Fall in Hematocrit per 1000 parasites cleared from peripheral blood: A simple method for estimating drug-related fall in hematocrit after treatment of malaria infections

American Journal of Therapeutics

Volumn 21, Issue 3, 2014, Pages 193-197

  Gbotosho, Grace Olusola ^a,b   Okuboyejo, Titilope ^a   Happi, Christian Tientcha ^a,b   Sowunmi, Akintunde ^a,b  

^a UNIVERSITY OF IBADAN   (Nigeria)

^b UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

antimalarial drugs; children; fall in hematocrit; hematocrit conservation

Indexed keywords

AMODIAQUINE PLUS ARTESUNATE; ARTEMETHER PLUS BENFLUMETOL; AMODIAQUINE; AMODIAQUINE, ARTESUNATE DRUG COMBINATION; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; DRUG COMBINATION; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE;

ANEMIA; ARTICLE; BODY TEMPERATURE; CHILD; ERYTHROCYTE COUNT; FEMALE; FEVER; HEMATOCRIT; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; PARASITE CLEARANCE; PARASITE LOAD; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TREATMENT RESPONSE; COMPARATIVE STUDY; COMPLICATION; CONTROLLED STUDY; DRUG COMBINATION; ISOLATION AND PURIFICATION; MALARIA, FALCIPARUM; PARASITEMIA; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; TIME; TREATMENT OUTCOME;

AMODIAQUINE; ANEMIA; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; DRUG COMBINATIONS; ETHANOLAMINES; FEMALE; FLUORENES; HEMATOCRIT; HUMANS; MALARIA, FALCIPARUM; MALE; PARASITEMIA; PLASMODIUM FALCIPARUM; TIME FACTORS; TREATMENT OUTCOME;

EID: 84900819583     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/MJT.0b013e31822119d9     Document Type: Article

References (14)

1. Hedberg K, Shaffer N, Davachi F, et al. Plasmodium falciparum associated anemia in children at a large urban hospital in Zaire. Am J Trop Med Hyg. 1993;48:365-371.
2. Price R, Simpson JA, Nosten F, et al. Factors contributing to anemia after uncomplicated falciparum malaria. Am J Trop Med Hyg. 2001;65:614-622.
3. Crawley J. Reducing the burden of anemia in infants and young children in malaria-endemic countries of Africa. Am J Trop Med Hyg. 2004;71(suppl 2):25-34.
4. Ehrhardt S, Burchard GD, Mantel C, et al. Malaria, anemia, and malnutrition in African children-defining interventional priorities. J Infect Dis. 2006;94:108-114.
5. Davis TM, Krishna S, Looareesuwan S, et al. Erythrocyte sequestration and anemia in severe falciparum malaria: analysis of acute changes in venous hematocrit using a simplemathematicalmodel. J Clin Invest. 1990;86:793-800.
6. Jakeman CN, Saul A, Hogarth WL, et al. Anaemia of acute malaria infections in non-immune patients primarily results from the destruction of uninfected erythrocytes. Parasitol. 1999;119:127-133.
7. Newton PN, Chotivanich K, Chierakul W, et al. Acomparisonof the in vivo kinetics of Plasmodium falciparum ring-infected erythrocyte surface antigen-positive and -negative erythrocytes. Blood. 2001;15:450-457.
8. Price RN, Simpson JA, Nosten F, et al. factors contributing to anemia after uncomplicated falciparum malaria. Am J Trop Med Hyg. 2001;65:614-622.
9. Chotivanich K, Udomsangpetch R, Dondorp A, et al. The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria. J Infect Dis. 2000;182:629-633.
10. World Health Organization. Severe falciparum malaria. Trans R Soc Trop Med Hyg. 2000;94(suppl 1):1-90.
11. Gbotosho GO, Sowunmi A, Okuboyejo TM, et al. A simple dose regimen of artesunate and amodiaquine based on age or body weight range for uncomplicated falciparum malaria in children: comparison of therapeutic efficacy with standard dose regimen of artesunate and amodiaquine and artemether-lumefantrine [published online ahead of print April 23, 2011]. Am J Ther. doi: 10.1097/MJT.0b013e318209e17b.
12. Epi Info.Version 6. Atlanta: Centers for Disease Control and Prevention; 1994.
13. SPSS for Windows Release 10.01 (Standard Version). Chicago: SPSS Inc; 1999.
14. Premji Z, Umeh RE, Owusu-Agyei S, et al. Chlorproguanil-dapsone- Aretesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria. PLoS One. 2009;4:e6682.