Branched Chain Amino acids are associated with muscle mass in functionally limited older adults

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 69, Issue 6, 2014, Pages 717-724

  Lustgarten, Michael S ^a   Price, Lori Lyn ^b   Chale, Angela ^a   Phillips, Edward M ^a   Fielding, Roger A ^a  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Biomarkers; Inflammation; Insulin resistance; Metabolomics; Muscle

Indexed keywords

BIOLOGICAL MARKER; BRANCHED CHAIN AMINO ACID;

AGED; AGING; ARTICLE; BODY COMPOSITION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENERGY METABOLISM; FEMALE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; MALE; METABOLISM; METABOLOMICS; METABOLOMICS.; METHODOLOGY; MOTOR ACTIVITY; MUSCLE; PATHOPHYSIOLOGY; PHOTON ABSORPTIOMETRY; PHYSIOLOGY; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; VERY ELDERLY;

BIOMARKERS; INFLAMMATION; INSULIN RESISTANCE; METABOLOMICS.; MUSCLE;

ABSORPTIOMETRY, PHOTON; AGED; AGED, 80 AND OVER; AGING; AMINO ACIDS, BRANCHED-CHAIN; BODY COMPOSITION; DOUBLE-BLIND METHOD; ENERGY METABOLISM; FEMALE; HUMANS; INFLAMMATION; INSULIN RESISTANCE; MALE; METABOLOMICS; MOTOR ACTIVITY; MUSCLE, SKELETAL; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84901060271     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glt152     Document Type: Article

References (40)

