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Volumn 62, Issue 5, 2014, Pages 857-864

New oral anticoagulants in elderly adults: Evidence from a meta-analysis of randomized trials

Author keywords

elderly; meta analysis; new anticoagulants

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; DABIGATRAN; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; RIVAROXABAN;

EID: 84900522812     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.12799     Document Type: Article
Times cited : (219)

References (37)
  • 1
    • 66249097380 scopus 로고    scopus 로고
    • Use of anticoagulants in elderly patients: Practical recommendations
    • Robert-Ebadi H, Le Gal G, Righini M,. Use of anticoagulants in elderly patients: Practical recommendations. Clin Interv Aging 2009; 4: 165-177.
    • (2009) Clin Interv Aging , vol.4 , pp. 165-177
    • Robert-Ebadi, H.1    Le Gal, G.2    Righini, M.3
  • 2
    • 33748702279 scopus 로고    scopus 로고
    • Management of venous thromboembolism in the elderly
    • Spyropoulos AC, Merli G,. Management of venous thromboembolism in the elderly. Drugs Aging 2006; 23: 651-671.
    • (2006) Drugs Aging , vol.23 , pp. 651-671
    • Spyropoulos, A.C.1    Merli, G.2
  • 3
    • 84875222876 scopus 로고    scopus 로고
    • New oral anticoagulants in elderly patients with atrial fibrillation
    • Deedwania PC,. New oral anticoagulants in elderly patients with atrial fibrillation. Am J Med 2013; 126: 289-296.
    • (2013) Am J Med , vol.126 , pp. 289-296
    • Deedwania, P.C.1
  • 4
    • 0025779484 scopus 로고
    • Atrial fibrillation as an independent risk factor for stroke: The Framingham Study
    • Wolf PA, Abbott RD, Kannel WB,. Atrial fibrillation as an independent risk factor for stroke: The Framingham Study. Stroke 1991; 22: 983-988.
    • (1991) Stroke , vol.22 , pp. 983-988
    • Wolf, P.A.1    Abbott, R.D.2    Kannel, W.B.3
  • 5
    • 77952030881 scopus 로고    scopus 로고
    • Improving stroke risk stratification in atrial fibrillation
    • Lip GY, Halperin JL,. Improving stroke risk stratification in atrial fibrillation. Am J Med 2010; 123: 484-488.
    • (2010) Am J Med , vol.123 , pp. 484-488
    • Lip, G.Y.1    Halperin, J.L.2
  • 6
    • 0035854054 scopus 로고    scopus 로고
    • Validation of clinical classification schemes for predicting stroke: Results from the National Registry of Atrial Fibrillation
    • Gage BF, Waterman AD, Shannon W, et al. Validation of clinical classification schemes for predicting stroke: Results from the National Registry of Atrial Fibrillation. JAMA 2001; 285: 2864-2870.
    • (2001) JAMA , vol.285 , pp. 2864-2870
    • Gage, B.F.1    Waterman, A.D.2    Shannon, W.3
  • 7
    • 76749163232 scopus 로고    scopus 로고
    • Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: The Euro Heart Survey on Atrial Fibrillation
    • Lip GY, Nieuwlaat R, Pisters R, et al. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: The Euro Heart Survey on Atrial Fibrillation. Chest 2010; 137: 263-272.
    • (2010) Chest , vol.137 , pp. 263-272
    • Lip, G.Y.1    Nieuwlaat, R.2    Pisters, R.3
  • 8
    • 61849170118 scopus 로고    scopus 로고
    • Full accounting of diabetes and pre-diabetes in the U.S. Population in 1988-1994 and 2005-2006
    • Cowie CC, Rust KF, Ford ES, et al. Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care 2009; 32: 287-294.
    • (2009) Diabetes Care , vol.32 , pp. 287-294
    • Cowie, C.C.1    Rust, K.F.2    Ford, E.S.3
  • 9
    • 78649344437 scopus 로고    scopus 로고
    • Venous thrombosis in the elderly: Incidence, risk factors and risk groups
