NPM1 silencing reduces tumour growth and MAPK signalling in prostate cancer cells

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Loubeau, Gaeanddielle ^a,b,c,d   Boudra, Rafik ^a,b,c,d   Maquaire, Sabrina ^a,b,c,d   Lours Calet, Corinne ^a,b,c,d   Beaudoin, Claude ^a,b,c,d   Verrelle, Pierre ^a,e   Morel, Laurent ^a,b,c,d  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CNRS   (France)

^c Faculté de Médecine   (France)

^d CRNH AUVERGNE   (France)

^e CENTRE JEAN PERRIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NUCLEOPHOSMIN; NUCLEAR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL INVASION; CELL MIGRATION; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; MIGRATION INHIBITION; MOUSE; NONHUMAN; NUDE MOUSE; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; ANIMAL; CELL PROLIFERATION; GENETICS; MALE; METABOLISM; PHYSIOLOGY; PROSTATE TUMOR; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MICE, NUDE; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; PROSTATIC NEOPLASMS;

EID: 84900431943     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096293     Document Type: Article

References (26)

1. Leotoing L, Meunier L, Manin M, Mauduit C, Decaussin M, et al. (2008) Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell. Oncogene 27: 2858-2867. (Pubitemid 351620443)
2. Szebeni A, Herrera JE, Olson MO (1995) Interaction of nucleolar protein B23 with peptides related to nuclear localization signals. Biochemistry 34: 8037-8042.
3. Okuwaki M, Matsumoto K, Tsujimoto M, Nagata K (2001) Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone. FEBS Lett 506: 272-276. (Pubitemid 32964828)
4. Takemura M, Sato K, Nishio M, Akiyama T, Umekawa H, et al. (1999) Nucleolar protein B23.1 binds to retinoblastoma protein and synergistically stimulates DNA polymerase alpha activity. J Biochem 125: 904-909. (Pubitemid 29253559)
5. Okuda M, Horn HF, Tarapore P, Tokuyama Y, Smulian AG, et al. (2000) Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103: 127-140.
6. Lindstrom MS (2011) NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling. Biochem Res Int 2011: 195209.
7. Okuwaki M (2008) The structure and functions of NPM1/Nucleophsmin/B23, a multifunctional nucleolar acidic protein. J Biochem 143: 441-448.
8. Tanaka M, Sasaki H, Kino I, Sugimura T, Terada M (1992) Genes preferentially expressed in embryo stomach are predominantly expressed in gastric cancer. Cancer Res 52: 3372-3377.
9. Nozawa Y, Van Belzen N, Van der Made AC, Dinjens WN, Bosman FT (1996) Expression of nucleophosmin/B23 in normal and neoplastic colorectal mucosa. J Pathol 178: 48-52. (Pubitemid 26053395)
10. Sari A, Calli A, Altinboga AA, Pehlivan FS, Gorgel SN, et al. (2011) Nucleophosmin expression in renal cell carcinoma and oncocytoma. Apmis 120: 187-194.
11. Shields LB, Gercel-Taylor C, Yashar CM, Wan TC, Katsanis WA, et al. (1997) Induction of immune responses to ovarian tumor antigens by multiparity. J Soc Gynecol Investig 4: 298-304. (Pubitemid 27520159)
12. Di Fiore PP (2008) Playing both sides: nucleophosmin between tumor suppression and oncogenesis. J Cell Biol 182: 7-9.
13. Brady SN, Yu Y, Maggi LB Jr, Weber JD (2004) ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway. Mol Cell Biol 24: 9327-9338. (Pubitemid 39391671)
14. Li QF, Tang J, Liu QR, Shi SL, Chen XF (2010) Localization and altered expression of nucleophosmin in the nuclear matrix during the differentiation of human hepatocarcinoma SMMC-7721 cells induced by HMBA. Cancer Invest 28: 1004-1012.
15. Liu Y, Zhang F, Zhang XF, Qi LS, Yang L, et al. (2012) Expression of Nucleophosmin/NPM1 correlates with migration and invasiveness of colon cancer cells. J Biomed Sci 19: 53.
16. Davies P, Eaton CL (1989) Binding of epidermal growth factor by human normal, hypertrophic, and carcinomatous prostate. Prostate 14: 123-132. (Pubitemid 19154804)
17. Scher HI, Sarkis A, Reuter V, Cohen D, Netto G, et al. (1995) Changing pattern of expression of the epidermal growth factor receptor and transforming growth factor alpha in the progression of prostatic neoplasms. Clin Cancer Res 1: 545-550.
18. Tillotson JK, Rose DP (1991) Endogenous secretion of epidermal growth factor peptides stimulates growth of DU145 prostate cancer cells. Cancer Lett 60: 109-112.
19. Traish AM, Wotiz HH (1987) Prostatic epidermal growth factor receptors and their regulation by androgens. Endocrinology 121: 1461-1467. (Pubitemid 17155896)
20. Jones HE, Eaton CL, Barrow D, Dutkowski CM, Gee JM, et al. (1997) Comparative studies of the mitogenic effects of epidermal growth factor and transforming growth factor-alpha and the expression of various growth factors in neoplastic and non-neoplastic prostatic cell lines. Prostate 30: 219-231. (Pubitemid 27172833)
21. Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. Faseb J 22: 954-965. (Pubitemid 351519953)
22. Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T (2003) Regulation of matrix metalloproteinases: an overview. Mol Cell Biochem 253: 269-285.
23. Shandilya J, Swaminathan V, Gadad SS, Choudhari R, Kodaganur GS, et al. (2009) Acetylated NPM1 localizes in the nucleoplasm and regulates transcriptional activation of genes implicated in oral cancer manifestation. Mol Cell Biol 29: 5115-5127.
24. Inder KL, Lau C, Loo D, Chaudhary N, Goodall A, et al. (2009) Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction. J Biol Chem 284: 28410-28419.
25. Inder KL, Hill MM, Hancock JF (2010) Nucleophosmin and nucleolin regulate K-Ras signaling. Commun Integr Biol 3: 188-190.
26. Weber MJ, Gioeli D (2004) Ras signaling in prostate cancer progression. J Cell Biochem 91: 13-25.