Antibody Responses to Mycoplasma pneumoniae: Role in Pathogenesis and Diagnosis of Encephalitis?

PLoS Pathogens

Volumn 10, Issue 6, 2014, Pages

  Meyer Sauteur, Patrick M ^a,b   Jacobs, Bart C ^c   Spuesens, Emiel B M ^a   Jacobs, Enno ^d   Nadal, David ^b   Vink, Cornelis ^a,e   van Rossum, Annemarie M C ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CROSS REACTING ANTIBODY; GALACTOSYLCERAMIDE; GANGLIOSIDE; GANGLIOSIDE GM1; GANGLIOSIDE GQ 1B; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PROTEIN P30; BACTERIAL DNA; BACTERIUM ANTIBODY; BIOLOGICAL MARKER; C-GALACTOSYLCERAMIDE;

ANTIBODY RESPONSE; ARTICLE; BACTERIUM DETECTION; CEREBROSPINAL FLUID ANALYSIS; COMPLEMENT FIXATION TEST; CULTURE MEDIUM; DEMYELINATION; ENCEPHALITIS; ENZYME IMMUNOASSAY; GUILLAIN BARRE SYNDROME; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; MOLECULAR MIMICRY; MYCOPLASMA PNEUMONIA; MYCOPLASMA PNEUMONIAE; NERVE CELL; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CEREBROSPINAL FLUID; CROSS REACTION; GUILLAIN-BARRE SYNDROME; IMMUNOLOGY; ISOLATION AND PURIFICATION; MICROBIOLOGY; PATHOGENICITY; PATHOPHYSIOLOGY;

ANTIBODIES, BACTERIAL; BIOLOGICAL MARKERS; CROSS REACTIONS; DNA, BACTERIAL; ENCEPHALITIS; GALACTOSYLCERAMIDES; GANGLIOSIDES; GUILLAIN-BARRE SYNDROME; HUMANS; MODELS, IMMUNOLOGICAL; MOLECULAR MIMICRY; MYCOPLASMA PNEUMONIAE; PNEUMONIA, MYCOPLASMA;

EID: 84900486332     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003983     Document Type: Article

References (49)