    • Engbers MJ, van Hylckama Vlieg A, Rosendaal FR,. Venous thrombosis in the elderly: Incidence, risk factors and risk groups. J Thromb Haemost 2010; 8: 2105-2112.
    • (2010) J Thromb Haemost , vol.8 , pp. 2105-2112
    • Engbers, M.J.1    Van Hylckama Vlieg, A.2    Rosendaal, F.R.3
  • 10
    • 84872273073 scopus 로고    scopus 로고
    • Oral anticoagulation in elderly adults with atrial fibrillation: Integrating new options with old concepts
    • Zarraga IG, Kron J,. Oral anticoagulation in elderly adults with atrial fibrillation: Integrating new options with old concepts. J Am Geriatr Soc 2013; 61: 143-150.
    • (2013) J Am Geriatr Soc , vol.61 , pp. 143-150
    • Zarraga, I.G.1    Kron, J.2
  • 11
    • 84856784474 scopus 로고    scopus 로고
    • Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    • Ageno W, Gallus AS, Wittkowsky A, et al. Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141: e44S-e88S.
    • (2012) Chest , vol.141
    • Ageno, W.1    Gallus, A.S.2    Wittkowsky, A.3
  • 12
    • 84869838484 scopus 로고    scopus 로고
    • Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: Direct and adjusted indirect meta-analysis of randomised controlled trials
    • Fox BD, Kahn SR, Langleben D, et al. Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: Direct and adjusted indirect meta-analysis of randomised controlled trials. BMJ 2012; 345: e7498.
    • (2012) BMJ , vol.345
    • Fox, B.D.1    Kahn, S.R.2    Langleben, D.3
  • 13
    • 84869236631 scopus 로고    scopus 로고
    • Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: A systematic review and meta-analysis of the literature
    • Dentali F, Riva N, Crowther M, et al. Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: A systematic review and meta-analysis of the literature. Circulation 2012; 126: 2381-2391.
    • (2012) Circulation , vol.126 , pp. 2381-2391
    • Dentali, F.1    Riva, N.2    Crowther, M.3
  • 14
    • 79960965512 scopus 로고    scopus 로고
    • New anticoagulant drugs among elderly patients is caution necessary? Comment on "the use of dabigatran in elderly patients"
    • Jacobs JM, Stessman J,. New anticoagulant drugs among elderly patients is caution necessary? Comment on "The use of dabigatran in elderly patients". Arch Intern Med 2011; 171: 1287-1288.
    • (2011) Arch Intern Med , vol.171 , pp. 1287-1288
    • Jacobs, J.M.1    Stessman, J.2
  • 15
    • 79960955075 scopus 로고    scopus 로고
    • The use of dabigatran in elderly patients
    • Legrand M, Mateo J, Aribaud A, et al. The use of dabigatran in elderly patients. Arch Intern Med 2011; 171: 1285-1286.
    • (2011) Arch Intern Med , vol.171 , pp. 1285-1286
    • Legrand, M.1    Mateo, J.2    Aribaud, A.3
  • 16
    • 84857853180 scopus 로고    scopus 로고
    • Bleeding risk with dabigatran in the frail elderly
    • Harper P, Young L, Merriman E,. Bleeding risk with dabigatran in the frail elderly. N Engl J Med 2012; 366: 864-866.
    • (2012) N Engl J Med , vol.366 , pp. 864-866
    • Harper, P.1    Young, L.2    Merriman, E.3
  • 17
    • 84859703006 scopus 로고    scopus 로고
    • Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment
    • Wychowski MK, Kouides PA,. Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment. Ann Pharmacother 2012; 46: e10.
    • (2012) Ann Pharmacother , vol.46
    • Wychowski, M.K.1    Kouides, P.A.2
  • 18
    • 69149107727 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration
    • Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. Ann Intern Med 2009; 151: W65-W94.
    • (2009) Ann Intern Med , vol.151
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3
