Therapeutic effects of stem cell on hyperglycemia, hyperlipidemia, and oxidative stress in alloxan-treated rats

Molecular and Cellular Biochemistry

Volumn 391, Issue 1-2, 2014, Pages 193-200

  El Tantawy, Walid Hamdy ^a   Haleem, Ekram Nemr Abd Al ^b  

^a NATIONAL ORGANIZATION FOR DRUG CONTROL AND RESEARCH NODCAR   (Egypt)

^b Al Azhar University   (Egypt)

Author keywords

Alloxan; Diabetes mellitus; Hyperlipidemia; Mesenchymal stem cell; Oxidative stress

Indexed keywords

ALLOXAN; CHOLESTEROL; GLUCOSE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLYCOGEN; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; SIALIC ACID; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; ALPHA TOCOPHEROL; GLUCOSE BLOOD LEVEL; LIPID; N ACETYLNEURAMINIC ACID; NITRIC OXIDE;

ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; HISTOPATHOLOGY; HYPERGLYCEMIA; HYPERLIPIDEMIA; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; LIPOPROTEIN BLOOD LEVEL; MALE; MESENCHYMAL STEM CELL; NONHUMAN; OXIDATIVE STRESS; RAT; THERAPY EFFECT; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; COMPLICATION; CYTOLOGY; DIABETES MELLITUS, EXPERIMENTAL; FLOW CYTOMETRY; HYPERLIPIDEMIAS; LIVER; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; PANCREAS; PATHOLOGY; WISTAR RAT;

RATTUS;

ALLOXAN; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; FLOW CYTOMETRY; GLUTATHIONE; GLYCOGEN; HYPERGLYCEMIA; HYPERLIPIDEMIAS; INSULIN; LIPIDS; LIVER; MALE; MALONDIALDEHYDE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; N-ACETYLNEURAMINIC ACID; NITRIC OXIDE; OXIDATIVE STRESS; PANCREAS; RATS, WISTAR; VITAMIN E;

EID: 84900828978     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2002-x     Document Type: Article

References (40)