1. Narita M, (2009) Pathogenesis of neurologic manifestations of Mycoplasma pneumoniae infection. Pediatr Neurol 41: 159-166.
2. Foy HM, (1993) Infections caused by Mycoplasma pneumoniae and possible carrier state in different populations of patients. Clin Infect Dis 17 (Suppl 1): S37-S46.
3. Lind K, Benzon MW, Jensen JS, Clyde WA Jr, (1997) A seroepidemiological study of Mycoplasma pneumoniae infections in Denmark over the 50-year period 1946-1995. Eur J Epidemiol 13: 581-586.
4. Michelow IC, Olsen K, Lozano J, Rollins NK, Duffy LB, et al. (2004) Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children. Pediatrics 113: 701-707.
5. Baer G, Engelcke G, Abele-Horn M, Schaad UB, Heininger U, (2003) Role of Chlamydia pneumoniae and Mycoplasma pneumoniae as causative agents of community-acquired pneumonia in hospitalised children and adolescents. Eur J Clin Microbiol Infect Dis 22: 742-745.
6. Principi N, Esposito S, Blasi F, Allegra L, (2001) Mowgli study group (2001) Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections. Clin Infect Dis 32: 1281-1289.
7. Juven T, Mertsola J, Waris M, Leinonen M, Meurman O, et al. (2000) Etiology of community-acquired pneumonia in 254 hospitalized children. Pediatr Infect Dis J 19: 293-298.
8. Narita M, (2010) Pathogenesis of extrapulmonary manifestations of Mycoplasma pneumoniae infection with special reference to pneumonia. J Infect Chemother 16: 162-169.
9. Christie LJ, Honarmand S, Talkington DF, Gavali SS, Preas C, et al. (2007) Pediatric encephalitis: what is the role of Mycoplasma pneumoniae? Pediatrics 120: 305-313.
10. Bitnun A, Ford-Jones EL, Petric M, MacGregor D, Heurter H, et al. (2001) Acute childhood encephalitis and Mycoplasma pneumoniae. Clin Infect Dis 32: 1674-1684.
11. Bitnun A, Ford-Jones E, Blaser S, Richardson S, (2003) Mycoplasma pneumoniae encephalitis. Semin Pediatr Infect Dis 14: 96-107.
12. Venkatesan A, Tunkel AR, Bloch KC, Lauring AS, Sejvar J, et al. (2013) Case Definitions, Diagnostic Algorithms, and Priorities in Encephalitis: Consensus Statement of the International Encephalitis Consortium. Clin Infect Dis 57: 1114-1128.
13. Spuesens EB, Fraaij PL, Visser EG, Hoogenboezem T, Hop WC, et al. (2013) Carriage of Mycoplasma pneumoniae in the upper respiratory tract of symptomatic and asymptomatic children: an observational study. PLoS Med 10: e1001444.
14. Wood PR, Hill VL, Burks ML, Peters JI, Singh H, et al. (2013) Mycoplasma pneumoniae in children with acute and refractory asthma. Ann Allergy Asthma Immunol 110: 328-334.e1.
15. Jacobs E, (1993) Serological diagnosis of Mycoplasma pneumoniae infections: a critical review of current procedures. Clin Infect Dis 17 (Suppl 1): S79-S82.
16. Waites KB, Talkington DF (2004) Mycoplasma pneumoniae and its role as a human pathogen. Clin Microbiol Rev 17: 697-728, table of contents.
17. Loens K, Goossens H, Ieven M, (2010) Acute respiratory infection due to Mycoplasma pneumoniae: current status of diagnostic methods. Eur J Clin Microbiol Infect Dis 29: 1055-1069.
18. Nadal D, Bossart W, Zucol F, Steiner F, Berger C, et al. (2001) Community-acquired pneumonia in children due to Mycoplasma pneumoniae: diagnostic performance of a seminested 16S rDNA-PCR. Diagn Microbiol Infect Dis 39: 15-19.
19. Beersma MF, Dirven K, van Dam AP, Templeton KE, Claas EC, et al. (2005) Evaluation of 12 commercial tests and the complement fixation test for Mycoplasma pneumoniae-specific immunoglobulin G (IgG) and IgM antibodies, with PCR used as the "gold standard". J Clin Microbiol 43: 2277-2285.
20. Ozaki T, Nishimura N, Ahn J, Watanabe N, Muto T, et al. (2007) Utility of a rapid diagnosis kit for Mycoplasma pneumoniae pneumonia in children, and the antimicrobial susceptibility of the isolates. J Infect Chemother 13: 204-207.
21. Gavranich JB, Chang AB, (2005) Antibiotics for community acquired lower respiratory tract infections (LRTI) secondary to Mycoplasma pneumoniae in children. Cochrane Database Syst Rev 2005: CD004875.
22. Reiber H, (1994) Flow rate of cerebrospinal fluid (CSF)- a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases. J Neurol Sci 122: 189-203.
23. Jacobs E, (2012) Mycoplasma pneumoniae: now in the focus of clinicians and epidemiologists. Euro Surveill 17: 1-3.
24. Dumke R, Strubel A, Cyncynatus C, Nuyttens H, Herrmann R, et al. (2012) Optimized serodiagnosis of Mycoplasma pneumoniae infections. Diagn Microbiol Infect Dis 73: 200-203.
25. Daxboeck F, Blacky A, Seidl R, Krause R, Assadian O, (2004) Diagnosis, treatment, and prognosis of Mycoplasma pneumoniae childhood encephalitis: systematic review of 58 cases. J Child Neurol 19: 865-871.