1. Heymsfield SB, Smith R, Aulet M, et al. Appendicular skeletal musclemass: measurement by dual-photon absorptiometry. Am J Clin Nutr.199052:214-218.
2. Hughes VA, Frontera WR, Roubenoff R, Evans WJ, Singh MA.Longitudinal changes in body composition in older men and women:role of body weight change and physical activity. Am J Clin Nutr.200276:473-481.
3. Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiologyof sarcopenia among the elderly in New Mexico. Am J Epidemiol.1998147:755-763.
4. Park SW, Goodpaster BH, Lee JS, et al. Health, Aging, and BodyComposition Study. Excessive loss of skeletal muscle mass in olderadults with type 2 diabetes. Diabetes Care 200932:1993-1997.
5. Reaven GM. Banting lecture 1988. Role of insulin resistance in humandisease. Diabetes. 198837:1595-1607.
6. Goodman MN. Tumor necrosis factor induces skeletal muscle proteinbreakdown in rats. Am J Physiol. 1991260(5 Pt 1):E727-E730.
7. Goodman MN. Interleukin-6 induces skeletal muscle protein breakdownin rats. Proc Soc Exp Biol Med. 1994205:182-185.
8. Visser M, Pahor M, Taaffe DR, et al. Relationship of interleukin-6 andtumor necrosis factor-alpha with muscle mass and muscle strength inelderly men and women: the Health ABC Study. J Gerontol A Biol SciMed Sci. 200257:M326-M332.
9. Fiehn O. Metabolomics-the link between genotypes and phenotypes.Plant Mol Biol. 200248:155-171.
10. Magnusson M, Lewis GD, Ericson U, et al. A diabetes-predictiveamino acid score and future cardiovascular disease. Eur Heart J.201334:1982-1989.
11. Yang J, Xu G, Zheng Y, et al. Diagnosis of liver cancer using HPLCbasedmetabonomics avoiding false-positive result from hepatitis andhepatocirrhosis diseases. J Chromatogr B Analyt Technol Biomed LifeSci. 2004813:59-65.
12. Ha CY, Kim JY, Paik JK, et al. The association of specific metabolitesof lipid metabolism with markers of oxidative stress, inflammationand arterial stiffness in men with newly diagnosed type 2 diabetes.Clin Endocrinol (Oxf). 201276:674-682.
13. Newgard CB, An J, Bain JR, et al. A branched-chain amino acidrelatedmetabolic signature that differentiates obese and lean humansand contributes to insulin resistance. Cell Metab. 20099:311-326.
14. Wu T, Xie C, Han J, et al. Metabolic disturbances associated withsystemic lupus erythematosus. PLoS One. 20127:e37210.
15. Chal?A, Cloutier GJ, Hau C, Phillips EM, Dallal GE, Fielding RA.Efficacy of whey protein supplementation on resistance exerciseinducedchanges in lean mass, muscle strength, and physical functionin mobility-limited older adults. J Gerontol A Biol Sci Med Sci.201368:682-690.
16. Frontera WR, Reid KF, Phillips EM, et al. Muscle fiber size andfunction in elderly humans: a longitudinal study. J Appl Physiol.2008105:637-642.
17. Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E.Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometryplatform for the identification and relative quantification of thesmall-molecule complement of biological systems. Anal Chem.200981:6656-6667.
18. Lustgarten MS, Price LL, Logvinenko T, et al. Identification of serumanalytes and metabolites associated with aerobic capacity. Eur J ApplPhysiol. 2013113:1311-1320.
19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF,Turner RC. Homeostasis model assessment: insulin resistance andbeta-cell function from fasting plasma glucose and insulin concentrationsin man. Diabetologia. 198528:412-419.
20. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practicaland powerful approach to multiple testing. J R Stat Soc Ser B.199557:289-300.
21. Storey JD, Tibshirani R. Statistical significance for genomewide studies.Proc Natl Acad Sci USA. 2003100:9440-9445.
22. Meyers KJ, Chu J, Mosley TH, Kardia SL. SNP-SNP interactionsdominate the genetic architecture of candidate genes associated withleft ventricular mass in African-Americans of the GENOA study.BMC Med Genet. 201011:160.
23. Jourdan C, Petersen AK, Gieger C, et al. Body fat free mass is associatedwith the serum metabolite profile in a population-based study.PLoS One. 20127:e40009.
24. Tom A, Nair KS. Assessment of branched-chain amino Acid statusand potential for biomarkers. J Nutr. 2006136(suppl 1):324S-330S.
25. Crozier SJ, Kimball SR, Emmert SW, Anthony JC, Jefferson LS. Oralleucine administration stimulates protein synthesis in rat skeletal muscle.J Nutr. 2005135:376-382.
26. Tischler ME, Desautels M, Goldberg AL. Does leucine,leucyl-tRNA, or some metabolite of leucine regulate proteinsynthesis and degradation in skeletal and cardiac muscle? J BiolChem. 1982257:1613-1621.
27. Mero AA, Ojala T, Hulmi JJ, Puurtinen R, Karila TA, SeppT.Effects of alpha-hydroxy-isocaproic acid on body composition,DOMS and performance in athletes. J Int Soc Sports Nutr. 20107:1.
28. McCormack SE, Shaham O, McCarthy MA, et al. Circulatingbranched-chain amino acid concentrations are associated with obesityand future insulin resistance in children and adolescents. PediatrObes. 20138:52-61.
29. W?tz P, Soininen P, Kangas AJ, et al. Branched-chain and aromaticamino acids are predictors of insulin resistance in young adults.Diabetes Care 201336:648-655.
30. Stern SE, Williams K, Ferrannini E, DeFronzo RA, Bogardus C, SternMP. Identification of individuals with insulin resistance using routineclinical measurements. Diabetes. 200554:333-339.
31. Mamer OA, Reimer ML. On the mechanisms of the formation ofL-alloisoleucine and the 2-hydroxy-3-methylvaleric acid stereoisomersfrom L-isoleucine in maple syrup urine disease patients and innormal humans. J Biol Chem. 1992267:22141-22147.
32. Fontella FU, Gassen E, Pulrolnik V, et al. Stimulation of lipid peroxidationin vitro in rat brain by the metabolites accumulating in maplesyrup urine disease. Metab Brain Dis. 200217:47-54.
33. Shin MJ, Park E, Lee JH, Chung N. Relationship between insulinresistance and lipid peroxidation and antioxidant vitamins in hypercholesterolemicpatients. Ann Nutr Metab. 200650:115-120.
34. Huffman KM, Shah SH, Stevens RD, et al. Relationships between circulatingmetabolic intermediates and insulin action in overweight toobese, inactive men and women. Diabetes Care 200932:1678-1683.
35. Smith EA, Macfarlane GT. Formation of phenolic and indolic compoundsby anaerobic bacteria in the human large intestine. MicrobEcol. 199733:180-188.
36. Wikoff WR, Anfora AT, Liu J, et al. Metabolomics analysis revealslarge effects of gut microflora on mammalian blood metabolites. ProcNatl Acad Sci USA. 2009106:3698-3703.
37. Byrne GI, Lehmann LK, Kirschbaum JG, Borden EC, Lee CM, BrownRR. Induction of tryptophan degradation in vitro and in vivo: a gammainterferon- stimulated activity. J Interferon Res. 19866:389-396.
38. K arbownik M, Reiter RJ, Garcia JJ, et al. Indole-3-propionic acid, amelatonin-related molecule, protects hepatic microsomal membranesfrom iron-induced oxidative damage: relevance to cancer reduction. JCell Biochem. 200181:507-513.
39. Sherratt HS, Veitch RK. Animal models for dicarboxylic aciduria. JInherit Metab Dis. 19847(suppl 1):52-56.
40. Tonsgard JH, Getz GS. Effect of Reye's syndrome serum on isolatedchinchilla liver mitochondria. J Clin Invest. 198576:816-825.