Preoperative enoxaparin versus postoperative semuloparin thromboprophylaxis in major abdominal surgery: A randomized controlled trial

Annals of Surgery

Volumn 259, Issue 6, 2014, Pages 1073-1079

  Kakkar, Ajay K ^a   Agnelli, Giancarlo ^b   Fisher, William ^c   George, Daniel ^d   Lassen, Michael R ^e   Mismetti, Patrick ^f   Mouret, Patrick ^g   Murphy, Judith ^g   Lawson, Francesca ^g   Turpie, Alexander G G ^h  

^a THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF PERUGIA   (Italy)

^c MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e Mental Health Services CPH   (Denmark)

^f UNIVERSITÉ JEAN MONNET   (France)

^g SANOFI   (France)

^h MCMASTER UNIVERSITY   (Canada)

Author keywords

Abdominal surgery; Semuloparin; Thromboprophylaxis

Indexed keywords

ENOXAPARIN; PLACEBO; SEMULOPARIN;

ABDOMINAL SURGERY; ADULT; ARTICLE; BLEEDING; CAUSE OF DEATH; COMPARATIVE STUDY; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; LAPAROTOMY; LEG PHLEBOGRAPHY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; OPERATION DURATION; OPERATIVE BLOOD LOSS; OUTCOME ASSESSMENT; PELVIS SURGERY; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUDDEN CARDIAC DEATH; THROMBOCYTOPENIA; THROMBOSIS PREVENTION;

ABDOMEN; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENOXAPARIN; FEMALE; FIBRINOLYTIC AGENTS; FOLLOW-UP STUDIES; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; RETROSPECTIVE STUDIES; SURGICAL PROCEDURES, OPERATIVE; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM; YOUNG ADULT;

EID: 84900861751     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0000000000000430     Document Type: Article

References (20)

1. Kakkar AK, Cohen AT, Tapson VF, et al. Venous thromboembolism risk and prophylaxis in the acute care hospital setting (ENDORSE survey): Findings in surgical patients. Ann Surg. 2010;251:330-338
2. Bergqvist D, Agnelli G, Cohen AT, et al. Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer. N Engl J Med. 2002;346:975-980
3. Prevention of fatal postoperative pulmonary embolism by lowdoses of heparin. An international multicentre trial. Lancet. 1975;2:45-51
4. Falck-Ytter Y, Francis CW, Johanson NA, et al. Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e278S-e325S.
5. Gould MK, Garcia DA, Wren SM, et al. Prevention of VTE in nonorthopedic surgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e227S-e277S
6. Lyman GH, Khorana AA, Falanga A, et al. American Society of Clinical Oncology guideline: Recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer. J Clin Oncol. 2007;25: 5490-5505
7. Viskov C, Just M, Laux V, et al. Description of the chemical and pharmacological characteristics of a new hemisynthetic ultra-low-molecular- weight heparin, AVE5026. J Thromb Haemost. 2009;7:1143-1151
8. Lassen MR, Dahl OE, Mismetti P, et al. AVE5026, a new hemisynthetic ultralow-molecular-weight heparin for the prevention of venous thromboembolism in patients after total knee replacement surgery-TREK: A dose-ranging study. J Thromb Haemost. 2009;7:566-572
9. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31-41
10. Rabinov K, Paulin S. Roentgen diagnosis of venous thrombosis in the leg. Arch Surg. 1972;104:134-144
11. Schulman S, Angerås U, Bergqvist D, et al. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients. J Thromb Haemost. 2010;8:202-204
12. Lassen MR, Fisher W, Mouret P, et al. Semuloparin for prevention of venous thromboembolism after major orthopedic surgery: Results from three randomized clinical trials, SAVE-HIP1, SAVE-HIP2 and SAVE-KNEE. J Thromb Haemost. 2012;10:822-832
13. Ockelford PA, Patterson J, Johns AS. A double-blind randomized placebo controlled trial of thromboprophylaxis in major elective general surgery using once daily injections of a low molecular weight heparin fragment (Fragmin). Thromb Haemost. 1989;62:1046-1049
14. Marassi A, Balzano G, Mari G, et al. Prevention of postoperative deep vein thrombosis in cancer patients. A randomized trial with low molecular weight heparin (CY 216). Int Surg. 1993;78:166-170
15. Bergqvist D, Flordal PA, Friberg B, et al. Thromboprophylaxis with a low molecular weight heparin (tinzaparin) in emergency abdominal surgery. A double-blind multicenter trial. Vasa. 1996;25:156-160
16. US Department of Health andHuman Services, Food andDrugAdministration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER). Guidance for industry. Drug-induced liver injury: Premarketing clinical evaluation. http://www.fda.gov/downloads/Drugs/ GuidanceComplianceRegulatoryInformation/Guidances/UCM174090.pdf. Accessed January 11, 2013
17. Agnelli G, Bergqvist D, Cohen AT, et al. Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery. Br J Surg. 2005;92:1212-1220
18. Agnelli G, George DJ, Kakkar AK, et al. Semuloparin for thromboprophylaxis in patients receiving chemotherapy for cancer. N Engl J Med. 2012;366:601-609
19. Bergqvist D, Agnelli G, Cohen AT, et al. Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer. N Engl J Med. 2002;346:975-980
20. Kakkar VV, Balibrea JL, Martínez-González J, et al. Extended prophylaxis with bemiparin for the prevention of venous thromboembolism after abdominal or pelvic surgery for cancer: The CANBESURE randomized study. J Thromb Haemost. 2010;8:1223-1229.