Improvement of the cytological diagnostic accuracy of follicular thyroid lesions by the use of the Ki-67 proliferative index in addition to cytokeratin-19 and HBME-1 immunomarkers: A study of 61 cases of liquid-based FNA cytology with histological controls

Cytopathology

Volumn 25, Issue 3, 2014, Pages 160-169

  Lacoste Collin, L ^a   d'Aure, D ^a   Berard E ^b   Rouquette, I ^a   Delisle, M B ^a   Courtade Saidi M ^a  

^a CHU RANGUEIL   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

Author keywords

Cytokeratin 19; Fine needle aspiration, FNA cytology; Follicular neoplasms; HBME 1; Ki 67; Risk of malignancy; Thyroid

Indexed keywords

CYTOKERATIN 19; HBME 1 PROTEIN; KI 67 ANTIGEN; TUMOR PROTEIN; UNCLASSIFIED DRUG; HBME-1 ANTIGEN; TUMOR MARKER;

ARTICLE; CANCER CYTODIAGNOSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; FINE NEEDLE ASPIRATION BIOPSY; FOLLICULAR CARCINOMA; FOLLICULAR THYROID LESION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LYMPHOCYTIC THYROIDITIS; MAJOR CLINICAL STUDY; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; THYROID CARCINOMA; THYROID TUMOR; ADENOCARCINOMA, FOLLICULAR; BIOSYNTHESIS; CARCINOMA; CELL PROLIFERATION; CYTODIAGNOSIS; DIAGNOSTIC USE; GENETICS; ISOLATION AND PURIFICATION; PATHOLOGY; THYROID NEOPLASMS; THYROID NODULE;

ADENOCARCINOMA, FOLLICULAR; BIOPSY, FINE-NEEDLE; CARCINOMA; CELL PROLIFERATION; CYTODIAGNOSIS; HUMANS; KERATIN-19; KI-67 ANTIGEN; THYROID NEOPLASMS; THYROID NODULE; TUMOR MARKERS, BIOLOGICAL;

EID: 84900846302     PISSN: 09565507     EISSN: 13652303     Source Type: Journal    
DOI: 10.1111/cyt.12128     Document Type: Article

References (24)

1. Cibas ES, Ali SZ. The Bethesda system for reporting thyroid cytopathology. Am J Clin Pathol 2009;132:658-65.
2. Ali SZ. Thyroid cytopathology: Bethesda and beyond. Acta Cytol 2011;55:4-12.
3. Ustün H, Astarci HM, Altunkaya C et al. Fine needle aspiration of follicular patterned lesions of the thyroid: diagnosis, management and follow-up according to thyroid Bethesda system. Acta Cytol 2012;56:361.69
4. Hassell LA, Gillies EM, Dunn ST. Cytologic and molecular diagnosis of thyroid cancers: is it time for routine reflex testing? Cancer (Cancer Cytopathol) 2012;120:7-17.
5. Baloch ZW, LiVolsi V. Fine-needle aspiration of the thyroid: today and tomorrow. Best Pract Res Clin Endocrinol Metab 2008;22:929-39.
6. Rodrigues HG, de Pontes AA, Adan LF. Use of molecular markers in samples obtained from preoperative aspiration of thyroid. Endocr J 2012;59:417-24.
7. Fillie AC, Asa SL, Geisinger KR et al. Utilization of ancillary studies in thyroid fine needle aspirates: a synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference. Diagn Cytopathol 2008;36:438-41.
8. Rossi ED, Morassi F, Santeusanio G, Zannoni GF, Fadda G. Thyroid fine needle aspiration cytology processed by ThinPrep: an additional slide decreased the number of inadequate results. Cytopathology 2010;21:97-102.
9. Rossi ED, Zannoni GF, Moncelsi S et al. Application of liquid-based cytology to fine-needle aspiration biopsies of the thyroid gland. Front Endocrinol 2012;3:57-60.
10. Skoog L, Tani E. Immunocytochemistry: an indispensable technique in routine cytology. Cytopathology 2011;22:215-29.
11. Cochand-Priollet B, Dahan H, Laloi-Michelin M et al. Immunocytochemistry with cytokeratin 19 and anti-human mesothelial cell antibody (HBME1) increases the diagnostic accuracy of thyroid fine-needle aspirations: preliminary report of 150 liquid-based fine-needle aspirations with histological control. Thyroid 2011;21:1067-73.
12. Fadda G, Rossi ED, Raffaelli M et al. Follicular thyroid neoplasms can be classified as low and high risk according to HBME-1 and Galectin-3 expression on liquid-based fine-needle cytology. Eur J Endocr 2011;165:447-53.
13. Sofiadis A, Tani E, Foukakis T et al. Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy. Int J Oncol 2009;35:369-74.
14. Pisani T, Pantellini F, Centanni M, Vecchione A, Giovagnoli MR. Immunocytochemical expression of Ki67 and laminin in Hurthle cell adenomas and carcinomas. Anticancer Res 2003;23:3323-6.
15. Erickson LA, Jin L, Wollan PC et al. Expression of p27kip1 and Ki-67 in benign and malignant thyroid tumors. Mod Pathol 1998;11:169-74.
16. Müssig K, Wehrmann T, Dittmann H et al. Expression of the proliferation marker Ki-67 associates with tumour staging and clinical outcome in differentiated thyroid carcinomas. Clin Endocrinol 2012;77:139-45.
17. Rossi ED, Raffaelli M, Minimo C et al. Immunocytochemical evaluation of thyroid neoplasms on thin-layer smears from fine-needle aspiration biopsies. Cancer Cytopathol 2005;105:87-95.
18. Vielh P, Mansuet-Lupo A, Polivka M, Saada M, Cochand-Priollet B. Update on thyroid immunocytochemistry and its value for managing patients with thyroid nodules. Ann Pathol 2006;26:340-5.
19. Pazaitou-Panayiotou K, Mygdakos N, Boglou K et al. Immunocytochemistry is a valuable tool in the diagnosis of papillary thyroid cancer in FNA's using liquid-based cytology. J Oncol 2010;2010:963926.
20. Chatzipantelis P, Kostantinou P, Kaklamanos M, Apostolou G, Salla C. The role of cytomorphology and proliferative activity in predicting biologic behavior of pancreatic neuroendocrine tumors: a study by endoscopic ultrasound-guided fine-needle aspiration cytology. Cancer Cytopathology 2009;117:211-6.
21. Guerriero E, Ferraro A, Desiderio D et al. UbcH10 expression on thyroid fine-needle aspirates. Cancer Cytopathol 2010;25:157-65.
22. Mehrotra A, Goel MM, Singh K. Ki-67 and AgNOR proliferative markers as diagnostic adjuncts to fine needle aspiration cytology of thyroid follicular lesions. Anal Quant Cytol Histol 2002;24:205-11.
23. Kjellman P, Wallin G, Höög A et al. MIB-1 index in thyroid tumors: a predictor of the clinical course in papillary thyroid carcinoma. Thyroid 2003;13:371-80.
24. Erickson LA, Jin L, Goellner JR et al. Pathologic features, proliferative activity, and cyclin D1 expression in Hurthle cell neoplasms of the thyroid. Mod Pathol 2000;13:186-92.