Discovery of the biology of the ubiquitin system

JAMA

Volumn 311, Issue 19, 2014, Pages 1969-1970

  Varshavsky, Alexander ^a  

^a California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 34; MAT ALPHA2; PROTEASOME; REPRESSOR PROTEIN; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN CONJUGATING ENZYME RAD6; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL FREE SYSTEM; CLINICAL MEDICINE; CONJUGATION; DNA DAMAGE; DNA REPAIR; MOLECULAR BIOLOGY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; SHORT SURVEY; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION REGULATION; UBIQUITINATION;

BIOLOGY; HISTORY, 20TH CENTURY; HUMANS; PHYSIOLOGY; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 84900790633     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2014.5549     Document Type: Short Survey

References (10)

1. Hershko A, Ciechanover A, Varshavsky A. Basic Medical Research Award: the ubiquitin system. Nat Med. 2000;6(10):1073-1081.
2. Varshavsky A. The early history of the ubiquitin field. Protein Sci. 2006;15(3):647-654.
3. Varshavsky A. Discovery of cellular regulation by protein degradation. J Biol Chem. 2008;283(50):34469-34489.
4. Varshavsky A. In: Hargittai I, Hargittai M, eds. Candid Science. Vol 6. London, UK: Imperial College Press; 2006:311-359.
5. Hershko A, Ciechanover A, Heller H, Haas AL, Rose IA. Proposed role of ATP in protein breakdown. Proc Natl Acad Sci U S A. 1980;77(4):1783-1786.
6. Förster F, Unverdorben P, Sledź P, Baumeister W. Unveiling the long-held secrets of the 26S proteasome. Structure. 2013;21(9):1551-1562.
7. Bachmair A, Finley D, Varshavsky A. In vivo half-life of a protein is a function of its amino-terminal residue. Science. 1986;234(4773):179-186. (Pubitemid 17186094)
8. Varshavsky A. The N-end rule pathway and regulation by proteolysis. Protein Sci. 2011;20:1298-1345.
9. Shemorry A, Hwang C-S, Varshavsky A. Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Mol Cell. 2013;50(4):540-551.
10. Kim H-K, Kim RR, Oh JH, Cho H, Varshavsky A, Hwang CS. The N-terminal methionine of cellular proteins as a degradation signal. Cell. 2014;156(1-2):158-169.