  • 19
    • 70049099036 scopus 로고    scopus 로고
    • Assessing risk of bias in included studies
    • Version 5.1.0 Higgins J.P.T. Green S. eds. (updated March 2011). Accessed April 5, 2013
    • Higgins JPT, Altman DG, Sterne JAC,. Assessing risk of bias in included studies. In:, Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 (updated March 2011). Available at http://www.cochrane-handbook.org Accessed April 5, 2013.
    • Cochrane Handbook for Systematic Reviews of Interventions
    • Higgins, J.P.T.1    Altman, D.G.2    Sterne, J.A.C.3
  • 20
    • 23044505564 scopus 로고    scopus 로고
    • Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in nonsurgical patients
    • Schulman S, Kearon C,. Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in nonsurgical patients. J Thromb Haemost 2005; 3: 692-694.
    • (2005) J Thromb Haemost , vol.3 , pp. 692-694
    • Schulman, S.1    Kearon, C.2
  • 21
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins JP, Thompson SG,. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 1539-1558.
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 22
    • 78650619315 scopus 로고    scopus 로고
    • Oral rivaroxaban for symptomatic venous thromboembolism
    • EINSTEIN Investigators
    • EINSTEIN Investigators, Bauersachs R, Berkowitz SD, Brenner B, et al. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010; 363: 2499-2510.
    • (2010) N Engl J Med , vol.363 , pp. 2499-2510
    • Bauersachs, R.1    Berkowitz, S.D.2    Brenner, B.3
  • 23
    • 84859385808 scopus 로고    scopus 로고
    • Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
    • EINSTEIN-PE Investigators
    • EINSTEIN-PE Investigators, Büller HR, Prins MH, Lensin AW, et al. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 2012; 366: 1287-1297.
    • (2012) N Engl J Med , vol.366 , pp. 1287-1297
    • Büller, H.R.1    Prins, M.H.2    Lensin, A.W.3
  • 24
    • 84873514413 scopus 로고    scopus 로고
    • Rivaroxaban for thromboprophylaxis in acutely ill medical patients
    • MAGELLAN Investigators
    • Cohen AT, Spiro TE, Büller HR, et al.; MAGELLAN Investigators. Rivaroxaban for thromboprophylaxis in acutely ill medical patients. N Engl J Med 2013; 368: 513-523.
    • (2013) N Engl J Med , vol.368 , pp. 513-523
    • Cohen, A.T.1    Spiro, T.E.2    Büller, H.R.3
  • 25
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • ROCKET AF Investigators
    • Patel MR, Mahaffey KW, Garg J, et al.; ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011; 365: 883-891.
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 26
    • 84873596181 scopus 로고    scopus 로고
    • Apixaban for extended treatment of venous thromboembolism
    • AMPLIFY-EXT Investigators
    • Agnelli G, Buller HR, Cohen A, et al.; AMPLIFY-EXT Investigators. Apixaban for extended treatment of venous thromboembolism. N Engl J Med 2013; 368: 699-708.
    • (2013) N Engl J Med , vol.368 , pp. 699-708
    • Agnelli, G.1    Buller, H.R.2    Cohen, A.3
  • 27
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • ARISTOTLE Committees and Investigators
    • Granger CB, Alexander JH, McMurray JJ, et al.; ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011; 365: 981-992.
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.3
  • 28
    • 79952301326 scopus 로고    scopus 로고
    • Apixaban in patients with atrial fibrillation
    • AVERROES Steering Committee and Investigators
    • Connolly SJ, Eikelboom J, Joyner C, et al.; AVERROES Steering Committee and Investigators. Apixaban in patients with atrial fibrillation. N Engl J Med 2011; 364: 806-817.
