Radical vaginal trachelectomy after laparoscopic staging and neoadjuvant chemotherapy in women with early-stage cervical cancer over 2 cm: Oncologic, fertility, and neonatal outcome in a series of 20 patients

International Journal of Gynecological Cancer

Volumn 24, Issue 3, 2014, Pages 586-593

  Lanowska, Malgorzata ^a   Mangler, Mandy ^a   Speiser, Dorothee ^a   Bockholdt, Caroline ^a   Schneider, Achim ^a   Köhler, Christhardt ^a   Vasiljeva, Jekaterina ^a   Al Hakeem, Malak ^a,b   Vercellino, Giuseppe F ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Cervical cancer; Fertility results; Fertility sparing treatment; Neoadjuvant chemotherapy; Radical vaginal trachelectomy

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; GONADORELIN AGONIST; IFOSFAMIDE; PACLITAXEL;

ADENOCARCINOMA; ADENOSQUAMOUS CARCINOMA; ADULT; ALOPECIA; ARTICLE; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER REGRESSION; CANCER SIZE; CANCER STAGING; CANCER SURGERY; CESAREAN SECTION; CHEMORADIOTHERAPY; CHILDBIRTH; CLINICAL ARTICLE; CONCEPTION; DRUG DOSE REDUCTION; DRUG INDUCED DISEASE; ECTOPIC PREGNANCY; ENDOMETRIOSIS; FEMALE; FEMALE FERTILITY; FERTILIZATION IN VITRO; FEVER; FOLLOW UP; GYNECOLOGIC SURGERY; HEMATOLOGIC DISEASE; HUMAN; ILIAC VEIN; INTRACYTOPLASMIC SPERM INJECTION; LAPAROSCOPIC SURGERY; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; LYMPHEDEMA; LYMPHOCELE; MALE; MENSTRUAL IRREGULARITY; MULTIPLE CYCLE TREATMENT; NEPHROTOXICITY; NEWBORN; OUTCOME ASSESSMENT; OVARY INSUFFICIENCY; PARENTHOOD; PELVIS LYMPHADENECTOMY; PEROPERATIVE COMPLICATION; POSTOPERATIVE COMPLICATION; PREGNANCY OUTCOME; PREGNANCY RATE; PREMATURE LABOR; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADICAL RESECTION; RADICAL VAGINAL TRACHELECTOMY; SPONTANEOUS ABORTION; STENOSIS; SURGICAL INFECTION; TREATMENT RESPONSE; URETER INJURY; URINARY TRACT INFECTION; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA; UTERINE CERVIX DILATATION; UTERINE CERVIX DISEASE; UTERINE CERVIX STENOSIS; VEIN INJURY; ADJUVANT THERAPY; CARCINOMA, SQUAMOUS CELL; CONSERVATIVE TREATMENT; FERTILITY; MINIMALLY INVASIVE SURGERY; PREGNANCY; TREATMENT OUTCOME; UTERINE CERVICAL NEOPLASMS;

ADENOCARCINOMA; ADULT; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; FEMALE; FERTILITY; FOLLOW-UP STUDIES; HUMANS; INFANT, NEWBORN; MALE; MINIMALLY INVASIVE SURGICAL PROCEDURES; NEOADJUVANT THERAPY; ORGAN SPARING TREATMENTS; PREGNANCY; PREGNANCY OUTCOME; TREATMENT OUTCOME; UTERINE CERVICAL NEOPLASMS;

EID: 84900458632     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0000000000000080     Document Type: Article

References (32)

