Predicting cognitive ability in ageing cohorts using type 2 diabetes genetic risk

Diabetic Medicine

Volumn 31, Issue 6, 2014, Pages 714-720

  Luciano, M ^a   Mottus R ^a,b   Harris, S E ^a   Davies, G ^a   Payton, A ^c   Ollier, W E R ^c   Horan, M A ^d   Starr, J M ^a   Porteous, D J ^a   Pendleton, N ^d   Deary, I J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF TARTU   (Estonia)

^c CIGMR School of Cancer and Enabling Sciences   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C;

ADULT; AGED; AGING; ARTICLE; ASSOCIATION; COGNITION; COGNITIVE DEFECT; COMORBIDITY; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HUMAN; INTELLIGENCE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PLEIOTROPY; PREDICTION; RECALL; RECOGNITION; RESPONSE TIME; SELF REPORT; SINGLE NUCLEOTIDE POLYMORPHISM; COHORT ANALYSIS; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PSYCHOLOGY; RISK FACTOR;

ADULT; AGED; COGNITION DISORDERS; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84900809230     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/dme.12389     Document Type: Article

References (29)

1. Kodl CT, Seaquist ER. Cognitive dysfunction and diabetes mellitus. Endocr Rev 2008; 29: 494-511.
2. Strachan MW, Reynolds RM, Marioni RE, Price JF. Cognitive function, dementia and type 2 diabetes mellitus in the elderly. Nat Rev Endocrinol 2011; 7: 108-114.
3. Biessels GJ, Deary IJ, Ryan CM. Cognition and diabetes: a lifespan perspective. Lancet Neurol 2008; 7: 184-190.
4. Stranahan AM, Lee K, Becker KG, Zhang Y, Maudsley S, Martin B et al. Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice. Neurobiol Aging 2010; 31: 1937-1949.
5. Anthopoulos PG, Hamodrakas SJ, Bagos PG. Apolipoprotein E polymorphisms and type 2 diabetes: a meta-analysis of 30 studies including 5423 cases and 8197 controls. Mol Genet Metab 2010; 100: 283-291.
6. De Jager PL, Shulman JM, Chibnik LB, Keenan BT, Raj T, Wilson RS et al. A genome-wide scan for common variants affecting the rate of age-related cognitive decline. Neurobiol Aging 1017; 2012(33): e1-15.
7. Allen KV, Frier BM, Strachan MW. The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations. Eur J Pharmacol 2004; 490: 169-75.
8. Stewart R, Liolitsa D. Type 2 diabetes mellitus, cognitive impairment and dementia. Diabet Med 1999; 16: 93-112.
9. Bruce DG, Casey GP, Grange V, Clarnette RC, Almeida OP, Foster JK et al. Cognitive impairment, physical disability and depressive symptoms in older diabetic patients: the Fremantle Cognition in Diabetes Study. Diabetes Res Clin Pract 2003; 61: 59-67.
10. McNay EC, Recknagel AK. Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes. Neurobiol Learn Mem 2011; 96: 432-442.
11. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 445: 881-885.
12. Cauchi S, Proenca C, Choquet H, Gaget S, De Graeve F, Marre M et al. Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. J Mol Med 2008; 86: 341-348.
13. Huentelman MJ, Papassotiropoulos A, Craig DW, Hoerndli FJ, Pearson JV, Huynh KD et al. Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance. Hum Mol Genet 2007; 16: 1469-1477.
14. Demirkan A, Penninx BW, Hek K, Wray NR, Amin N, Aulchenko YS et al. Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Mol Psychiatry 2011; 16: 773-783.
15. Morris AP, Voight BF, Teslovich TM, Ferreira T, Segre AV, Steinthorsdottir V et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012; 44: 981-990.
16. Davies G, Tenesa A, Payton A, Yang J, Harris SE, Liewald D et al. Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry 2011; 16: 996-1005.
17. Deary IJ, Gow AJ, Pattie A, Starr JM. Cohort Profile: The Lothian Birth Cohorts of 1921 and 1936. Int J Epidemiol 2012; 41: 1576-1584.
18. Rabbitt P, Donlan C, Bent N, McInnes L, Abson V. The University of Manchester Age and Cognitive Performance Research Centre and North East Age Research Longitudinal Programmes, 1982 to 1997. Z Gerontol 1993; 26: 176-83.
19. Lopez LM, Harris SE, Luciano M, Liewald D, Davies G, Gow AJ et al. Evolutionary conserved longevity genes and human cognitive abilities in elderly cohorts. Eur J Hum Genet 2012; 20: 341-347.
20. Luciano M, Hansell NK, Lahti J, Davies G, Medland SE, Raikkonen K et al. Whole genome association scan for genetic polymorphisms influencing information processing speed. Biol Psychol 2011; 86: 193-202.
21. Davies G, Harris SE, Reynolds CA, Payton A, Knight HM, Liewald DC et al. A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. Mol Psychiatry 2014; 19: 76-87.
22. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575.
23. R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, 2011.
24. Bonilla C, Lawlor DA, Ben-Shlomo Y, Ness AR, Gunnell D, Ring SM, et al. Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children. BMC Med Genet 2012; 13: 90.
25. Olsson GM, Hulting AL, Montgomery SM. Cognitive function in children and subsequent type 2 diabetes. Diabetes Care 2008; 31: 514-516.
26. Corley J, Gow AJ, Starr JM, Deary IJ. Is Body Mass Index in Old Age Related to Cognitive Abilities? The Lothian Birth Cohort 1936 Study. Psychol Aging 2010; 25: 867-875.
27. Gottfredson LS. Intelligence: Is it the epidemiologists' elusive "Fundamental cause" of social class inequalities in health? J Pers Soc Psychol 2004; 86: 174-199.
28. Batty GD, Gale CR, Mortensen LH, Langenberg C, Shipley MJ, Deary IJ. Pre-morbid intelligence, the metabolic syndrome and mortality: the Vietnam Experience Study. Diabetologia 2008; 51: 436-443.
29. Evans DM, Visscher PM, Wray NR. Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk. Hum Mol Genet 2009; 18: 3525-3531.