26. Domenech C, Leveque N, Lina B, Najioullah F, Floret D, (2009) Role of Mycoplasma pneumoniae in pediatric encephalitis. Eur J Clin Microbiol Infect Dis 28: 91-94.
27. Narita M, Yamada S, (2001) Two distinct patterns of central nervous system complications due to Mycoplasma pneumoniae infection. Clin Infect Dis 33: 916-917.
28. Bencina D, Dovc P, Mueller-Premru M, Avsic-Zupanc T, Socan M, et al. (2000) Intrathecal synthesis of specific antibodies in patients with invasion of the central nervous system by Mycoplasma pneumoniae. Eur J Clin Microbiol Infect Dis 19: 521-530.
29. Meyer Sauteur PM, Relly C, Hackenberg A, Stahr N, Berger C, et al. (2014) Mycoplasma pneumoniae Intrathecal Antibody Responses in Bickerstaff Brain Stem Encephalitis. Neuropediatrics 45: 61-63.
30. Christie LJ, Honarmand S, Yagi S, Ruiz S, Glaser CA, (2007) Anti-galactocerebroside testing in Mycoplasma pneumoniae-associated encephalitis. J Neuroimmunol 189: 129-131.
31. Jacobs E, Bartl A, Oberle K, Schiltz E, (1995) Molecular mimicry by Mycoplasma pneumoniae to evade the induction of adherence inhibiting antibodies. J Med Microbiol 43: 422-429.
32. Kusunoki S, Shiina M, Kanazawa I, (2001) Anti-Gal-C antibodies in GBS subsequent to mycoplasma infection: evidence of molecular mimicry. Neurology 57: 736-738.
33. Rottem S, (2003) Interaction of mycoplasmas with host cells. Physiol Rev 83: 417-432.
34. Willison HJ, Yuki N, (2002) Peripheral neuropathies and anti-glycolipid antibodies. Brain 125: 2591-2625.
35. Ang CW, Tio-Gillen AP, Groen J, Herbrink P, Jacobs BC, et al. (2002) Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome. J Neuroimmunol 130: 179-183.
36. Susuki K, Odaka M, Mori M, Hirata K, Yuki N, (2004) Acute motor axonal neuropathy after Mycoplasma infection: Evidence of molecular mimicry. Neurology 62: 949-956.
37. Arakawa H, Yuhara Y, Todokoro M, Kato M, Mochizuki H, et al. (2005) Immunoadsorption therapy for a child with Guillain-Barré syndrome subsequent to Mycoplasma infection: a case study. Brain Dev 27: 431-433.
38. Samukawa M, Hamada Y, Kuwahara M, Takada K, Hirano M, et al. (2013) Clinical features in Guillain-Barré syndrome with anti-Gal-C antibody. J Neurol Sci 337: 55-60.
39. van Doorn PA, Ruts L, Jacobs BC, (2008) Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome. Lancet Neurol 7: 939-950.
40. Saida T, Saida K, Dorfman SH, Silberberg DH, Sumner AJ, et al. (1979) Experimental allergic neuritis induced by sensitization with galactocerebroside. Science 204: 1103-1106.
41. Nishimura M, Saida T, Kuroki S, Kawabata T, Obayashi H, et al. (1996) Post-infectious encephalitis with anti-galactocerebroside antibody subsequent to Mycoplasma pneumoniae infection. J Neurol Sci 140: 91-95.
42. Kumada S, Kusaka H, Okaniwa M, Kobayashi O, Kusunoki S, (1997) Encephalomyelitis subsequent to mycoplasma infection with elevated serum anti-Gal C antibody. Pediatr Neurol 16: 241-244.
43. Sugeno N, Kawaguchi N, Hasegawa T, Kuroda T, Nakashima I, et al. (2012) A case with anti-galactocerebroside antibody-positive Mycoplasma pneumoniae meningoencephalitis presenting secondary hypersomnia. Neurol Sci 33: 1473-1476.
44. Kikuchi M, Tagawa Y, Iwamoto H, Hoshino H, Yuki N, (1997) Bickerstaff's brainstem encephalitis associated with IgG anti-GQ1b antibody subsequent to Mycoplasma pneumoniae infection: favorable response to immunoadsorption therapy. J Child Neurol 12: 403-405.
45. Steer AC, Starr M, Kornberg AJ, (2006) Bickerstaff brainstem encephalitis associated with Mycoplasma pneumoniae infection. J Child Neurol 21: 533-534.
46. Fusco C, Bonini E, Soncini G, Frattini D, Giovannini S, et al. (2010) Transient basal ganglia and thalamic involvement following Mycoplasma pneumoniae infection associated with antiganglioside antibodies. J Child Neurol 25: 1029-1033.
47. Odaka M, Yuki N, Yamada M, Koga M, Takemi T, et al. (2003) Bickerstaff's brainstem encephalitis: clinical features of 62 cases and a subgroup associated with Guillain-Barré syndrome. Brain 126: 2279-2290.
48. Monteyne P, Albert F, Weissbrich B, Zardini E, Ciardi M, et al. (1997) The detection of intrathecal synthesis of anti-herpes simplex IgG antibodies: comparison between an antigen-mediated immunoblotting technique and antibody index calculations. European Union Concerted Action on Virus Meningitis and Encephalitis. J Med Virol 53: 324-331.
49. Granerod J, Cunningham R, Zuckerman M, Mutton K, Davies NW, et al. (2010) Causality in acute encephalitis: defining aetiologies. Epidemiol Infect 138: 783-800.