1. Patel A, Galaal K, Burnley C, et al. Cervical cancer incidence in young women: a historical and geographic controlled UK regional population study. Br J Cancer. 2012;106:1753-1759.
2. Rob L, Skapa P, Robova H. Fertility-sparing surgery in patients with cervical cancer. Lancet Oncol. 2011;12:192-200.
3. Hertel H, Köhler C, Michels W, et al. Laparoscopic-assisted radical vaginal hysterectomy (LARVH): prospective evaluation of 200 patients with cervical cancer. Gynecol Oncol. 2003; 90:505-511.
4. Plante M, Renaud MC, Francois H, et al. Vaginal radical trachelectomy: an oncologically safe fertility-preserving surgery. An updated series of 72 patients and review of the literature. Gynecol Oncol. 2004;94:614-623.
5. Schlearth JB, Spirtos NM, Schlearth AC. Radical trachelectomy and pelvin lymphadenectomy with uterine preservation in the treatment of cervical cancer. Am J Obstet Gynecol. 2003; 188:29-34.
6. Shepherd JH, Spencer C, Herod J, et al. Radical vaginal trachelectomy as a fertility-sparing procedure in women with early-stage cervical cancer-cumulative pregnancy rate in a series of 123 women. BJOG. 2006;113:719-724.
7. Vercellino GF, Piek JM, Schneider A, et al. Laparoscopic lymph node dissection should be performed before fertility preserving treatment of patients with cervical cancer. Gynecol Oncol. 2012;126:325-329.
8. Kobayashi Y, Akiyama F, Hasumi K. A case of successful pregnancy after treatment of invasive cervical cancer with systemic chemotherapy and conization. Gynecol Oncol. 2006;100:213-215.
9. Maneo A, Chiari S, Bonazzi C, et al. Neoadjuvant chemotherapy and conservative surgery for stage IB1 cervical cancer. Gynecol Oncol. 2008;111:438-443.
10. Marchiole P, Tigaud JD, Costantini S, et al. Neoadjuvant chemotherapy and vaginal radical trachelectomy for fertility-sparing treatment in women affected by cervical cancer (FIGO stage IB-IIA1). Gynecol Oncol. 2011;122:484-490.
11. Plante M, Lau S, Brydon L, et al. Neoadjuvant chemotherapy followed by vaginal radical trachelectomy in bulky stage IB1 cervical cancer: a case report. Gynecol Oncol. 2006;101: 367-370.
12. Robova H, Halaska M, Pluta M, et al. The role of neoadjuvant chemotherapy and surgery in cervical cancer. Int J Gynecol Cancer. 2010;20:S42YS46.
13. Altgassen C, Hertel H, Brandstädt A, et al. Multicenter validation study of the sentinel lymph node concept in cervical cancer: AGO Study Group. J Clin Oncol. 2008;26:2943-2951.
14. Köhler C, Klemm PA, Possover M, et al. Introduction of transperitoneal lymphadenectomy in a gynecologic oncology center: analysis of 650 laparoscopic pelvic and/or paraaortic transperitoneal lymphadenectomies. Gynecol Oncol. 2004;95:52-61.
15. Lissoni AA, Colombo N, Pellegrino A, et al. A phase II, randomized trial of neo-adjuvant chemotherapy comparing a three-drug combination of paclitaxel, ifosfamide, and cisplatin (TIP) versus paclitaxel and cisplatin (TP) followed by radical surgery in patients with locally advanced squamous cell cervical carcinoma: the Snap-02 Italian Collaborative Study. Ann Oncol. 2009;20:660-665.
16. World Health Organization. WHO Handbook for Reporting Results for Cancer Treatment. Geneva, Switzerland: World Health Organization; 1979.
17. Marchiole P, Benchaib M, Buenerd A, et al. Oncological safety of laparoscopic-assisted vaginal radical trachelectomy (LARVT or Dargent's operation): a comparative study with laparoscopic-assisted vaginal radical hysterectomy (LARVH). Gycecol Oncol. 2007;106:132-141.
18. Li J, Wu X, Li X, et al. Abdominal radical trachelectomy: is it safe for IB1 cervical cancer with tumors Q2 cm? [published online ahead of print] Gynecol Oncol. 2013;131:87-92.
19. Linter B, Saso S, Tarnai L, et al. Use of abdominal radical vaginal trachelectomy to treat cervical cancer greater than 2 cm in diameter. Int J Gynecol Cancer. 2013;23:1065-1070.
20. Plante M. Evolution in fertility-preserving options for early-stage cervical cancer: radical trachelectomy, simple trachelectomy, neoadjuvant chemotherapy. Int J Gynecol Cancer. 2013;23:982-989.
21. Buda A, Fossati R, Colombo N, et al. Randomized trial of neoadjuvant chemotherapy comparing paclitaxel, ifosfamide, and cisplatin with ifosfamide and cisplatin followed by radical surgery in patients with locally advanced squamous cell cervical carcinoma: the SNAP01 (Studio Neo-Adjuvante Portio) Italian collaborative study. J Clin Oncol. 2005;23:4137-4145.
22. Lanowska M, Morawietz L, Sikora A, et al. Prevalence of lymph nodes in the parametrium of radical vaginal trachelectomy (RVT) specimen. Gynecol Oncol. 2011;121:298-302.
23. Winter R, Haas J, Reich O, et al. Parametrial spread of cervical cancer in patients with negative pelvic lymph nodes. Gynecol Oncol. 2002;84:252-257.
24. Bader AA, Winter R, Moinfar F, et al. Is intraoperative frozen section analysis of pelvic lymph nodes accurate after neoadjuvant chemotherapy in patients with cervical cancer? Gynecol Oncol. 2006;103:106-112.
25. Robova H, Halaska M, Pluta M, et al. The role of neoadjuvant chemotherapy and surgery in cervical cancer. Int J Gynecol Cancer. 2010;20:S42YS46.
26. Speiser D, Mangler M, Köhler C, et al. Fertility outcome after radical vaginal trachelectomy: a prospective study of 212 patients. Int J Gynecol Cancer. 2011;21:1635-1639.
27. Mangler M, Speiser D, Nguyen BD, et al. Neonatal outcome in infants of patients with radical vaginal trachelectomy. J Perinat Med. 2012;40:503-509.
28. Hamed AH, Shepard MK, Maglinte DD, et al. Neoadjuvant chemotherapy followed by simultaneous robitic radical trachelectomy and reversal of tubal sterilization in stag IB2 cervical cancer. JSLS. 2012;16:650-653.
29. Wang D, Yang J, Shen K, et al. Neoadjuvant chemotherapy followed by fertility-sparing surgery for women with stage IB1 cervical cancer. J Gynecol Oncol. 2013;24:287-290.
30. Palaia I, Musella A, Loperte E, et al. Neoadjuvant chemotherapy plus fertility-sparing surgery in locally advanced cervical cancer: case report. J Minim Invasive Gynecol. 2011;18: 121-122.
31. Liu H, Peng ZL, Lou JY, et al. Pregnancy after neoadjuvant chemotherapy followed by pelvic lymphadenectomy and radical trachelectomy in bulky stage IB1 cervical cancer: a case report. Aust N Z J Obstet Gynaecol. 2008;48:517-518.
32. Landoni F, Parma G, Peirettin M, et al. Chemo-conization in early cervical cancer.GynecolOncol. 2007;107(suppl):S125YS126.