Recombinant bovine respiratory syncytial virus with deletion of the SH gene induces increased apoptosis and pro-inflammatory cytokines in vitro, and is attenuated and induces protective immunity in calves

Journal of General Virology

Volumn 95, Issue PART 6, 2014, Pages 1244-1254

  Taylor, Geraldine ^a   Wyld, Sara ^a   Valarcher, Jean Francois ^a,c   Guzman, Efrain ^a   Thom, Michelle ^a   Widdison, Stephanie ^a,d   Buchholz, Ursula J ^b  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL VETERINARY INSTITUTE   (Sweden)

^d General Bioinformatics Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 1BETA; RECOMBINANT BOVINE RESPIRATORY SYNCYTIAL VIRUS DELTA SH PROTEIN VACCINE; RESPIRATORY SYNCYTIAL VIRUS VACCINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALF (BOVINE); CONTROLLED STUDY; EPITHELIUM CELL; GENE DELETION; IMMUNE RESPONSE; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INOCULATION; MONOCYTE; MUCOSAL IMMUNITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; UPPER RESPIRATORY TRACT INFECTION; VIRUS GENE; VIRUS REPLICATION; WILD TYPE;

ANIMALS; APOPTOSIS; CATTLE; CATTLE DISEASES; CYTOKINES; GENE DELETION; GENES, VIRAL; HUMANS; IMMUNITY, MUCOSAL; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS VACCINES; RESPIRATORY SYNCYTIAL VIRUS, BOVINE; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; RESPIRATORY SYSTEM; RETROVIRIDAE PROTEINS, ONCOGENIC; TUMOR NECROSIS FACTOR-ALPHA; VACCINES, ATTENUATED; VACCINES, SYNTHETIC; VIRULENCE;

EID: 84900865263     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.064931-0     Document Type: Article

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