1. Rajalakshmi M, Eliza J, Priya CE, Nirmala A, Daisy P (2009) Anti-diabetic properties of Tinospora cordifolia stem extracts on streptozotocin-induced diabetic rats. Afr J Pharm Pharmacol 3:171-180
2. Meier JJ, Bhushan A, Butlet PC (2006) The potential for stem cell therapy in diabetes. Pediatr Res 59:65R-73R
3. Halliwell B (2007) Oxidative stress and cancer: have we moved forward? Biochem J 401:1-11
4. Taniyama Y, Griendling KK (2003) Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension 42:1075-1081
5. Wilcox CS, Gutterman D (2005) Focus on oxidative stress in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol 288:H3-H6
6. Abdel Aziz MT, Atta HM, Mahfouz S, Fouad HH, Roshdy NK, Ahmed HH, Rashed LA, Sabry D, Hassouna AA, Hasan NM (2007) Therapeutic potential of bone marrow derived mesenchymal stem cells on experimental liver fibrosis. Clin Biochem 40:893-899
7. Si YL, Zhao YL, Hao HJ, Fu XB, Han WD (2011) MSCs: biological characteristics, clinical applications and their outstanding concerns. Ageing Res Rev 10:93-103
8. Ankrum J, Karp JM (2010) Mesenchymal stem cell therapy: two steps forward, one step back. Trends Mol Med 16:203-209
9. Song H, Song BW, Cha MJ, Choi IG, Hwang KC (2010) Modification of mesenchymal stem cells for cardiac regeneration. Expert Opin Biol Ther 10:309-319
10. Mizuno H (2010) Adipose-derived stem and stromal cells for cell-based therapy: current status of preclinical studies and clinical trials. Curr Opin Mol Ther 12:442-449
11. Alhadlaq A, Mao JJ (2004) Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev 13:436-448
12. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502
13. Baker H, Frank O, De Angelis B, Feingold S (1951) Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol. Nutr Rep Int 21:531-536
14. Sydow GA (1985) Simplified quick method for determination of sialic acid in serum. Biomed Biochim Acta 44:1721-1723
15. Van Der Vies J (1954) Two methods for the determination of glycogen in liver. Biochem J 57:410-416
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265
17. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 74:214-226
18. Marklund SL, Marklund G (1974) Involvement of the superoxide anion radical in the autooxidation of pyrogallol and convenient assay for superoxide dismutase. Eur J Biochem 47:469-474
19. Habig WH, Pabst MJ, Jakoby W (1974) Glutathione S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139
20. Ohkawa H, Ohishi N, Yagi K (1979) Assay of lipid peroxide in animal tissue by thiobarbituric acid reaction. Ann Biochem 95:351-358
21. Jiang R, Han Z, Zhuo G, Qu X, Li X, Wang X, Shao Y, Yang S, Han ZC (2011) Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study. Front Med 5:94-100
22. Mohini P, Subhash P, Manohar P, Abhijit T, Vijay N (2012) Effect of thespesone-vanadium complex in alloxan induced diabetic rats. Afr J Pharm Pharmacol 6:692-697
23. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343: 230-238
24. Soria B, Roche E, Berna G (2000) Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49:157-162
25. Abdel Aziz MT, El-Asmar MF, Haidara M, Atta HM, Roshdy NK, Rashed LA, Sabry D, Youssef MA, Abdel Aziz AT, Moustafa M (2008) Effect of bone marrow-derived mesenchymal stem cells on cardiovascular complications in diabetic rats. Med Sci Monit 14:BR249-BR255
26. Ezquer F, Ezquer M, Contador D, Ricca M, Simon V, Conget P (2012) The antidiabetic effect of mesenchymal stem cells is unrelated to their trans-differentiation potential but to their capability to restore Th1/Th2 balance and to modify the pancreatic microenvironment. Stem Cells 30:1664-1674
27. Hao H, Liu J, Shen J, Zhao Y, Liu H, Hou Q, Tong C, Ti D, Dong L, Cheng Y, Mub Y, Liu J, Fu X, Han W (2013) Multiple intravenous infusions of bone marrow mesenchymal stem cells reverse hyperglycemia in experimental type 2 diabetes rats. Biochem Biophys Res Commun 436:418-423
28. Li YY, Liu HH, Chen HL, Li YP (2012) Adipose-derived mesenchymal stem cells ameliorate STZ-induced pancreas damage in type 1 diabetes. Biomed Mater Eng 22:97-103
29. Tsai PJ, Wang HS, Lin CH, Weng ZC, Chen TH, Shyu JF (2014) Intraportal injection of insulin-producing cells generated from human bone marrow mesenchymal stem cells decreases blood glucose level in diabetic rats. Endocr Res 39:26-33
30. Si Y, Zhao Y, Hao H, Liu J, Guo Y, Mu Y, Shen J, Cheng Y, Fu X, Han W (2012) Infusion of mesenchymal stem cells ameliorate hyperglycemia in Type 2 diabetic rats: Identification of a novel role in improving insulin sensitivity. Diabetes 61:1616-1625
31. Abdi R, Fiorina P, Adra CN, Atkinson M, Sayegh MH (2008) Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes. Diabetes 57:1759-1767
32. Phinney DG, Prockop DJ (2007) Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 25:2896-2902
33. Mathé D (1995) Dyslipidemia and diabetes: animal models. Diabetes Metab 21:106-111
34. Ulicná O, Volkovová K, Istvánová B (1996) Bioenergetics of liver mitochondria in rats in experimental insulin-dependent diabetes. Bratisl Lek Listy 97:619-624
35. Wasan KM, Ng SP, Wong W, Rodrigues BB (1998) Streptozotocin-and alloxan-induced diabetes modifies total plasma and lipoprotein lipid concentration and composition without altering cholesteryl ester transfer activity. Pharmacol Toxicol 83:169-175
36. Al-Shamaony L, Al-Khazraji SM, Twaij HAA (1994) Hypoglycemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood glucose parameters in diabetic animals. J Ethnopharmacol 43:167-171
37. Ahmed D, Sharma M, Mukerjee A, Ramteke PW, Kumar V (2013) Improved glycemic control, pancreas protective and hepatoprotective effect by traditional poly-herbal formulation "Qurs Tabasheer" in streptozotocin induced diabetic rats. BMC Complement Altern Med 13:10-25
38. Andallu B, Vinay Kumar AV, Varadacharyulu NCh (2009) Lipid abnormalities in streptozotocin-diabetes: amelioration by Morus indica L. cv Suguna leaves. Int J Diabetes Dev Ctries 29:123-128
39. Yilmaz G, Yilmaz FM, Aral Y, Yucel D (2007) Levels of serum sialic acid and thiobarbituric acid reactive substances in subjects with impaired glucose tolerance and type 2 diabetes mellitus. J Clin Lab Anal 21:260-264
40. Pileggi A (2012) Mesenchymal stem cells for the treatment of diabetes. Diabetes 61:1355-1356