    • (2011) N Engl J Med , vol.364 , pp. 806-817
    • Connolly, S.J.1    Eikelboom, J.2    Joyner, C.3
  • 29
    • 84874003257 scopus 로고    scopus 로고
    • Extended use of dabigatran, warfarin, or placebo in venous thromboembolism
    • Schulman S, Kearon C, Kakkar AK, et al. Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. N Engl J Med 2013; 368: 709-718.
    • (2013) N Engl J Med , vol.368 , pp. 709-718
    • Schulman, S.1    Kearon, C.2    Kakkar, A.K.3
  • 30
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • RE-LY Steering Committee and Investigators
    • Connolly SJ, Ezekowitz MD, Yusuf S, et al.; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361: 1139-1151.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 31
    • 84862907587 scopus 로고    scopus 로고
    • Rivaroxaban in patients with a recent acute coronary syndrome
    • ATLAS ACS 2-TIMI 51 Investigators
    • Mega JL, Braunwald E, Wiviott SD, et al.; ATLAS ACS 2-TIMI 51 Investigators. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med 2012; 366: 9-19.
    • (2012) N Engl J Med , vol.366 , pp. 9-19
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3
  • 32
    • 84879096748 scopus 로고    scopus 로고
    • Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the ROCKET-AF Trial
    • Halperin J, Wojdyla D, Piccini JP, et al. Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the ROCKET-AF Trial. Stroke 2012; 43: A148.
    • (2012) Stroke , vol.43
    • Halperin, J.1    Wojdyla, D.2    Piccini, J.P.3
  • 33
    • 84900538270 scopus 로고    scopus 로고
    • Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation
    • Halvorsen S, Wallentin L, Yang H, et al. Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation. J Am Coll Cardiol 2013; 61 (Suppl 10): E315.
    • (2013) J Am Coll Cardiol , vol.61 , Issue.SUPPL. 10
    • Halvorsen, S.1    Wallentin, L.2    Yang, H.3
  • 34
    • 84865189210 scopus 로고    scopus 로고
    • New anticoagulant treatments to protect against stroke in atrial fibrillation
    • Potpara TS, Lip GY, Apostolakis S,. New anticoagulant treatments to protect against stroke in atrial fibrillation. Heart 2012; 98: 1341-1347.
    • (2012) Heart , vol.98 , pp. 1341-1347
    • Potpara, T.S.1    Lip, G.Y.2    Apostolakis, S.3
  • 35
    • 84875780959 scopus 로고    scopus 로고
    • Dabigatran and postmarketing reports of bleeding
    • Southworth MR, Reichman ME, Unger EF,. Dabigatran and postmarketing reports of bleeding. N Engl J Med 2013; 368: 1272-1274.
    • (2013) N Engl J Med , vol.368 , pp. 1272-1274
    • Southworth, M.R.1    Reichman, M.E.2    Unger, E.F.3
  • 36
    • 84878292470 scopus 로고    scopus 로고
    • Efficacy and safety of dabigatran etexilate and warfarin in "real-world" patients with atrial fibrillation: A prospective nationwide cohort study
    • Larsen TB, Rasmussen LH, Skjøth F, et al. Efficacy and safety of dabigatran etexilate and warfarin in "real-world" patients with atrial fibrillation: A prospective nationwide cohort study. J Am Coll Cardiol 2013; 61: 2264-2273.
    • (2013) J Am Coll Cardiol , vol.61 , pp. 2264-2273
    • Larsen, T.B.1    Rasmussen, L.H.2    Skjøth, F.3
  • 37
    • 84878451205 scopus 로고    scopus 로고
    • Dabigatran use in Danish atrial fibrillation patients in 2011: A nationwide study
    • pii: e002758
    • Sørensen R, Gislason G, Torp-Pedersen C, et al. Dabigatran use in Danish atrial fibrillation patients in 2011: A nationwide study. BMJ Open 2013; 3. pii: e002758.
    • (2013) BMJ Open , vol.3
    • Sørensen, R.1    Gislason, G.2    Torp-Pedersen, C.3


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