (2007) Gastroenterology , vol.133 , pp. 1466-1474
    • Chen, C.H.1    Hung, C.H.2    Lee, C.M.3    Hu, T.H.4    Wang, J.H.5    Wang, J.C.6
  • 30
    • 30744468144 scopus 로고    scopus 로고
    • Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan
    • C.H. Chen, C.M. Lee, S.N. Lu, C.S. Changchien, H.L. Eng, and C.M. Huang et al. Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan J Clin Microbiol 43 2005 6000 6006
    • (2005) J Clin Microbiol , vol.43 , pp. 6000-6006
    • Chen, C.H.1    Lee, C.M.2    Lu, S.N.3    Changchien, C.S.4    Eng, H.L.5    Huang, C.M.6
  • 31
    • 28844435348 scopus 로고    scopus 로고
    • Comparison of sequence changes of precore and core promoter regions in HBeAg-positive chronic hepatitis B patients with and without HBeAg clearance in lamivudine therapy
    • C.H. Chen, C.M. Lee, S.N. Lu, C.S. Changchien, J.C. Wang, and J.H. Wang et al. Comparison of sequence changes of precore and core promoter regions in HBeAg-positive chronic hepatitis B patients with and without HBeAg clearance in lamivudine therapy J Hepatol 44 2006 76 82
    • (2006) J Hepatol , vol.44 , pp. 76-82
    • Chen, C.H.1    Lee, C.M.2    Lu, S.N.3    Changchien, C.S.4    Wang, J.C.5    Wang, J.H.6
  • 32
    • 34447309567 scopus 로고    scopus 로고
    • Clinical significance and evolution of core promoter and precore mutations in HBeAg-positive patients with HBV genotype B and C: A longitudinal study
    • C.H. Chen, C.M. Lee, C.H. Hung, T.H. Hu, J.H. Wang, and J.C. Wang et al. Clinical significance and evolution of core promoter and precore mutations in HBeAg-positive patients with HBV genotype B and C: a longitudinal study Liver Int 27 2007 806 815
    • (2007) Liver Int , vol.27 , pp. 806-815
    • Chen, C.H.1    Lee, C.M.2    Hung, C.H.3    Hu, T.H.4    Wang, J.H.5    Wang, J.C.6
  • 33
    • 0037260187 scopus 로고    scopus 로고
    • Prevalence and clinical implications of hepatitis B virus genotypes in southern Taiwan
    • C.M. Lee, C.H. Chen, S.N. Lu, H.D. Tung, W.J. Chou, and J.H. Wang et al. Prevalence and clinical implications of hepatitis B virus genotypes in southern Taiwan Scand J Gastroenterol 1 2003 95 101
    • (2003) Scand J Gastroenterol , vol.1 , pp. 95-101
    • Lee, C.M.1    Chen, C.H.2    Lu, S.N.3    Tung, H.D.4    Chou, W.J.5    Wang, J.H.6
  • 34
    • 84865470803 scopus 로고    scopus 로고
    • Nucleoside analogues improve the short-term and long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure
    • T. Chen, Y. He, X. Liu, Z. Yan, K. Wang, and H. Liu et al. Nucleoside analogues improve the short-term and long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure Clin Exp Med 12 2012 159 164
    • (2012) Clin Exp Med , vol.12 , pp. 159-164
    • Chen, T.1    He, Y.2    Liu, X.3    Yan, Z.4    Wang, K.5    Liu, H.6
  • 35
    • 77954423599 scopus 로고    scopus 로고
    • Nucleoside analogue can improve the long-term prognosis of patients with hepatitis B virus infection-associated acute on chronic liver failure
    • Y.L. Cui, F. Yan, Y.B. Wang, X.Q. Song, L. Liu, and X.Z. Lei et al. Nucleoside analogue can improve the long-term prognosis of patients with hepatitis B virus infection-associated acute on chronic liver failure Dig Dis Sci 55 2010 2373 2380
    • (2010) Dig Dis Sci , vol.55 , pp. 2373-2380
    • Cui, Y.L.1    Yan, F.2    Wang, Y.B.3    Song, X.Q.4    Liu, L.5    Lei, X.Z.6
  • 36
    • 57349095400 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate vs adefovir dipivoxil for chronic hepatitis B
    • P. Marcellin, E.J. Heathcote, M. Buti, E. Gane, R.A. de Man, and Z. Krastev et al. Tenofovir disoproxil fumarate vs. adefovir dipivoxil for chronic hepatitis B N Engl J Med 359 2008 2442 2455
    • (2008) N Engl J Med , vol.359 , pp. 2442-2455
    • Marcellin, P.1    Heathcote, E.J.2    Buti, M.3    Gane, E.4    De Man, R.A.5    Krastev, Z.6
  • 37
    • 79952211991 scopus 로고    scopus 로고
    • Tenofovir improves the outcome in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure
    • H. Garg, S.K. Sarin, M. Kumar, V. Garg, B.C. Sharma, and A. Kumar Tenofovir improves the outcome in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure Hepatology 53 2011 774 780
    • (2011) Hepatology , vol.53 , pp. 774-780
    • Garg, H.1    Sarin, S.K.2    Kumar, M.3    Garg, V.4    Sharma, B.C.5    Kumar, A.6
  • 39
    • 77649226306 scopus 로고    scopus 로고
    • Influential factors of prognosis in lamivudine treatment for patients with acute-on-chronic hepatitis B liver failure
    • L.J. Sun, J.W. Yu, Y.H. Zhao, P. Kang, and S.C. Li Influential factors of prognosis in lamivudine treatment for patients with acute-on-chronic hepatitis B liver failure J Gastroenterol Hepatol 25 2010 583 590
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 583-590
    • Sun, L.J.1    Yu, J.W.2    Zhao, Y.H.3    Kang, P.4    Li, S.C.5
  • 40
    • 21844433214 scopus 로고    scopus 로고
    • Determinants of early mortality and benefits of lamivudine therapy in patients with hepatitis B virus-related decompensated liver cirrhosis
    • P.L. Tseng, S.N. Lu, H.D. Tung, J.H. Wang, C.S. Changchien, and C.M. Lee Determinants of early mortality and benefits of lamivudine therapy in patients with hepatitis B virus-related decompensated liver cirrhosis J Viral Hepat 12 2005 386 392
    • (2005) J Viral Hepat , vol.12 , pp. 386-392
    • Tseng, P.L.1    Lu, S.N.2    Tung, H.D.3    Wang, J.H.4    Changchien, C.S.5    Lee, C.M.6
  • 41
    • 0242298194 scopus 로고    scopus 로고
    • Distribution of hepatitis B viral genotypes and mutations in the core promoter and precore regions in acute forms of liver disease in patients from Chiba, Japan
    • T. Imamura, O. Yokosuka, T. Kurihara, T. Kanda, K. Fukai, and F. Imazeki et al. Distribution of hepatitis B viral genotypes and mutations in the core promoter and precore regions in acute forms of liver disease in patients from Chiba, Japan Gut 52 2003 1630 1637
    • (2003) Gut , vol.52 , pp. 1630-1637
    • Imamura, T.1    Yokosuka, O.2    Kurihara, T.3    Kanda, T.4    Fukai, K.5    Imazeki, F.6
  • 42
    • 0032869876 scopus 로고    scopus 로고
    • Pretherapy alanine transaminase level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B. Asian Hepatitis Lamivudine Trial Group
    • R.N. Chien, Y.F. Liaw, and M. Atkins Pretherapy alanine transaminase level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B. Asian Hepatitis Lamivudine Trial Group Hepatology 30 1999 770 774
    • (1999) Hepatology , vol.30 , pp. 770-774
    • Chien, R.N.1    Liaw, Y.F.2    Atkins, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.